Future Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 10(1)
Опубликована: Ноя. 17, 2024
Язык: Английский
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 180, С. 117404 - 117404
Опубликована: Сен. 21, 2024
Язык: Английский
Процитировано
13
Pharmaceutics, Год журнала: 2024, Номер 17(1), С. 36 - 36
Опубликована: Дек. 30, 2024
Liposome-based drug delivery technologies have showed potential in enhancing medication safety and efficacy. Innovative loading release mechanisms highlighted this review of next-generation liposomal formulations. Due to poor kinetics capacity, conventional liposomes limited clinical use. Scientists developed new carrier control encapsulation methods address these limits. Drug can be optimized by creating lipid compositions that match a drug's charge hydrophobicity. By selecting lipids adding co-solvents or surfactants, scientists increased formulations while maintaining stability. Nanotechnology has also created multifunctional with triggered personalized delivery. Surface modification like PEGylation ligand conjugation direct disease regions, improving therapeutic efficacy reducing off-target effects. In addition loading, researchers focused on spatiotemporal modulation release. Stimuli-responsive drugs response bodily signals. Liposomes pH- temperature-sensitive. To improve reduce systemic toxicity, added stimuli-responsive components membranes precisely kinetics. Advanced magnetic targeting ultrasound. Pro Drug, RNA approach may administration. Magnetic helps aggregate at illness sites improves delivery, whereas ultrasound-mediated facilitates on-demand encapsulated medicines. This covers recent preclinical research showing the promise for cancer, infectious diseases, neurological disorders inflammatory disorders. The transfer innovative from lab practice involves key difficulties such scalability, manufacturing difficulty, regulatory
Язык: Английский
Процитировано
8
The Microbe, Год журнала: 2025, Номер unknown, С. 100242 - 100242
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Crystals, Год журнала: 2025, Номер 15(4), С. 296 - 296
Опубликована: Март 25, 2025
Cooling crystallization experiments of curcumin in isopropanol confirmed that can crystallize via classical or nonclassical pathways, depending on the levels supersaturation and supercooling. Light microscopy analysis revealed produces needle-shaped single crystals with an equilibrium habit, while results spherulitic mesocrystals. Through a series under various conditions, we developed crystal habit phase diagram for pure isopropanol. Presented here first time, this illustrates relationship between supersaturation, supercooling, offering valuable guide controlling pathways.
Язык: Английский
Процитировано
0
Nano-Structures & Nano-Objects, Год журнала: 2024, Номер 40, С. 101352 - 101352
Опубликована: Сен. 26, 2024
Язык: Английский
Процитировано
3
ACS Applied Bio Materials, Год журнала: 2024, Номер unknown
Опубликована: Дек. 16, 2024
A zwitterionic, stimuli-responsive liposomal system was meticulously designed for the precise and controlled delivery of curcumin, leveraging enzyme-specific hyperthermic stimuli to enhance therapeutic outcomes. This platform is specifically engineered release curcumin in response phospholipase A2, an enzyme that degrades phospholipids, enabling highly targeted site-specific drug release. Mild hyperthermia (40 °C) further enhances membrane permeability activates thermosensitive carriers, optimizing delivery. Curcumin encapsulation facilitated through a combination zwitterionic electrostatic interactions, significantly improving both loading capacity efficiency. design experiments (DoE) approach employed systematically optimize lipid-to-cholesterol ratios formulation conditions. The thoroughly characterized using dynamic light scattering, zeta potential measurements, transmission electron microscopy, ensuring stability structural integrity. Notably, this effectively encapsulates hydrophobic while maintaining particle size bioactivity. In vitro studies revealed robust antioxidant anti-ROS activities, alongside excellent biocompatibility, with no cytotoxicity observed at concentrations up 2000 μg/mL. Furthermore, liposomes enhanced M2 macrophage polarization reduced oxidative stress. advanced offers promising, biocompatible solution
Язык: Английский
Процитировано
2
Technology in Cancer Research & Treatment, Год журнала: 2024, Номер 23
Опубликована: Янв. 1, 2024
The type of algorithm employed to predict drug release from liposomes plays an important role in affecting the accuracy. In recent years, Machine Learning (ML) has shown potential for modeling complex delivery systems and predicting dynamics with a greater degree precision. this regard, Random Forest (RF) Support Vector (SVM) are two ML algorithms that have been extensively applied various biomedical contexts. Yet, direct comparisons their predictive accuracy ultrasound-triggered remain limited. Existing studies predominantly focus on under static conditions or limited external stimuli rather than dynamic, nonlinear responses observed ultrasound exposure. Objective This study presents comparative analysis RF SVM calcein ultrasound-triggered, targeted varied low-frequency (LFUS) power densities (6.2, 9, 10 mW/cm 2 ). Methods Liposomes loaded seven different moieties (cRGD, estrone, folate, Herceptin, hyaluronic acid, lactobionic transferrin) were synthesized using thin-film hydration method. characterized Dynamic Light Scattering Bicinchoninic Acid assays. Extensive data collection preprocessing performed. models trained evaluated mean absolute error (MAE), squared (MSE), coefficient determination (R²), a20 index as performance metrics. Results consistently outperformed SVM, achieving R scores above 0.96 across all densities, particularly excelling at higher indicating strong correlation actual data. Conclusion outperforms prediction, though both show strengths apply based specific prediction needs.
Язык: Английский
Процитировано
2
ACS Applied Nano Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 10, 2024
Язык: Английский
Процитировано
0
Future Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 10(1)
Опубликована: Ноя. 17, 2024
Язык: Английский
Процитировано
0