Diabetes Obesity and Metabolism, Год журнала: 2024, Номер unknown
Опубликована: Дек. 27, 2024
Язык: Английский
Cell Metabolism, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Journal of Hepatology, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
The liver acts as a central metabolic hub, integrating signals from the gastrointestinal tract and adipose tissue to regulate carbohydrate, lipid, amino acid metabolism. Gut-derived metabolites, such acetate ethanol non-esterified fatty acids white (WAT), influence hepatic processes, which rely on mitochondrial function maintain systemic energy balance. Metabolic dysregulation obesity, insulin resistance, type 2 diabetes disrupt these pathways, leading dysfunction-associated steatotic disease (MASLD) steatohepatitis (MASH). This review explores fluxes within gut-adipose tissue-liver axis, focusing pivotal role of de novo lipogenesis (DNL), dietary substrates like glucose fructose, changes in during MASLD progression. It highlights contributions resistance impaired dynamics lipid accumulation. Further understanding how interplay between substrate flux gastro-intestinal integrates with intersects structural functional alterations mitochondria will be important identify novel therapeutic targets advance treatment MASH.
Язык: Английский
Процитировано
1
Physiological Reports, Год журнала: 2024, Номер 12(16)
Опубликована: Авг. 1, 2024
Abstract Modulation of testing conditions such as resting lactate (La rest ) levels or carbohydrate intake may affect the calculation maximal glycolytic rate (νLa.max). To evaluate impact elevated La well reduced and increased availability on νLa.max in running sprints (RST), twenty‐one participants completed five 15‐s RST tests a track under different conditions: (I). baseline: ≤1.5 mmol·L −1 ; (II). Lactate+: ≥2.5 (III). CHO − : intake: ≤ 1 g·kg BW d for 3 days; (IV). CHO+: ≥ 9 one day; (V). acuteCHO: 500 mL glucose containing beverage consumed before RST. was significantly lactate+ CHO− compared to baseline RST, due reduction arithmetic mean delta (∆) between peak concentration , mmol · L ). AcuteCHO led an increase baseline, CHO+ with high interindividual variability but did not reduce νLa.max. Therefore, avoiding low nutrition testing, along carefully adjusting below mmol·L‐1, is crucial prevent unintentional underestimation
Язык: Английский
Процитировано
5
Molecules, Год журнала: 2025, Номер 30(8), С. 1763 - 1763
Опубликована: Апрель 15, 2025
The “Warburg effect” is a term coined century ago for the preferential use of glycolysis over aerobic respiration in tumor cells energy production, even under conditions. Although this less efficient mechanism generating from glucose, glycolysis, addition to canonical anaerobic an effective means lactate production. abundant waste product, lactate, yielded by dual tumor, has been discovered be major biomolecule that drives cancer progression. Lactate metabolic source that, via cell membrane transporters, shuttles and out as well cell-associated stromal immune within microenvironment (TME). Additionally, serves pH tuner, signaling ligand transducer, epigenetic gene transcription regulator, TME modifier, suppressor, chemoresistance modulator, prognostic marker. With such broad functionalities, production–consumption–reproduction fuels growth dissemination. Here, we elaborate on sources contribute pool TME, functions influence function local tissue immunity, anticancer therapeutic approaches adopting manipulations their efficacies. By scrutinizing these properties others have addressed field, it expected better weighing development, progression, prognosis, efficacy can achieved.
Язык: Английский
Процитировано
0
AJP Endocrinology and Metabolism, Год журнала: 2024, Номер 327(2), С. E217 - E228
Опубликована: Июнь 19, 2024
Our purpose was to determine how age affects metabolic flexibility and underlying glucose kinetics in healthy young older adults. Therefore, lactate tracers along with pulmonary gas exchange data were used respiratory ratios [RER = carbon dioxide production (V̇co
Язык: Английский
Процитировано
1
Journal of Applied Physiology, Год журнала: 2024, Номер 137(4), С. 857 - 863
Опубликована: Авг. 1, 2024
Muscular efficiency during exercise has been used to interrogate aspects of human muscle energetics, including mitochondrial coupling and biomechanical efficiencies. Typically, assessments muscular have involved graded exercises. Results previous studies interpreted indicate a decline in with aging owing decreased function. However, discrepancies variables such as stage duration, cycling cadence, treadmill walking mechanics may affected interpretations results. Furthermore, recent data from our lab examining the ATP oxygen ratio (P:O) preparations isolated NIA mouse skeletal showed no change aging. Thus, we hypothesized that delta (Δ€) steady-rate would not be altered older healthy subjects compared young counterparts regardless biological sex or training status. Young (21-35 yr) (60-80 men (
Язык: Английский
Процитировано
0
AJP Endocrinology and Metabolism, Год журнала: 2024, Номер 327(4), С. E430 - E440
Опубликована: Авг. 7, 2024
We used isotope tracers, an oral glucose tolerance test, and arterialized blood sampling to determine postprandial lactate flux rates in healthy young older men women. Lactate of appearance oxidation the lactate‐pyruvate exchange were delayed diminished both enteric systemic shuttle phases participants.
Язык: Английский
Процитировано
0
Diabetes Obesity and Metabolism, Год журнала: 2024, Номер unknown
Опубликована: Дек. 27, 2024
Язык: Английский
Процитировано
0