Association of body roundness index with diabetes and prediabetes in US adults from NHANES 2007–2018: a cross-sectional study

Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)

Опубликована: Авг. 17, 2024

The present study examined the ability of body roundness index (BRI) to predict incidence diabetes and prediabetes among adults in USA.

Язык: Английский

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Perspective from NHANES data: synergistic effects of visceral adiposity index and lipid accumulation products on diabetes risk

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 2, 2025

Язык: Английский

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Association between Chinese visceral adiposity index and lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH): a national cohort study

BMC Urology, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 23, 2025

Benign prostatic hyperplasia (BPH) and its related lower urinary tract symptoms (LUTS) are commonly observed among aging males have a substantial effect on quality of life. Metabolic syndrome, with specific focus obesity, is believed to play role in the development BPH. This study intends explore relationship between several obesity-related metrics, including Chinese Visceral Adiposity Index (CVAI), LUTS/BPH within national cohort men. Data from China Health Retirement Longitudinal Study (CHARLS) 2015 were analyzed, encompassing sample 5,735 male participants aged 45 older. Eight indices—namely Body mass index (BMI), Waist-height ratio (WHtR), Triglyceride-glucose.BMI (TyG.BMI), TyG. Waist circumference (TyG.WC), TyG.WHtR, CVAI, adiposity (VAI), A body shape (ABSI)—were examined. Logistic regression models, adjusted for potential confounders, utilized evaluate associations these indices LUTS or The predictive capabilities further assessed using receiver operating curves (ROC). Among participants, 718 (12.5%) diagnosed LUTS/BPH. All significantly higher group compared healthy group. CVAI demonstrated highest ability LUTS/BPH, an area under curve (AUC) 0.58. highlighted nonlinear indices, CVAI. underscores significant association visceral fat, as measured by risk emerged most effective predictor evaluated, suggesting utility identifying individuals at Further prospective studies needed confirm findings elucidate underlying mechanisms.

Язык: Английский

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Correlation between liver fibrosis in non-alcoholic fatty liver disease and insulin resistance indicators: a cross-sectional study from NHANES 2017–2020

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Янв. 31, 2025

Introduction Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic worldwide, with fibrosis (LF) being crucial pathological feature in the progression NAFLD. Insulin resistance (IR) believed to play an important role pathogenesis NAFLD and development LF. This study aims explore relationship between various IR indicators LF patients Methods utilized data from National Health Nutrition Examination Survey 2017-2020 cycles. Liver steatosis were assessed using ultrasound transient elastography. To assess association multiple LF, methodology included univariate multivariate logistic regression, as well restricted cubic spline (RCS) analysis. Subsequently, we used regression develop validate predictive model for evaluated model’s performance area under curve (AUC) calibration curve. Results A total 904 final Among these patients, 153 (16.92%) had Compared non-LF significantly higher body mass index (BMI), waist circumference (WC), alanine aminotransferase (ALT), aspartate (AST), gamma-glutamyl transferase (GGT), HbA1c, fasting blood glucose (FBG) levels (all p < 0.05). Analysis showed that TyG, TyG-WHtR, TyG-BMI, TyG-WC, TyG-GGT, METS-IR, HOMA-IR After adjusting covariates, TyG-WHtR remained independent risk factor (OR=2.69; 95% CI: 2.08-3.47), indicating strong correlation The developed nomogram, incorporating AST, diabetes, AUC 0.809 (95% 0.771-0.847), good patients. Conclusions confirms significant nomogram provides practical tool early assessment. These findings underscore clinical value indices into routine practice identify high-risk enabling timely interventions prevent improve outcomes.

Язык: Английский

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Sex differences in associations of metabolic inflammation and insulin resistance with incident type 2 diabetes mellitus: a retrospective cohort of adults with annual health examinations

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 14, 2025

Cardio-kidney-metabolic diseases are major causes of premature death worldwide, with type 2 diabetes mellitus (T2DM) playing a critical role. Inflammation and insulin resistance have been implicated in the pathogenesis T2DM. This study aimed to investigate sex-specific associations metabolic inflammation incident T2DM support personalized prevention management strategies. A retrospective cohort was used analyse annual health examination data from general practice department hospital Shanghai between 2021 2023. After excluding participants diagnosed T2DM, cardiovascular disease or chronic kidney at baseline, 1214 adults were followed up for two years. Cox proportional hazards logistic regression models assess triglyceride–glucose body mass index (TyG-BMI), lymphocyte/high-density lipoprotein cholesterol ratio (LHR), monocyte/high-density (MHR), neutrophil/high-density (NHR) In total population, TyG-BMI (all HR/OR > 1, P < 0.05), LHR, MHR NHR significantly positively associated men (both whereas strongly women 0.05). The interaction effect LHR sex statistically significant. Sex differences play an important role Men should be aware weight control avoid obesity-related resistance, monitor indicators such as early detection intervention their risk.

Язык: Английский

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Comparison of obesity indicators for predicting cardiovascular risk factors and multimorbidity among the Chinese population based on ROC analysis

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Сен. 9, 2024

Язык: Английский

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Association of Chinese visceral adiposity index with asymptomatic hyperuricemia incidence in type 2 diabetes: a cross-sectional study

PeerJ, Год журнала: 2025, Номер 13, С. e19045 - e19045

Опубликована: Фев. 26, 2025

Background Previous research has shown a correlation between high visceral fat levels and hyperuricemia incidence. The Chinese Visceral Adiposity Index (CVAI) assessed status in the population. Our study investigates CVAI asymptomatic type 2 diabetes patients. Methods This cross-sectional analyzed 1,588 hospitalized patients to investigate association hyperuricemia. was included logistic regression analysis as both continuous categorical variable, restricted cubic splines were used assess dose-response relationship. Additionally, subgroup analyses performed potential interactions among variables. predictive capability of using receiver operating characteristic (ROC) curve based on basic model. Results quartile group revealed higher prevalence with increasing levels. is significantly associated hyperuricemia, identified through multifactorial analysis. After adjusting for all covariates, odds ratios second, third, fourth quartiles than lowest quartile, values 2.688 (95% CI [1.301–5.554], p = 0.008), 2.752 [1.320–5.739], 0.007), 4.990 [2.392–10.409], < 0.001), respectively. No significant observed Incorporating into model increased ROC curve’s area under 0.714. Conclusion found positive incidence Consequently, may reliably indicate this patient

Язык: Английский

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Association between the triglyceride glucose-Chinese visceral adiposity index and new-onset stroke risk: a national cohort study

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Март 12, 2025

Numerous studies have investigated the effect of an integrated index that combines triglyceride‒glucose (TyG) with various obesity indicators on stroke incidence. However, how to use TyG and Chinese Visceral Adiposity Index (CVAI) for prevention remains unclear. This study examined associations between dynamic changes in TyG-CVAI cumulative, baseline, new-onset risk. Data from 3,769 participants China Health Retirement Longitudinal Study(CHARLS) were analyzed, concentrating baseline TyG-CVAI, 2015, cumulative derived these. The fluctuations grouped into three clusters using K-means clustering analysis. Logistic regression models used examine relationship Restricted cubic splines (RCS) employed investigate potential nonlinear relationships while assessing predictive capability by receiver operating characteristic curve. During follow-up period, 181 experienced events. incidence rates Clusters 1, 2, 3 2.42%, 8.72%, 4.37%, respectively. After adjustment confounding factors, Cluster 2 high increasing (OR = 3.16, 95% CI 1.94–5.22), Q3 group 2.53, 1.60–4.02), 2.49, 1.57–3.95),which all correlated elevated risk stroke. RCS analysis disclosed a U-shaped TyG–CVAI are independently increased is anticipated be more efficient significant indicator evaluating early

Язык: Английский

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Research Progress on the Relationship between Visceral Obesity and Related Indices and Type 2 Diabetes Mellitus

Journal of Clinical Personalized Medicine, Год журнала: 2025, Номер 04(02), С. 175 - 185

Опубликована: Янв. 1, 2025

Язык: Английский

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Associations of obesity and novel lipid indicators in the risk of type 2 diabetes mellitus in Chinese elderly hypertensive patients

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Апрель 1, 2025

Background The associations of waist circumference (WC), body mass index (BMI), lipid accumulation product (LAP), Chinese visceral adiposity (CVAI), and triglyceride-glucose Index (TyG) with the risk type 2 diabetes mellitus (T2DM) remained uncertain in middle-aged elderly hypertensive patients. Methods A total 1,965 participants aged 45 years were included cross-sectional analysis, 1,576 without T2DM for cohort analysis. In study, binary logistic regression, restricted cubic splines (RCS), receiver operating characteristic (ROC) used to analyze relationships between WC, BMI, LAP, CVAI, TyG Kaplan-Meier survival analyses Cox regression further performed determine these indicators incident risk. Results there 101 cases occurred during a median follow-up 30 months, an rate was 2.78 per 100 person-years. study showed that increased significantly higher quartiles (all P -trend &lt; 0.001). model WC (Q4 vs. Q1, HR = 3.30, 95% CI 1.66-6.59), BMI 2.38, 1.30-4.36), LAP 5.15, 2.40-11.02), CVAI 3.38, 1.76-6.50), 5.76, 2.82-11.77) associated T2DM. RCS confirmed positive dose-response both design, except study. Additionally, ROC analysis revealed had strongest area under curve (AUC) 0.70 (95% 0.67-0.72) AUC other ranged from 0.55 0.57. Conclusion Higher levels are riskof developing patients, might be most effective predictive indicator.

Язык: Английский

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