Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Март 14, 2023
Abstract
Cardiac
aging
is
evident
by
a
reduction
in
function
which
subsequently
contributes
to
heart
failure.
The
metabolic
microenvironment
has
been
identified
as
hallmark
of
malignancy,
but
recent
studies
have
shed
light
on
its
role
cardiovascular
diseases
(CVDs).
Various
pathways
cardiomyocytes
and
noncardiomyocytes
determine
cellular
senescence
the
heart.
Metabolic
alteration
common
process
throughout
cardiac
degeneration.
Importantly,
involvement
injuries,
including
failure
myocardial
ischemia
infarction,
reported.
However,
complexity
among
human
hearts
hinders
development
strategies
that
targets
susceptibility.
Advances
over
past
decade
linked
with
their
reprogramming
pathway
aging,
autophagy,
oxidative
stress,
epigenetic
modifications,
chronic
inflammation,
myocyte
systolic
phenotype
regulation.
In
addition,
status
involved
crucial
aspects
biology,
from
fibrosis
hypertrophy
inflammation.
further
elucidation
metabolism
degeneration
still
needed.
Thus,
deciphering
mechanisms
underlying
how
impacts
thought
contribute
novel
interventions
protect
or
even
restore
hearts.
Here,
we
summarize
emerging
concepts
about
landscapes
specific
focuses
why
profile
alters
during
could
utilize
current
knowledge
improve
management
aging.
Signal Transduction and Targeted Therapy,
Год журнала:
2020,
Номер
5(1)
Опубликована: Окт. 7, 2020
Abstract
Nicotinamide
adenine
dinucleotide
(NAD
+
)
and
its
metabolites
function
as
critical
regulators
to
maintain
physiologic
processes,
enabling
the
plastic
cells
adapt
environmental
changes
including
nutrient
perturbation,
genotoxic
factors,
circadian
disorder,
infection,
inflammation
xenobiotics.
These
effects
are
mainly
achieved
by
driving
effect
of
NAD
on
metabolic
pathways
enzyme
cofactors
transferring
hydrogen
in
oxidation-reduction
reactions.
Besides,
multiple
-dependent
enzymes
involved
physiology
either
post-synthesis
chemical
modification
DNA,
RNA
proteins,
or
releasing
second
messenger
cyclic
ADP-ribose
(cADPR)
NAADP
.
Prolonged
disequilibrium
metabolism
disturbs
physiological
functions,
resulting
diseases
diseases,
cancer,
aging
neurodegeneration
disorder.
In
this
review,
we
summarize
recent
advances
our
understanding
molecular
mechanisms
-regulated
responses
stresses,
contribution
deficiency
various
via
manipulating
cellular
communication
networks
potential
new
avenues
for
therapeutic
intervention.
Signal Transduction and Targeted Therapy,
Год журнала:
2020,
Номер
5(1)
Опубликована: Окт. 7, 2020
Abstract
Nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
is
an
essential
electron
donor
in
all
organisms,
and
provides
the
reducing
power
for
anabolic
reactions
redox
balance.
NADPH
homeostasis
regulated
by
varied
signaling
pathways
several
metabolic
enzymes
that
undergo
adaptive
alteration
cancer
cells.
The
reprogramming
of
renders
cells
both
highly
dependent
on
this
network
antioxidant
capacity
more
susceptible
to
oxidative
stress.
Modulating
unique
might
be
effective
strategy
eliminate
these
In
review,
we
summarize
current
existing
literatures
homeostasis,
including
its
biological
functions,
regulatory
mechanisms
corresponding
therapeutic
interventions
human
cancers,
providing
insights
into
implications
targeting
metabolism
associated
mechanism
therapy.
Science,
Год журнала:
2021,
Номер
372(6547), С. 1224 - 1229
Опубликована: Апрель 22, 2021
Anti-aging
supplement
effects
in
humans
Synthesis
of
nicotinamide
adenine
dinucleotide
(NAD
+
)
decreases
during
aging,
which
is
thought
to
limit
the
activity
enzymes
that
require
it
for
their
catalytic
activity.
Studies
animals
indicate
replenishment
cellular
NAD
can
have
beneficial
on
aging
and
age-related
diseases,
but
situation
less
clear.
Yoshino
et
al.
report
supplementation
with
precursor
mononucleotide
overweight
or
obese
postmenopausal
women
prediabetes
(see
Perspective
by
Hepler
Bass).
The
treatment
improved
insulin
sensitivity
muscle,
although
a
change
content
was
not
detected.
also
increased
expression
platelet-derived
growth
factor
b.
results
support
potential
therapeutic
action
humans,
how
various
NAD+
precursors
are
processed
specific
tissues
remains
be
fully
explored.
Science
,
abe9985,
this
issue
p.
1224
;
see
abj0764,
1147
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Фев. 16, 2024
Abstract
The
human
gastrointestinal
tract
is
populated
with
a
diverse
microbial
community.
vast
genetic
and
metabolic
potential
of
the
gut
microbiome
underpins
its
ubiquity
in
nearly
every
aspect
biology,
including
health
maintenance,
development,
aging,
disease.
advent
new
sequencing
technologies
culture-independent
methods
has
allowed
researchers
to
move
beyond
correlative
studies
toward
mechanistic
explorations
shed
light
on
microbiome–host
interactions.
Evidence
unveiled
bidirectional
communication
between
central
nervous
system,
referred
as
“microbiota–gut–brain
axis”.
microbiota–gut–brain
axis
represents
an
important
regulator
glial
functions,
making
it
actionable
target
ameliorate
development
progression
neurodegenerative
diseases.
In
this
review,
we
discuss
mechanisms
As
provides
essential
cues
microglia,
astrocytes,
oligodendrocytes,
examine
communications
microbiota
these
cells
during
healthy
states
Subsequently,
diseases
using
metabolite-centric
approach,
while
also
examining
role
microbiota-related
neurotransmitters
hormones.
Next,
targeting
intestinal
barrier,
blood–brain
meninges,
peripheral
immune
system
counteract
dysfunction
neurodegeneration.
Finally,
conclude
by
assessing
pre-clinical
clinical
evidence
probiotics,
prebiotics,
fecal
transplantation
A
thorough
comprehension
will
foster
effective
therapeutic
interventions
for
management
