Enantioselective photocatalytic synthesis of bicyclo[2.1.1]hexanes as ortho-disubstituted benzene bioisosteres with improved biological activity
Nature Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
Язык: Английский
Alkyl Azetidines Via Batch and Flow Photochemistry
Oleksandr Datsenko,
Andrii Baziievskyi,
Iryna V. Sadkova
и другие.
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 4, 2025
Alkyl
azetidines
have
been
prepared
by
photochemical
modifications
of
azetidine-2-carboxylic
acids
in
batch
and
flow.
The
reaction
has
realized
milligram,
gram,
even
multigram
quantities.
obtained
are
valuable
building
blocks
for
drug
discovery.
Язык: Английский
Rapid access to 3-substituted bicyclo[1.1.1]pentanes
Chem,
Год журнала:
2025,
Номер
unknown, С. 102537 - 102537
Опубликована: Апрель 1, 2025
Язык: Английский
CF3-Cyclobutanes: Synthesis, Properties, and Evaluation as a Unique tert-Butyl Group Analogue
JACS Au,
Год журнала:
2024,
Номер
4(11), С. 4507 - 4517
Опубликована: Ноя. 11, 2024
Isosteric
replacement
of
functional
groups
is
an
emerging
strategy
for
optimizing
bioactive
molecules
in
drug
discovery.
Язык: Английский
Synthesis of Functionalized Methyl-Substituted Bicyclo[1.1.1]pentanes
French-Ukrainian Journal of Chemistry,
Год журнала:
2024,
Номер
12(1), С. 111 - 117
Опубликована: Янв. 1, 2024
Synthesis
of
new
functionalized
methyl-substituted
bicyclo[1.1.1]pentanes
for
medicinal
chemistry
is
presented.
All
the
products
were
obtained
in
multigram
quantities
with
decent
yields.
The
synthetic
approaches
reported
are
facile
and
scalable.
We
hope
that
this
work
will
help
process
chemists
at
pharmaceutical
companies
preparation
bioactive
suggested
by
clinical
trials.
Язык: Английский