bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Май 13, 2023
The
socially
monogamous
prairie
vole
(
Microtus
ochrogaster
)
and
promiscuous
meadow
pennsylvanicus
are
closely
related,
but
only
voles
display
long-lasting
pair
bonds,
biparental
care,
selective
aggression
towards
unfamiliar
individuals
after
bonding.
These
social
behaviors
in
mammals
largely
mediated
by
steroid
hormone
signaling
the
behavior
network
(SBN)
of
brain.
Hormone
receptors
reproducible
markers
sex
differences
that
can
provide
more
information
than
anatomy
alone,
even
be
at
odds
with
anatomical
dimorphisms.
We
reasoned
associated
monogamy
may
emerge
part
from
unique
expression
patterns
this
species,
these
would
similar
across
males
females
or
laboratory
mouse.
To
obtain
insight
into
developing
brain,
we
assessed
estrogen
receptor
alpha
Esr1
),
beta
Esr2
androgen
Ar
within
SBN,
using
situ
hybridization
postnatal
day
14
mice,
meadow,
voles.
found
species-specific
hippocampus
ventromedial
hypothalamus,
as
well
species
bias
principal
nucleus
bed
stria
terminalis.
findings
suggest
observed
gonadal
underlie
behaviors.
iScience,
Год журнала:
2025,
Номер
28(2), С. 111820 - 111820
Опубликована: Янв. 18, 2025
The
lateral
septum
(LS)
is
a
midline,
subcortical
structure
that
critical
regulator
of
social
behaviors.
Mouse
studies
have
identified
molecularly
distinct
neuronal
populations
within
the
LS,
which
control
specific
facets
behavior.
Despite
its
known
molecular
heterogeneity
in
mouse
and
role
regulating
behavior,
comprehensive
profiling
human
LS
has
not
been
performed.
Here,
we
conducted
single-nucleus
RNA
sequencing
(snRNA-seq)
to
generate
transcriptomic
profiles
compared
recently
collected
snRNA-seq
datasets.
Our
analyses
TRPC4
as
conserved
marker
while
FREM2
enriched
only
LS.
We
also
identify
cell
type
marked
by
OPRM1,
gene
encoding
μ-opioid
receptor.
Together,
these
results
highlight
transcriptional
robust
genes
for
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 11, 2025
Behavioral
flexibility
allows
animals
to
adjust
actions
changing
environments.
While
the
basal
ganglia
are
critical
for
adaptation,
specific
role
of
external
globus
pallidus
(GPe)
is
unclear.
This
study
examined
contributions
two
major
GPe
cell
types-prototypic
neurons
projecting
subthalamic
nucleus
(Proto
GPe→STN
neurons)
and
astrocytes-to
behavioral
flexibility.
Using
longitudinal
operant
conditioning
with
context
reversals,
we
found
that
Proto
dynamically
represent
contextual
information
correlating
optimality.
In
contrast,
astrocytes
exhibited
gradual
encoding
independent
performance.
Deleting
impaired
adaptive
responses
action-outcome
contingencies
without
altering
initial
reward-seeking
acquisition,
highlighting
their
in
enabling
Furthermore,
discovered
integrate
inhibitory
striatal
excitatory
inputs,
modulating
downstream
circuits
support
flexible
behavior.
research
elucidates
complementary
roles
cellular
mechanisms
Neuroscience & Biobehavioral Reviews,
Год журнала:
2024,
Номер
161, С. 105683 - 105683
Опубликована: Апрель 21, 2024
The
lateral
septum
(LS)
is
involved
in
controlling
anxiety,
aggression,
feeding,
and
other
motivated
behaviors.
Lesion
studies
have
also
implicated
the
LS
various
forms
of
caring
Recently,
novel
experimental
tools
provided
a
more
detailed
insight
into
function
LS,
including
specific
role
distinct
cell
types
their
neuronal
connections
behavioral
regulations,
which
participates.
This
article
discusses
regulation
different
maternal
alterations
using
distributions
established
hormones
such
as
prolactin,
estrogens,
neuropeptide
oxytocin.
It
considers
distribution
neurons
activated
mothers
response
to
pups
activities,
well
gene
expressional
LS.
Finally,
this
paper
proposes
further
research
directions
keep
up
with
rapidly
developing
knowledge
on
control
brain
regions.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 26, 2024
The
lateral
septum
(LS)
is
a
midline,
subcortical
structure,
which
regulates
social
behaviors
that
are
frequently
impaired
in
neurodevelopmental
disorders
including
schizophrenia
and
autism
spectrum
disorder.
Mouse
studies
have
identified
neuronal
populations
within
the
LS
express
variety
of
molecular
markers,
vasopressin
receptor,
oxytocin
corticotropin
releasing
hormone
control
specific
facets
behavior.
Despite
its
critical
role
regulating
behavior
notable
gene
expression
patterns,
comprehensive
profiling
human
has
not
been
performed.
Here,
we
conducted
single
nucleus
RNA-sequencing
(snRNA-seq)
to
generate
first
transcriptomic
profiles
using
postmortem
brain
tissue
samples
from
3
neurotypical
donors.
Our
analysis
5
transcriptionally
distinct
cell
types
enriched
for
Neural Regeneration Research,
Год журнала:
2023,
Номер
19(8), С. 1789 - 1801
Опубликована: Ноя. 8, 2023
JOURNAL/nrgr/04.03/01300535-202408000-00033/figure1/v/2024-02-22T141052Z/r/image-tiff
Social
dysfunction
is
a
risk
factor
for
several
neuropsychiatric
illnesses.
Previous
studies
have
shown
that
the
lateral
septum
(LS)-related
pathway
plays
critical
role
in
mediating
social
behaviors.
However,
of
connections
between
LS
and
its
downstream
brain
regions
behaviors
remains
unclear.
In
this
study,
we
conducted
three-chamber
test
using
electrophysiological
chemogenetic
approaches
mice
to
determine
how
projections
ventral
CA1
(vCA1)
influence
sociability.
Our
results
showed
gamma-aminobutyric
acid
(GABA)-ergic
neurons
were
activated
following
experience,
enhanced
by
modulation
these
neurons.
Moreover,
GABAergic
extended
their
functional
neural
via
vCA1
glutamatergic
pyramidal
neurons,
regulating
GABA
→vCA1
Glu
affected
behaviors,
which
impeded
suppressing
LS-projecting
neuronal
activity
or
inhibiting
A
receptors
vCA1.
These
findings
support
hypothesis
inputs
can
control
preferences
novelty
provide
new
insights
regarding
circuits
regulate
Translational Psychiatry,
Год журнала:
2024,
Номер
14(1)
Опубликована: Июль 15, 2024
Abstract
There
is
much
interest
in
targeting
the
activity
oxytocin
system
to
regulate
social
bonding.
However,
studies
with
exogenous
administration
of
face
caveats
its
low
stability,
poor
brain
permeability
and
insufficient
receptor
specificity.
The
use
a
small-molecule
receptor-specific
agonist
could
overcome
these
caveats.
Prior
testing
potential
effects
brain-penetrant
clinical
settings,
it
important
assess
how
such
an
would
affect
bonds
animal
models.
facultatively
monogamous
prairie
voles
(
Microtus
ochrogaster
),
capable
forming
long-term
attachments
between
adult
individuals,
are
ideal
rodent
model
for
testing.
Therefore,
series
experiments
we
investigated
recently
developed
LIT-001
on
acquisition
expression
partner
preference,
well-established
pair
bonding,
voles.
(10
mg/kg,
intraperitoneal),
as
expected,
facilitated
preference
when
administered
prior
4hr
cohabitation.
In
contrast,
while
animals
injected
vehicle
after
cohabitation
exhibited
significant
that
were
did
not
show
preference.
This
result
suggests
OXTR
activation
during
bonding
can
inhibit
difference
versus
was
due
basal
differences
experiments,
had
no
if
following
shorter
(2hr-long)
Instead,
this
agrees
hypothesis
receptors
acts
signal
presence
partner.
Our
results
indicate
pharmacological
crucially
depend
phase
attachments.
