Nano‐informatics Approach to Unravel the Intrinsic Interaction of Catharanthus roseus Fabricated Zinc Oxide Nanoparticles with Vindoline to Combat Diabetes DOI
Richa Goyal, Manoj Kumar,

M. Anwar Mallick

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(48)

Published: Dec. 1, 2024

Abstract An important aspect of the treatment chronic cases diabetes is enhancement insulin secretion with a decrease in intestinal glucose absorption. In this study, prepared alcoholic Catharanthus roseus flower extract‐fabricated zinc oxide nanoparticles (FZNPs) were characterized by UV–vis spectrometer, dynamic light scattering (DLS), X‐ray diffraction (XRD), and fourier transform infrared spectroscopy (FTIR) instruments antihyperglycemic properties tested at molecular level silico method. The synthesis FZNPs possible, characterization report showed that they have maximum optical 361 nm, small grain size (15.68 nm), negative zeta potential (hydrophilic nature). hexagonal structure are surrounded several functional groups. result supports related structures, as well Zn (II) diisophthalate vindoline, good ADMET properties. Zn(II) lead interaction alpha‐glucosidase has binding affinity ‐6.3 kcal/mol, whereas vindoline KATP ‐7.4 kcal/mol. synthesized ability to inhibit targets block ion channel beta cells. reduce absorption promote secretion, so can effectively manage hyperglycaemic condition patients.

Language: Английский

Biosynthesis and activity of Zn-MnO nanocomposite in vitro with molecular docking studies against multidrug resistance bacteria and inflammatory activators DOI Creative Commons
Samy Selim, Tarek M. Abdelghany, Mohammed S. Almuhayawi

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 15, 2025

Language: Английский

Citations

1
Multifunctional assessment of copper-doped ZnO nanoparticles synthesized via gliding arc discharge plasma technique: antioxidant, antibacterial, and photocatalytic performance DOI

Latra Benkhira,

Mohammed Fouad Ferhat,

Mohammed Tayeb Oucif Khaled

et al.

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(31), P. 43743 - 43756

Published: June 22, 2024

Language: Английский

Citations

7
The segmentation of nanoparticles with a novel approach of HRU2-Net† DOI Creative Commons
Yu Zhang, Heng Zhang, Fengfeng Liang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 16, 2025

Nanoparticles have great potential for the application in new energy and aerospace fields. The distribution of nanoparticle sizes is a critical determinant material properties serves as significant parameter defining characteristics zero-dimensional nanomaterials. In this study, we proposed HRU2-Net†, an enhancement U2-Net† model, featuring multi-level semantic information fusion. This approach exhibits strong competitiveness refined segmentation capabilities segmentation. It achieves Mean intersection over union (MIoU) 87.31%, with accuracy rate exceeding 97.31%, leading to improvement effectiveness precision. results show that deep learning-based method significantly enhances efficacy nanomaterial research, which holds substantial significance advancement science.

Language: Английский

Citations

0
One pot synthesis of SeTe–ZnO nanoparticles for antibacterial and wound healing applications DOI Creative Commons
Yushu Wang, Shahin Shah Khan,

I. Ullah

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(5), P. 3439 - 3447

Published: Jan. 1, 2025

SeTe–ZnO NP with dual photodynamic and photothermal properties were synthesized for antibacterial wound healing.

Language: Английский

Citations

0
Ecofriendly Biosynthesis of Zinc Oxide Nanoparticles (ZnO NPs) from Arthrospira platensis and Their Assessment for Antimicrobial, Antibiofilm, Anticancer Potency and Alleviation of Copper Stress in Vicia faba (L.) Plant DOI Creative Commons
Walaa A. Abo-Shanab, Sobhy E. Elsilk,

Salsabil S. Afifi

et al.

Journal of soil science and plant nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Language: Английский

Citations

0
Exploring Mn4+ dopant concentration to differentiate selective antimicrobial activity of Mn4+/MgO nanocomposites: Insights into binding affinity DOI

R. Sreekanth,

Jayadev Pattar, Vaddi Damodara Reddy

et al.

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114336 - 114336

Published: March 1, 2025

Language: Английский

Citations

0
Evaluation of the Photocatalytic and Antimicrobial Properties of Cu-Doped ZnO Nanoparticles Synthesized by Phytochemical Methods DOI

Khaled Chettah,

S. Boudjadar,

Badreddine Toubal

et al.

Journal of nano research, Journal Year: 2025, Volume and Issue: 87, P. 75 - 94

Published: March 26, 2025

In this study, zinc oxide (ZnO) and copper-doped nanoparticles (Cu-ZnO NPs) were synthesized using a green method that employed Rosmarinus officinalis leaf extract as reducing agent. Copper was incorporated dopant at concentrations of 3% 5%. Zinc acetate dihydrate copper served the precursors dopants, respectively. The samples characterized utilizing range techniques, including XRD, SEM, EDX, Raman spectroscopy, UV-visible PL spectroscopy. XRD spectroscopy analyses validated effective incorporation Cu²⁺ ions into ZnO wurtzite structure. SEM analysis indicated displayed spherical morphology, while EDX confirmed presence (Zn), (Cu), oxygen (O), thereby validating sample's purity. spectra revealed reduction in optical band gap with increasing Cu concentration. Photoluminescence peaks observed 383 nm 565 ascribed to electron transitions from deep donor levels, particularly Zn interstitials vacancies. 5% Cu-doped NPs demonstrated highest photocatalytic activity, achieving 90% degradation Rhodamine B (RhB) dye under UV irradiation 135 minutes. They also exhibited significant antibacterial against Gram-positive bacteria ( Staphylococcus aureus ) compared Gram-negative Escherichia coli ).

Language: Английский

Citations

0
Investigations of In Vitro Anti-Acetylcholinesterase, Anti-Diabetic, Anti-Inflammatory, and Anti-Cancer Efficacy of Garden Cress (Lepidium sativum Linn.) Seed Extracts, as Well as In Vivo Biochemical and Hematological Assays DOI Creative Commons
Ahmed M. Naglah, Abdulrahman A. Almehizia, Mohamed A. Al‐Omar

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 446 - 446

Published: March 31, 2025

Background/Objectives: The current research was designed to quantify the active phyto-constituents and investigate in vitro biological efficiency of different garden cress (Lepidium sativum Linn.) seed extracts against chronic diseases as well vivo toxicities that may be induced mice upon administration each extract at both studied therapeutic doses. Methods: L. extracts, such methanolic, aqueous, acetone, ethyl acetate assessed. inhibition percentage (%) median inhibitory concentration (IC50) values were estimated acetylcholinesterase enzyme, diabetes mellitus (α-amylase α-glucosidase enzymes), inflammation (cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX) enzymes). Additionally, HepG-2, Caco-2, A549 cells assessed using 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Moreover, might hematological (using an automatic blood analyzer) biochemical levels evaluated. Results: It found methanolic possessed highest activities compared other extracts. 51.34, 54.35, 44.10, 43.48, 40.78% acetylcholinesterase, α-amylase, α-glucosidase, protein denaturation, proteinase enzymes, respectively. also exhibited effect COX-1 (55.05%), COX-2 (57.30%), 5-LOX (50.15%) enzymes. possesses cytotoxic activity cells, with IC50 52.27, 40.73, 37.95 μg/mL, lethal doses (LD50) showed safer when administered orally, followed by aqueous then extract. acetone no alterations orally two (1/10 1/20 LD50) control. Conclusions: This study concluded than In future, efficacy will evaluated, elucidation its mechanism diseases.

Language: Английский

Citations

0
One-step electrochemical synthesis of CuxO–ZnO for antifungal activity DOI

Hà Xuân Linh,

Nguyễn Quốc Dũng, Hoai Linh Pham

et al.

Applied Nanoscience, Journal Year: 2025, Volume and Issue: 15(3)

Published: April 19, 2025

Language: Английский

Citations

0
Silver and Yttrium‐Doped Silver Nanoparticles From Pine Needle Leaf Extract: Synthesis, Characterization, Antioxidant, Antiuropathogenic Bacterial, and Docking Activities DOI Creative Commons
Nourhane A. Darwich, Malak Mezher, A. M. Abdallah

et al.

Bioinorganic Chemistry and Applications, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

To treat urinary tract infections (UTIs), biosynthesized silver and yttrium‐doped nanoparticles (AgNPs Y‐AgNPs) were synthesized from pine needle leaf extract (PNLE). The crystalline nature of the NPs was demonstrated by X‐ray diffraction. Transmission scanning electron microscopy showed that AgNPs Y‐AgNPs are dispersed spherical, with average particle sizes 18.43 26.58 nm, respectively. chemical composition oxidation states revealed photoelectron spectroscopy, while elemental compositions explored energy‐dispersive analysis. functional groups absorbance peaks Fourier transform infrared spectroscopy ultraviolet‐visible possessed luminescent behavior based on photoluminescence studies ferromagnetic according to vibrating sample magnetometer In addition, antibacterial activity against six uropathogenic bacteria assessed performing microdilution assays determine minimum inhibitory concentration (MIC) bactericidal (MBC) which ranged between 0.0625 2 mg/mL, agar well diffusion assay zones inhibition 8–17 mm, time‐kill test detecting after 3 h, antibiofilm screening at concentrations ranging 1 mg/mL. antioxidant determined 1,1, diphenyl 1‐2 picrylhydrazyl (DPPH) radical scavenging assay, a significant (14.2%–55.6%). Docking can inhibit vital enzymes DNA gyrase, penicillin‐binding proteins, carbapenemase, LasR‐binding protein, dihydropteroate synthase. These results highlight use as alternative approaches in battle antibiotic‐resistant UTIs. research illustrates increased bioactivity compared conventional AgNPs. It paves way for novel nanomaterials antimicrobial medicine.

Language: Английский

Citations

0