Comparative analysis of gonadal hormone receptor expression in the house mouse, meadow vole, and prairie vole brain DOI Creative Commons
Katherine Denney, Melody V. Wu, Simón D. Sun

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: May 13, 2023

The socially monogamous prairie vole ( Microtus ochrogaster ) and promiscuous meadow pennsylvanicus are closely related, but only voles display long-lasting pair bonds, biparental care, selective aggression towards unfamiliar individuals after bonding. These social behaviors in mammals largely mediated by steroid hormone signaling the behavior network (SBN) of brain. Hormone receptors reproducible markers sex differences that can provide more information than anatomy alone, even be at odds with anatomical dimorphisms. We reasoned associated monogamy may emerge part from unique expression patterns this species, these would similar across males females or laboratory mouse. To obtain insight into developing brain, we assessed estrogen receptor alpha Esr1 ), beta Esr2 androgen Ar within SBN, using situ hybridization postnatal day 14 mice, meadow, voles. found species-specific hippocampus ventromedial hypothalamus, as well species bias principal nucleus bed stria terminalis. findings suggest observed gonadal underlie behaviors.

Language: Английский

Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species DOI Creative Commons
Robert A. Phillips, Seyun Oh, Svitlana V. Bach

et al.

iScience, Journal Year: 2025, Volume and Issue: 28(2), P. 111820 - 111820

Published: Jan. 18, 2025

The lateral septum (LS) is a midline, subcortical structure that critical regulator of social behaviors. Mouse studies have identified molecularly distinct neuronal populations within the LS, which control specific facets behavior. Despite its known molecular heterogeneity in mouse and role regulating behavior, comprehensive profiling human LS has not been performed. Here, we conducted single-nucleus RNA sequencing (snRNA-seq) to generate transcriptomic profiles compared recently collected snRNA-seq datasets. Our analyses TRPC4 as conserved marker while FREM2 enriched only LS. We also identify cell type marked by OPRM1, gene encoding μ-opioid receptor. Together, these results highlight transcriptional robust genes for

Language: Английский

Citations

2
Cingulate to septal circuitry facilitates the preference to affiliate with large peer groups DOI
Brandon A. Fricker, Malavika Murugan, Ashley W. Seifert

et al.

Current Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

5
Pallidal prototypic neuron and astrocyte activities regulate flexible reward-seeking behaviors DOI Creative Commons
Shinwoo Kang, Minsu Abel Yang,

Aubrey Bennett

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Behavioral flexibility allows animals to adjust actions changing environments. While the basal ganglia are critical for adaptation, specific role of external globus pallidus (GPe) is unclear. This study examined contributions two major GPe cell types-prototypic neurons projecting subthalamic nucleus (Proto GPe→STN neurons) and astrocytes-to behavioral flexibility. Using longitudinal operant conditioning with context reversals, we found that Proto dynamically represent contextual information correlating optimality. In contrast, astrocytes exhibited gradual encoding independent performance. Deleting impaired adaptive responses action-outcome contingencies without altering initial reward-seeking acquisition, highlighting their in enabling Furthermore, discovered integrate inhibitory striatal excitatory inputs, modulating downstream circuits support flexible behavior. research elucidates complementary roles cellular mechanisms

Language: Английский

Citations

0
Motherhood and DREADD manipulation of the nucleus accumbens weaken established pair bonds in female prairie voles DOI Creative Commons
Santiago A. Forero, Lindsay L. Sailer,

Aistė Girčytė

et al.

Hormones and Behavior, Journal Year: 2023, Volume and Issue: 151, P. 105351 - 105351

Published: March 30, 2023

Language: Английский

Citations

9
Lateral septum as a possible regulatory center of maternal behaviors DOI Creative Commons

Gina Puska,

Vivien Szendi,

Árpád Dobolyi

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 161, P. 105683 - 105683

Published: April 21, 2024

The lateral septum (LS) is involved in controlling anxiety, aggression, feeding, and other motivated behaviors. Lesion studies have also implicated the LS various forms of caring Recently, novel experimental tools provided a more detailed insight into function LS, including specific role distinct cell types their neuronal connections behavioral regulations, which participates. This article discusses regulation different maternal alterations using distributions established hormones such as prolactin, estrogens, neuropeptide oxytocin. It considers distribution neurons activated mothers response to pups activities, well gene expressional LS. Finally, this paper proposes further research directions keep up with rapidly developing knowledge on control brain regions.

Language: Английский

Citations

3
Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species DOI Creative Commons
Robert A. Phillips, Seyun Oh, Svitlana V. Bach

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 26, 2024

The lateral septum (LS) is a midline, subcortical structure, which regulates social behaviors that are frequently impaired in neurodevelopmental disorders including schizophrenia and autism spectrum disorder. Mouse studies have identified neuronal populations within the LS express variety of molecular markers, vasopressin receptor, oxytocin corticotropin releasing hormone control specific facets behavior. Despite its critical role regulating behavior notable gene expression patterns, comprehensive profiling human has not been performed. Here, we conducted single nucleus RNA-sequencing (snRNA-seq) to generate first transcriptomic profiles using postmortem brain tissue samples from 3 neurotypical donors. Our analysis 5 transcriptionally distinct cell types enriched for

Language: Английский

Citations

3
How do lateral septum projections to the ventral CA1 influence sociability? DOI Creative Commons
Dan Wang,

Di Zhao,

Wentao Wang

et al.

Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(8), P. 1789 - 1801

Published: Nov. 8, 2023

JOURNAL/nrgr/04.03/01300535-202408000-00033/figure1/v/2024-02-22T141052Z/r/image-tiff Social dysfunction is a risk factor for several neuropsychiatric illnesses. Previous studies have shown that the lateral septum (LS)-related pathway plays critical role in mediating social behaviors. However, of connections between LS and its downstream brain regions behaviors remains unclear. In this study, we conducted three-chamber test using electrophysiological chemogenetic approaches mice to determine how projections ventral CA1 (vCA1) influence sociability. Our results showed gamma-aminobutyric acid (GABA)-ergic neurons were activated following experience, enhanced by modulation these neurons. Moreover, GABAergic extended their functional neural via vCA1 glutamatergic pyramidal neurons, regulating GABA →vCA1 Glu affected behaviors, which impeded suppressing LS-projecting neuronal activity or inhibiting A receptors vCA1. These findings support hypothesis inputs can control preferences novelty provide new insights regarding circuits regulate

Language: Английский

Citations

6
Comparative analysis of gonadal hormone receptor expression in the postnatal house mouse, meadow vole, and prairie vole brain DOI
Katherine Denney, Melody V. Wu, Simón D. Sun

et al.

Hormones and Behavior, Journal Year: 2023, Volume and Issue: 158, P. 105463 - 105463

Published: Nov. 22, 2023

Language: Английский

Citations

5
Effects of oxytocin receptor agonism on acquisition and expression of pair bonding in male prairie voles DOI Creative Commons
Michael Johnson, Jonathan A. Zweig, Yangmiao Zhang

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 15, 2024

Abstract There is much interest in targeting the activity oxytocin system to regulate social bonding. However, studies with exogenous administration of face caveats its low stability, poor brain permeability and insufficient receptor specificity. The use a small-molecule receptor-specific agonist could overcome these caveats. Prior testing potential effects brain-penetrant clinical settings, it important assess how such an would affect bonds animal models. facultatively monogamous prairie voles ( Microtus ochrogaster ), capable forming long-term attachments between adult individuals, are ideal rodent model for testing. Therefore, series experiments we investigated recently developed LIT-001 on acquisition expression partner preference, well-established pair bonding, voles. (10 mg/kg, intraperitoneal), as expected, facilitated preference when administered prior 4hr cohabitation. In contrast, while animals injected vehicle after cohabitation exhibited significant that were did not show preference. This result suggests OXTR activation during bonding can inhibit difference versus was due basal differences experiments, had no if following shorter (2hr-long) Instead, this agrees hypothesis receptors acts signal presence partner. Our results indicate pharmacological crucially depend phase attachments.

Language: Английский

Citations

1
Early life social complexity shapes adult neural processing in the communal spiny mouse Acomys cahirinus DOI
Kelly J. Wallace,

Solanch Dupeyron,

Mutian Li

et al.

Psychopharmacology, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 6, 2023

Language: Английский

Citations

3