Synthesis of Functionalized Methyl-Substituted Bicyclo[1.1.1]pentanes DOI Creative Commons
Vasyl Ripenko, Tatyana V. Yegorova

French-Ukrainian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 12(1), P. 111 - 117

Published: Jan. 1, 2024

Synthesis of new functionalized methyl-substituted bicyclo[1.1.1]pentanes for medicinal chemistry is presented. All the products were obtained in multigram quantities with decent yields. The synthetic approaches reported are facile and scalable. We hope that this work will help process chemists at pharmaceutical companies preparation bioactive suggested by clinical trials.

Language: Английский

Enantioselective photocatalytic synthesis of bicyclo[2.1.1]hexanes as ortho-disubstituted benzene bioisosteres with improved biological activity DOI
Pablo Garrido-García, Irene Quirós, Paula Milán-Rois

et al.

Nature Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

Citations

1
Alkyl Azetidines Via Batch and Flow Photochemistry DOI

Oleksandr Datsenko,

Andrii Baziievskyi,

Iryna V. Sadkova

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Alkyl azetidines have been prepared by photochemical modifications of azetidine-2-carboxylic acids in batch and flow. The reaction has realized milligram, gram, even multigram quantities. obtained are valuable building blocks for drug discovery.

Language: Английский

Citations

0
Rapid access to 3-substituted bicyclo[1.1.1]pentanes DOI

Katherine I. Burton,

David W. C. MacMillan

Chem, Journal Year: 2025, Volume and Issue: unknown, P. 102537 - 102537

Published: April 1, 2025

Language: Английский

Citations

0
CF3-Cyclobutanes: Synthesis, Properties, and Evaluation as a Unique tert-Butyl Group Analogue DOI Creative Commons

Volodymyr Ahunovych,

Anton A. Klipkov, Maksym Ya. Bugera

et al.

JACS Au, Journal Year: 2024, Volume and Issue: 4(11), P. 4507 - 4517

Published: Nov. 11, 2024

Isosteric replacement of functional groups is an emerging strategy for optimizing bioactive molecules in drug discovery.

Language: Английский

Citations

1
Synthesis of Functionalized Methyl-Substituted Bicyclo[1.1.1]pentanes DOI Creative Commons
Vasyl Ripenko, Tatyana V. Yegorova

French-Ukrainian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 12(1), P. 111 - 117

Published: Jan. 1, 2024

Synthesis of new functionalized methyl-substituted bicyclo[1.1.1]pentanes for medicinal chemistry is presented. All the products were obtained in multigram quantities with decent yields. The synthetic approaches reported are facile and scalable. We hope that this work will help process chemists at pharmaceutical companies preparation bioactive suggested by clinical trials.

Language: Английский

Citations

0