medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 26, 2024
Early
Life
Adversity
(ELA)
has
been
linked
to
accelerated
epigenetic
aging.
While
positive
parenting
is
hypothesized
buffer
the
detrimental
effects
of
ELA
on
child
development,
its
role
in
mitigating
age
acceleration
remains
unclear.
Data
from
2,039
children
(49.7%
female)
Future
Families
and
Child
Wellbeing
Study
(FFCWS)
were
included
current
study
(46.7%
Black,
26.5%
Hispanic,
19%
White
non-Hispanic).
Home
community
threat
observed
measured
ages
3
9.
Salivary
was
at
9
15.
Positive
reduces
pace
aging
low,
but
not
high,
community-threat
environments.
Interventions
across
home
environments
may
be
necessary
prevent
ELA's
biological
embedding.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
One-carbon
metabolism
(OCM),
a
biochemical
pathway
dependent
on
micronutrients
including
folate
and
vitamin
B12,
plays
an
essential
role
in
aging-related
physiological
processes.
DNA
methylation-based
aging
biomarkers
may
be
influenced
by
OCM.
This
study
investigated
associations
of
OCM-related
with
epigenetic
the
National
Health
Nutrition
Examination
Survey
(NHANES).
Blood
methylation
was
measured
adults
aged
≥50
years
1999-2000
2001-2002
cycles
NHANES.
The
following
were
included:
Horvath1,
Horvath2,
Hannum,
PhenoAge,
GrimAge2,
DunedinPoAm,
telomere
length
(DNAmTL).
We
tested
for
serum
folate,
red
blood
cell
(RBC)
homocysteine,
methylmalonic
acid
concentrations
age
deviation
(EAD)
among
2,346
participants
nutritional
status
using
survey
weighted
general
linear
regression
models
adjusting
sociodemographics,
BMI,
behavioral
factors.
A
doubling
concentration
associated
-0.82
(95%
confidence
interval
(CI)
=
-1.40,
-0.23)
lower
GrimAge
EAD,
-0.13
SDs
(-0.22,
-0.03)
0.02
kb
(0.00,
0.04)
greater
DNAmTL
EAD.
Associations
attenuated
after
smoking
alcohol
intake,
antagonists.
Conversely,
homocysteine
1.05
(0.06,
2.04)
PhenoAge
1.93
(1.16,
2.71)
GrimAge2
0.26
(0.10,
0.41)
DunedinPoAm.
EAD
DunedinPoAm
robust
to
adjustment.
In
nationally
representative
sample
U.S.
adults,
carbon
donor,
indicator
OCM
deficiencies,
EAD;
however,
some
status.
Future
research
should
focus
high-risk
populations.
Randomized
controlled
trials
long-term
follow-up
are
also
needed
established
causality
investigate
clinical
relevance
changes
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 12, 2025
Using
a
modified
Delphi
process,
we
engaged
28
experts
in
clinical
trials,
geriatrics,
and
research
translation
to
determine
if
there
were
consensus
around
what
endpoints
should
be
used
for
trials
evaluating
the
efficacy
of
interventions
prevent
or
treat
multiple
age-related
conditions.
Four
focus
groups
developed
themes.
Statements
related
those
themes
circulated
back
participants
survey.
There
was
(more
than
66%
agreed
disagreed)
that
outcome
measures
include
health
dimensions
including-age-related
disease,
function
patient
reported
outcomes
reflect
goals;
tailored
population
characteristics.
Experts
felt
blood-based
biomarkers
would
unlikely
accepted
as
primary
trials.
Plausible
components
mentioned
part
composite
endpoint
included
mortality,
mobility
onset
diseases.
Our
findings
provide
guidance
on
acceptable
approaches
selection
guiding
design
future
geroscience
Biomarkers
of
aging
are
indispensable
for
testing
interventions.
While
promising,
the
recent
focus
on
molecular
aspects
should
not
detract
from
functional
parameters
which
excellent
correlation
with
mortality,
and
ample
clinical
human
data
exist.
International Journal of Dermatology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
ABSTRACT
The
concept
of
aging
has
evolved
from
being
primarily
attributed
to
genetic
factors
recognizing
the
critical
role
epigenetic
mechanisms.
Recent
advancements,
such
as
clocks,
have
provided
tools
assess
biological
age
and
offer
insights
into
processes
at
molecular
level.
In
aesthetic
dermatology,
understanding
these
allows
for
more
personalized,
effective
interventions
targeting
root
causes
skin
aging.
This
review
explores
interplay
changes,
aging,
potential
personalized
care
enhance
longevity
rejuvenation.
is
based
on
an
extensive
literature
search
conducted
across
PubMed
other
scientific
databases.
Studies
focused
mechanisms
DNA
methylation,
histone
modifications,
their
relationship
Particular
attention
was
given
recent
advancements
in
including
Horvath's
Clock
GrimAge,
implications
dermatological
treatments.
Epigenetic
Clock,
demonstrated
utility
assessing
through
methylation
markers,
revealing
actionable
processes.
Energy‐based
devices
like
fractional
lasers
radiofrequency
shown
promise
reversing
age‐related
promoting
collagen
synthesis,
reducing
age.
Additionally,
lifestyle
diet,
sleep,
circadian
rhythm
alignment
significantly
influence
health.
Integrating
dermatology
represents
a
paradigm
shift
rejuvenation,
allowing
treatments
that
address
visible
signs
underlying
Using
clocks
provides
framework
tailoring
individual
patient
needs,
optimizing
outcomes,
extending
results.
Future
research
should
focus
longitudinal
studies,
accessibility,
ethical
considerations
fully
harness
epigenetics
health
overall
well‐being.
Clinical Proteomics,
Год журнала:
2025,
Номер
22(1)
Опубликована: Март 18, 2025
One
of
the
main
causes
morbidity
and
death
in
pediatric
patients
is
sepsis.
Of
48.9
million
cases
sepsis
reported
globally,
41.5%
involve
children
under
age
five,
with
2.9
deaths
associated
disease.
Clinicians
must
identify
treat
at
risk
or
septic
shock
before
late-stage
organ
dysfunction
occurs
since
diagnosing
young
more
difficult
than
adult
patients.
As
right
now,
omics
technologies
that
possess
adequate
diagnostic
sensitivity
specificity
can
assist
locating
biomarkers
indicate
how
disease
will
progress
clinically
patient
react
to
treatment.
By
identifying
who
are
a
higher
dying
experiencing
persistent
dysfunction,
stratification
based
on
generated
from
proteomics
enhance
prognosis.
A
potentially
helpful
method
for
determining
proteins
serve
as
formulating
theories
pathophysiological
mechanisms
behind
complex
symptoms
plasma
proteomics.
Aging advances.,
Год журнала:
2024,
Номер
1(2), С. 118 - 134
Опубликована: Дек. 1, 2024
Aging
is
a
complex
biological
process
characterized
by
gradual
deterioration
in
physiological
activities,
contributing
to
an
elevated
risk
of
different
age-associated
malignancies,
including
cancer.
The
current
review
paper
aims
elucidate
the
association
between
hallmarks
aging
and
parallel
development
Various
cellular
molecular
mechanisms
underlying
such
as
senescence,
genomic
instability,
telomere
shortening
play
significant
role
accumulation
genetic
mutations
disruption
activities.
It
has
also
discussed
immune
system’s
aging,
indicating
how
age-linked
dysfunction
compromises
body’s
capacity
recognize
eradicate
pre-tumorous
cells,
thus
promoting
cancer
advancement.
This
examines
affects
tumor
microenvironment,
where
age-related
alterations
stromal
extracellular
matrix
factors
lead
conditions
that
promote
growth
proliferation.
Furthermore,
it
discusses
concept
“accelerated
aging”
survivors,
highlighting
negative
effects
its
therapy
intensify
process,
resulting
greater
physical
cognitive
decline.
explores
prospect
new
therapies
target
aging-related
processes
ameliorate
outcomes.
Overall,
underscores
need
for
ongoing
interdisciplinary
research
understand
relationship
cancer,
ultimately
aiming
develop
more
effective
prevention
treatment
approaches.
