The Journal of Physiological Sciences,
Год журнала:
2024,
Номер
74(1)
Опубликована: Авг. 2, 2024
Abstract
Many
experts
have
extensively
studied
the
potential
of
exercise
as
a
treatment
option
for
psychiatric
conditions,
including
depression
and
autism
spectrum
disorder
(ASD).
Despite
their
core
symptoms,
these
conditions
exhibits
comparable
component
traits,
an
anxiety.
In
this
study,
we
explored
effect
on
behavioral
abnormalities
in
focusing
its
intensity
emotional
resilience.
Shank3B
knockout
(KO
SED
)
mice
displaying
self-injurious
repetitive
behavior
C57BL/6J
mice,
susceptible
to
stress
ASD
model,
respectively,
were
subjected
moderate-intensity
(ME)
2
weeks.
ME
mitigated
symptoms
(excessive
grooming
traits
despair)
but
did
not
exert
significant
anxiolytic
effect.
Notably,
has
emerged
critical
determinant
efficacy,
evidenced
by
lower
ventilation
threshold
mediated
low-intensity
exercise.
The
findings
substantiate
notion
that
is
promising
disease-modifying
treatment,
matters
Graphical
Frontiers in Psychiatry,
Год журнала:
2023,
Номер
14
Опубликована: Сен. 12, 2023
The
COVID-19
pandemic
has
increased
the
prevalence
of
depressive
disorders
worldwide,
requiring
alternative
treatments
beyond
medication
and
psychotherapy.
Exercise
positive
effects
on
brain;
therefore,
it
emerged
as
a
promising
therapeutic
option
for
individuals
with
depression.
Considerable
research
involving
humans
animals
offers
compelling
evidence
to
support
mental
health
benefits
physical
activity
or
exercise
mediated
by
regulation
complex
theoretical
paradigms.
However,
challenges
such
conducting
long-term
follow-up
assessments
considering
individual
characteristics
remain
in
human
studies
despite
extensive
efforts.
While
animal
provide
valuable
insights
into
potential
its
impact
outcomes
related
depression
anxiety
rodents
exposed
different
stress
paradigms,
translating
findings
requires
careful
evaluation.
More
is
needed
establish
precise
prescription
guidelines
better
understand
relationship
between
disorders.
Therefore,
this
concise
review
explores
supporting
intervention
an
antidepressant
treatment
underlying
mechanisms.
Reviews in the Neurosciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 20, 2025
Abstract
Depression
is
a
common
mental
disorder
characterized
by
high
prevalence
and
significant
adverse
effects,
making
the
searching
for
effective
interventions
an
urgent
priority.
In
recent
years,
physical
activity
(PA)
has
increasingly
been
recognized
as
standard
adjunctive
treatment
disorders
owing
to
its
low
cost,
easy
application,
efficiency.
Epidemiological
data
shows
positive
preventive
therapeutic
effects
of
PA
on
illnesses
such
depression.
This
article
systematically
describes
prophylactic
depression
biological
basis.
A
comprehensive
literature
analysis
reveals
that
significantly
improves
depressive
symptoms
upregulating
expression
“exerkines”
irisin,
adiponectin,
BDNF
positively
impacting
neuropsychiatric
conditions.
particular,
lactate
could
also
play
critical
role
in
ameliorating
due
findings
about
protein
lactylation
novel
post-transcriptional
modification.
The
suggests
terms
brain
structure,
may
improve
hippocampal
volume,
basal
ganglia
(neostriatum,
caudate-crustal
nucleus)
PFC
density
patients
with
MDD.
summary,
this
study
elucidates
multifaceted
potential
mechanisms
particular
emphasis
roles
various
exerkines.
Future
research
further
investigate
different
types,
intensities,
durations
depression,
well
how
better
integrate
into
existing
strategies
achieve
optimal
outcomes
health
interventions.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 22, 2025
Physical
exercise
effectively
prevents
anxiety
disorders
caused
by
environmental
stress.
The
neural
circuitry
mechanism,
however,
remains
incomplete.
Here,
we
identified
a
previously
unrecognized
pathway
originating
from
the
primary
motor
cortex
(M1)
to
medial
prefrontal
(mPFC)
via
ventromedial
thalamic
(VM)
nuclei
in
male
mice.
Besides
anatomical
evidence,
both
ex
vivo
and
recordings
showed
enhanced
excitability
of
M1-VM
inputs
prelimbic
(PrL)
region
mPFC
upon
14-day
treadmill
on
chronic
restraint
stress
(CRS)
mouse
model.
Further
functional
interrogations
demonstrated
that
activation
this
circuit
is
necessary
sufficient
direct
anxiolytic
effect
training
CRS
Our
findings
provide
more
insights
into
circuits
connecting
mental
regions
under
paradigm
implicate
potential
targets
for
neuromodulation
treating
disorders.
relieves
disorders,
while
authors
show
input
cortex,
nuclei.
This
study
investigates
the
association
between
Weekend
Warrior
(WW)
pattern
and
risk
of
anxiety
among
American
adults,
offering
insights
into
a
more
flexible
exercise
strategy
for
individuals
with
limited
time
regular
during
weekdays.
We
analyzed
data
from
2007–2012
National
Health
Nutrition
Examination
Survey
(NHANES)
to
examine
relationship
different
physical
activity
(PA)
patterns
anxiety.
Multivariate
logistic
regression,
subgroup
interaction,
restricted
cubic
spline
analysis
(RCS),
sensitivity
analyses
were
conducted
assess
this
association.
Compared
inactive
individuals,
those
engaging
in
WW
(OR
=
0.65,
95%
CI:
0.48–0.90,
p
0.010),
insufficiently
active
0.71,
0.62–0.82,
<
0.001),
or
regularly
0.75,
0.65–0.87,
0.001)
showed
significantly
lower
Subgroup
interaction
revealed
significant
effect
modification
poverty
income
ratio
(PIR)
diabetes
subgroups
(P
0.05),
while
no
interactions
observed
other
variables.
RCS
nonlinear
recreational
moderate
vigorous
intensity
0.001).
Sensitivity
further
confirmed
stability
findings.
The
was
associated
For
unable
consistently
throughout
week,
offers
practical
alternative
reducing
anxiety,
particularly
levels
diabetes.
Journal of Advanced Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Disruption
of
cerebral
energy
metabolism
is
increasingly
recognized
as
a
key
factor
in
the
pathophysiology
mood
disorders.
Lactate,
beyond
its
role
metabolic
byproduct,
now
understood
to
be
critical
player
brain
homeostasis
and
modulator
neuronal
function.
Recent
advances
understanding
lactate
shuttling
between
astrocytes
neurons
have
opened
new
avenues
for
exploring
multifaceted
roles
regulation.
Exercise,
known
modulate
levels,
further
underscores
potential
therapeutic
target
This
review
delves
into
alterations
associated
with
disorders,
emphasizing
their
implications
dynamics
signaling
pathways.
Additionally,
we
discuss
particularly
through
capacity
remodel
We
conclude
by
assessing
promise
exercise-induced
production
novel
strategy
disorder
treatment.
Alterations
may
contribute
pathogenesis
In
several
studies,
not
only
substrate
metabolism,
but
also
molecule
that
triggers
cascades.
Specifically,
involved
regulation
neurogenesis,
neuroplasticity,
endothelial
cell
function,
microglia
lysosomal
acidification,
therefore
improving
Meanwhile,
exercise
low-risk
intervention
can
improve
disorders
Thus,
evidence
from
this
supports
could
disorder,
contributing
deeper
intervention.
Frontiers in Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Март 22, 2024
Background
Anxiety
and
depression
are
prevalent
mental
disorders.
As
modern
society
continues
to
face
mounting
pressures,
the
incidence
of
anxiety
is
on
rise.
In
recent
years,
there
has
been
an
increasing
breadth
research
exploring
relationship
between
anxiety,
depression,
physical
activity
(PA).
However,
current
progress
future
development
trends
unclear.
The
purpose
this
study
explore
hotspots
in
field,
provide
guidance
for
studies
some
reference
clinicians.
Methods
We
searched
relevant
literature
Web
Science
Core
Collection
from
establishment
database
August
15,
2023.
CiteSpace,
VOSviewer
Bibliometrix
Packages
based
R
language
were
used
analyze
number
publications,
countries,
institutions,
journals,
authors,
references,
keywords.
Results
A
total
1,591
included
analysis,
field
PA
or
consistently
expanded.
USA
(304
publications),
Harvard
University
(93
journal
affective
disorders
(97
publications)
journals
that
published
highest
articles,
respectively.
According
keywords,
students
pregnant
women,
adult
neurogenesis,
Tai
Chi
groups
concern,
physiological
pathological
mechanisms,
type
interest,
Conclusion
experiencing
ongoing
expansion.
Clinicians
can
consider
advising
patients
take
mind–body
exercise
improve
mood.
addition,
researchers
its
impact
specific
populations,
neurogenesis
various
depression.
Neurotoxicology and Teratology,
Год журнала:
2024,
Номер
103, С. 107353 - 107353
Опубликована: Апрель 21, 2024
Aversive
caregiving
in
early
life
is
a
risk
factor
for
aberrant
brain
and
behavioral
development.
This
outcome
related
to
epigenetic
dysregulation
of
the
brain-derived
neurotrophic
(Bdnf)
gene.
The
Bdnf
gene
encodes
BDNF,
neurotrophin
involved
development,
neural
plasticity,
learning,
memory.
Recent
work
suggests
that
exercise
may
be
neuroprotective
part
by
supporting
BDNF
protein
expression,
making
it
an
exciting
target
therapeutic
interventions.
To
our
knowledge,
has
never
been
studied
as
intervention
preclinical
rodent
models
caregiver
maltreatment.
end,
current
study
investigated
effect
adult
voluntary
wheel
running
on
methylation
expression
prefrontal
cortex
rats
who
experienced
aversive
infancy.
We
employed
model
(Long
Evans
rats)
wherein
rat
pups
intermittent
caregiver-induced
stress
from
postnatal
days
1–7
were
given
access
(except
control
condition)
70–90
young
adulthood
treatment
intervention.
Our
results
indicate
maltreatment
affect
exon,
CG
site,
sex-specific
manner.
Here
we
add
growing
body
evidence
ability
experiences,
including
exercise,
permeate
brain.
Keywords:
Early
stress,
Bdnf,
cortex.
Frontiers in Psychiatry,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 27, 2024
Maternal
exposure
to
inflammation
is
one
of
the
causes
autism
spectrum
disorder
(ASD).
Electrical
stimulation
vagus
nerve
exerts
a
neuroprotective
effect
via
its
anti-inflammatory
action.
We
thus
investigated
whether
transcutaneous
auricular
(taVNS)
can
enhance
social
abilities
in
mouse
model
ASD
induced
by
maternal
immune
activation
(MIA).
