Aging Cell, Год журнала: 2021, Номер 20(9)
Опубликована: Авг. 20, 2021
Abstract Advanced age is the main common risk factor for cancer, cardiovascular disease and neurodegeneration. Yet, more known about molecular basis of any these groups diseases than changes that accompany ageing itself. Progress in research was slow because tools predicting whether someone aged slowly or fast (biological age) were unreliable. To understand as a to develop interventions, field needed quantitative measure; clock biological age. Over past decade, number predictors utilising DNA methylation have been developed, referred epigenetic clocks. While they appear estimate age, it remains unclear used train clocks are reflection other underlying cellular processes, itself involved process. The precise aspects capture remain hidden seem vary between predictors. Nonetheless, use has opened door towards studying quantitatively, new applications, such forensics, frequently. In this review, we will discuss range available, their strengths weaknesses, applicability various scientific queries.
Язык: Английский