An Update of Fungal Endophyte Diversity and Strategies for Augmenting Therapeutic Potential of their Potent Metabolites: Recent Advancement
Applied Biochemistry and Biotechnology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Abstract
Endophytic
fungi
represent
a
significant
renewable
resource
for
the
discovery
of
pharmaceutically
important
compounds,
offering
substantial
potential
new
drug
development.
Their
ability
to
address
growing
issue
resistance
has
drawn
attention
from
researchers
seeking
novel,
nature-derived
lead
molecules
that
can
be
produced
on
large
scale
meet
global
demand.
Recent
advancements
in
genomics,
metabolomics,
bioinformatics,
and
improved
cultivation
techniques
have
significantly
aided
identification
characterization
fungal
endophytes
their
metabolites.
Current
estimates
suggest
there
are
approximately
1.20
million
globally,
yet
only
around
16%
(190,000)
been
identified
studied
detail.
This
underscores
vast
untapped
pharmaceutical
research.
Research
increasingly
focused
transformation
bioactive
compounds
by
through
chemical
enzymatic
processes.
A
notable
example
is
anthraquinone
derivative
6-O-methylalaternin,
whose
cytotoxic
enhanced
addition
hydroxyl
group,
sharing
structural
similarities
with
its
parent
compound
macrosporin.
These
structure-bioactivity
studies
open
up
avenues
developing
safer
more
effective
therapeutic
agents
synthesizing
targeted
derivatives.
Despite
immense
promise,
challenges
remain,
particularly
large-scale
understanding
complexities
biosynthetic
pathways.
Additionally,
genetic
manipulation
optimized
metabolite
production
still
infancy.
Future
research
should
aim
overcome
these
limitations
focusing
efficient
methods
deeper
exploration
endophytes’
metabolic
capabilities
fully
harness
potential.
Graphical
Язык: Английский
Leveraging endophytic fungi and multiomics integration for targeted drug discovery
Elsevier eBooks,
Год журнала:
2025,
Номер
unknown, С. 277 - 293
Опубликована: Янв. 1, 2025
Язык: Английский
Enhanced phytoremediation of cadmium-contaminated soil using chelating agents and plant growth regulators: effect and mechanism
Royal Society Open Science,
Год журнала:
2024,
Номер
11(9)
Опубликована: Сен. 1, 2024
The
heavy
metal
cadmium
(Cd)
is
a
major
threat
to
food
safety
and
human
health.
Phytoremediation
the
most
widely
used
remediation
technology,
how
improve
efficiency
of
phytoremediation
has
become
key
issue.
In
this
study,
we
constructed
an
intensive
technology
for
Cd-contaminated
soil
with
biodegradable
chelating
agent
plant
growth
regulator
combined
maize
investigated
mechanism
technology.
results
showed
that
best
effect
was
achieved
in
treatment
10
−6
mol
l
−1
gibberellic
acid
(GA
3
)
6
mmol
kg
aspartate
diethoxysuccinic
(AES)
maize.
treatment,
total
biomass
extraction
were
3.6
8.67
times
higher
than
those
control,
respectively,
antioxidant
enzyme
activities
also
increased.
enriched
dominant
bacterial
genera
promote
metabolism
tolerance
stress,
which
turn
promoted
Cd
accumulation.
Structural
equation
modelling
indicated
large
concentration
activity
on
extraction.
enhanced
good
potential
safe
use
soil.
Язык: Английский