Abstract
An
important
aspect
of
the
treatment
chronic
cases
diabetes
is
enhancement
insulin
secretion
with
a
decrease
in
intestinal
glucose
absorption.
In
this
study,
prepared
alcoholic
Catharanthus
roseus
flower
extract‐fabricated
zinc
oxide
nanoparticles
(FZNPs)
were
characterized
by
UV–vis
spectrometer,
dynamic
light
scattering
(DLS),
X‐ray
diffraction
(XRD),
and
fourier
transform
infrared
spectroscopy
(FTIR)
instruments
antihyperglycemic
properties
tested
at
molecular
level
silico
method.
The
synthesis
FZNPs
possible,
characterization
report
showed
that
they
have
maximum
optical
361
nm,
small
grain
size
(15.68
nm),
negative
zeta
potential
(hydrophilic
nature).
hexagonal
structure
are
surrounded
several
functional
groups.
result
supports
related
structures,
as
well
Zn
(II)
diisophthalate
vindoline,
good
ADMET
properties.
Zn(II)
lead
interaction
alpha‐glucosidase
has
binding
affinity
‐6.3
kcal/mol,
whereas
vindoline
KATP
‐7.4
kcal/mol.
synthesized
ability
to
inhibit
targets
block
ion
channel
beta
cells.
reduce
absorption
promote
secretion,
so
can
effectively
manage
hyperglycaemic
condition
patients.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 16, 2025
Nanoparticles
have
great
potential
for
the
application
in
new
energy
and
aerospace
fields.
The
distribution
of
nanoparticle
sizes
is
a
critical
determinant
material
properties
serves
as
significant
parameter
defining
characteristics
zero-dimensional
nanomaterials.
In
this
study,
we
proposed
HRU2-Net†,
an
enhancement
U2-Net†
model,
featuring
multi-level
semantic
information
fusion.
This
approach
exhibits
strong
competitiveness
refined
segmentation
capabilities
segmentation.
It
achieves
Mean
intersection
over
union
(MIoU)
87.31%,
with
accuracy
rate
exceeding
97.31%,
leading
to
improvement
effectiveness
precision.
results
show
that
deep
learning-based
method
significantly
enhances
efficacy
nanomaterial
research,
which
holds
substantial
significance
advancement
science.
Journal of nano research,
Год журнала:
2025,
Номер
87, С. 75 - 94
Опубликована: Март 26, 2025
In
this
study,
zinc
oxide
(ZnO)
and
copper-doped
nanoparticles
(Cu-ZnO
NPs)
were
synthesized
using
a
green
method
that
employed
Rosmarinus
officinalis
leaf
extract
as
reducing
agent.
Copper
was
incorporated
dopant
at
concentrations
of
3%
5%.
Zinc
acetate
dihydrate
copper
served
the
precursors
dopants,
respectively.
The
samples
characterized
utilizing
range
techniques,
including
XRD,
SEM,
EDX,
Raman
spectroscopy,
UV-visible
PL
spectroscopy.
XRD
spectroscopy
analyses
validated
effective
incorporation
Cu²⁺
ions
into
ZnO
wurtzite
structure.
SEM
analysis
indicated
displayed
spherical
morphology,
while
EDX
confirmed
presence
(Zn),
(Cu),
oxygen
(O),
thereby
validating
sample's
purity.
spectra
revealed
reduction
in
optical
band
gap
with
increasing
Cu
concentration.
Photoluminescence
peaks
observed
383
nm
565
ascribed
to
electron
transitions
from
deep
donor
levels,
particularly
Zn
interstitials
vacancies.
5%
Cu-doped
NPs
demonstrated
highest
photocatalytic
activity,
achieving
90%
degradation
Rhodamine
B
(RhB)
dye
under
UV
irradiation
135
minutes.
They
also
exhibited
significant
antibacterial
against
Gram-positive
bacteria
(
Staphylococcus
aureus
)
compared
Gram-negative
Escherichia
coli
).
Pharmaceutics,
Год журнала:
2025,
Номер
17(4), С. 446 - 446
Опубликована: Март 31, 2025
Background/Objectives:
The
current
research
was
designed
to
quantify
the
active
phyto-constituents
and
investigate
in
vitro
biological
efficiency
of
different
garden
cress
(Lepidium
sativum
Linn.)
seed
extracts
against
chronic
diseases
as
well
vivo
toxicities
that
may
be
induced
mice
upon
administration
each
extract
at
both
studied
therapeutic
doses.
Methods:
L.
extracts,
such
methanolic,
aqueous,
acetone,
ethyl
acetate
assessed.
inhibition
percentage
(%)
median
inhibitory
concentration
(IC50)
values
were
estimated
acetylcholinesterase
enzyme,
diabetes
mellitus
(α-amylase
α-glucosidase
enzymes),
inflammation
(cyclooxygenase-1
(COX-1),
cyclooxygenase-2
(COX-2),
5-lipoxygenase
(5-LOX)
enzymes).
Additionally,
HepG-2,
Caco-2,
A549
cells
assessed
using
3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl
tetrazolium
bromide
(MTT)
assay.
Moreover,
might
hematological
(using
an
automatic
blood
analyzer)
biochemical
levels
evaluated.
Results:
It
found
methanolic
possessed
highest
activities
compared
other
extracts.
51.34,
54.35,
44.10,
43.48,
40.78%
acetylcholinesterase,
α-amylase,
α-glucosidase,
protein
denaturation,
proteinase
enzymes,
respectively.
also
exhibited
effect
COX-1
(55.05%),
COX-2
(57.30%),
5-LOX
(50.15%)
enzymes.
possesses
cytotoxic
activity
cells,
with
IC50
52.27,
40.73,
37.95
μg/mL,
lethal
doses
(LD50)
showed
safer
when
administered
orally,
followed
by
aqueous
then
extract.
acetone
no
alterations
orally
two
(1/10
1/20
LD50)
control.
Conclusions:
This
study
concluded
than
In
future,
efficacy
will
evaluated,
elucidation
its
mechanism
diseases.
Bioinorganic Chemistry and Applications,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
To
treat
urinary
tract
infections
(UTIs),
biosynthesized
silver
and
yttrium‐doped
nanoparticles
(AgNPs
Y‐AgNPs)
were
synthesized
from
pine
needle
leaf
extract
(PNLE).
The
crystalline
nature
of
the
NPs
was
demonstrated
by
X‐ray
diffraction.
Transmission
scanning
electron
microscopy
showed
that
AgNPs
Y‐AgNPs
are
dispersed
spherical,
with
average
particle
sizes
18.43
26.58
nm,
respectively.
chemical
composition
oxidation
states
revealed
photoelectron
spectroscopy,
while
elemental
compositions
explored
energy‐dispersive
analysis.
functional
groups
absorbance
peaks
Fourier
transform
infrared
spectroscopy
ultraviolet‐visible
possessed
luminescent
behavior
based
on
photoluminescence
studies
ferromagnetic
according
to
vibrating
sample
magnetometer
In
addition,
antibacterial
activity
against
six
uropathogenic
bacteria
assessed
performing
microdilution
assays
determine
minimum
inhibitory
concentration
(MIC)
bactericidal
(MBC)
which
ranged
between
0.0625
2
mg/mL,
agar
well
diffusion
assay
zones
inhibition
8–17
mm,
time‐kill
test
detecting
after
3
h,
antibiofilm
screening
at
concentrations
ranging
1
mg/mL.
antioxidant
determined
1,1,
diphenyl
1‐2
picrylhydrazyl
(DPPH)
radical
scavenging
assay,
a
significant
(14.2%–55.6%).
Docking
can
inhibit
vital
enzymes
DNA
gyrase,
penicillin‐binding
proteins,
carbapenemase,
LasR‐binding
protein,
dihydropteroate
synthase.
These
results
highlight
use
as
alternative
approaches
in
battle
antibiotic‐resistant
UTIs.
research
illustrates
increased
bioactivity
compared
conventional
AgNPs.
It
paves
way
for
novel
nanomaterials
antimicrobial
medicine.
