The brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Май 23, 2024

Abstract Cross-sectional studies have demonstrated strong associations between physical frailty and depression. However, the evidence from prospective is limited. Here, we analyze data of 352,277 participants UK Biobank with 12.25-year follow-up. Compared non-frail individuals, pre-frail frail individuals increased risk for incident depression independent many putative confounds. Altogether, account 20.58% 13.16% cases by population attributable fraction analyses. Higher risks are observed in males younger than 65 years their counterparts. Mendelian randomization analyses support a potential causal effect on Associations also inflammatory markers, brain volumes, Moreover, these regional volumes three markers—C-reactive protein, neutrophils, leukocytes—significantly mediate Given scarcity curative treatment high disease burden, identifying modifiable factors depression, such as frailty, needed.

Язык: Английский

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Lifestyle factors and their relative contributions to longitudinal progression of cardio-renal-metabolic multimorbidity: a prospective cohort study

Cardiovascular Diabetology, Год журнала: 2024, Номер 23(1)

Опубликована: Июль 18, 2024

Abstract Background The role of lifestyle factors and their relative contributions to the development mortality cardio-renal-metabolic multimorbidity (CRMM) remains unclear. Methods A study was conducted with 357,554 UK Biobank participants. CRMM defined as coexistence two or three diseases (CRMDs), including cardiovascular disease (CVD), type 2 diabetes (T2D) chronic kidney (CKD). prospective examined associations individual combined scores (diet, alcohol consumption, smoking, physical activity, sedentary behavior, sleep duration social connection) longitudinal progression from healthy first (FCRMD), then CRMM, ultimately death, using a multistate model. Subsequently, quantile G-computation employed assess contribution each factor. Results During median follow-up 13.62 years, played crucial in all transitions FCRMD, death. hazard ratios (95% CIs) per score increase were 0.91 (0.90, 0.91) 0.90 (0.89, for FCRMD 0.84 (0.83, 0.86), 0.87 (0.86, 0.89), (0.88, 0.93) risk healthy, respectively. Among seven factors, smoking status contributed high proportions whole progression, accounting 19.88–38.10%. High-risk diet largest proportion transition 22.53%. Less-frequent connection 28.81%. When we further consider disease-specific transitions, find that had slightly stronger T2D than CVD CKD. Conclusions Our indicates may have protective effect throughout informing more effective management treatment. Smoking status, diet, pivotal roles specific transitions.

Язык: Английский

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Brain, lifestyle and environmental pathways linking physical and mental health

Nature Mental Health, Год журнала: 2024, Номер 2(10), С. 1250 - 1261

Опубликована: Авг. 9, 2024

Язык: Английский

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Prediction of depressive symptoms severity based on sleep quality, anxiety, and gray matter volume: a generalizable machine learning approach across three datasets

EBioMedicine, Год журнала: 2024, Номер 108, С. 105313 - 105313

Опубликована: Сен. 9, 2024

Язык: Английский

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Exploring Associations between Dual Sensory Impairment and Neuropsychiatric Disorders: Insights from a Prospective Cohort Study in the UK Biobank

Опубликована: Янв. 1, 2025

Язык: Английский

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Post-traumatic stress disorder, metabolic syndrome, diabetic distress, and vitamin B1/benfotiamine

INTERNATIONAL NEUROLOGICAL JOURNAL, Год журнала: 2025, Номер 21(1), С. 96 - 107

Опубликована: Март 20, 2025

A person with post-traumatic stress disorder (PTSD) is more likely to develop metabolic syndrome (MetS), depression, and diabetic distress. It also raises the risk of cardiometabolic neurodegenerative diseases (NDD). At same time, type 2 diabetes mellitus MetS can cause development core neurosis-like psychiatric symptoms characteristic PTSD. Chronic associated cardiovascular diseases, diabetes, NDD. More people think that mitochondrial dysfunction, peripheral/central chronic low-grade inflammation (CLGI), oxidative are main causes these diseases. Pathophysiological processes link them together. To make things better for patients, interventions aim control CLGI may be better, following ideas precision medicine. Deficiency certain biofactors, in particular, vitamin B1, an increased MetS, Targeted effects on CLGI, stress, metabolism disorders suggest use antioxidants, particularly B1/benfotiamine (BFT), have a positive effect not only course comorbid but manifestations Exogenous or BFT, corrects thiamine status disorders. BFT exhibits potent animal models NDD, stress-induced anxiety, aggression, depression. Thus, considered potentially safe cost-effective drug treatment many central nervous system Despite its aspects, therapeutic potential remains limited, as beneficial require high doses over long period time. Dibenzoylthiamine, lipophilic form has been shown anti-inflammatory antioxidant at much lower than both vitro vivo. However, preclinical clinical studies needed sure viability dibenzoylthiamine. This review pays extra attention analysis features biological role mechanism action, especially impact glucose function, state neuroinflammation, how dibenzoylthiamine protect neurons. We conducted search Scopus, Science Direct (from Elsevier), PubMed, MEDLINE databases. The keywords used were “thiamine”, “benfotiamine”, “dibenzoylthiamine”, “post-traumatic disorder”, “metabolic syndrome”, “diabetic distress”, “diabetes mellitus”. manual bibliography publications pinpoint research results eluded online search.

Язык: Английский

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The inflammatory and genetic mechanisms underlying the cumulative effect of co-occurring pain conditions on depression

Science Advances, Год журнала: 2025, Номер 11(14)

Опубликована: Апрель 2, 2025

Chronic pain conditions frequently coexist and share common genetic vulnerabilities. Despite evidence showing associations between depression, the additive effect of co-occurring on depression risk underlying mechanisms remain unclear. Leveraging data from 431,038 UK Biobank participants with 14-year follow-up, we found a significantly increased incidence in individuals reporting pain, irrespective body site or duration (acute chronic), compared pain-free individuals. The number sites. Mendelian randomization supported potential causal inference. We constructed composite score by combining individual effects acute chronic across eight sites weighted manner. that risks monotonically parallel scores. Moreover, some inflammatory markers, including C-reactive protein, partially mediated association scores risk. Considering high prevalence comorbid screening may help identify high-risk for depression.

Язык: Английский

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The association between dietary quality, sleep duration, and depression symptoms in the general population: findings from cross-sectional NHANES study

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Сен. 27, 2024

Язык: Английский

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Higher amplitudes of visual networks are associated with trait- but not state-depression

Psychological Medicine, Год журнала: 2025, Номер unknown, С. 1 - 12

Опубликована: Янв. 6, 2025

Despite depression being a leading cause of global disability, neuroimaging studies have struggled to identify replicable neural correlates or explain limited variance. This challenge may, in part, stem from the intertwined state (current symptoms; variable) and trait (general propensity; stable) experiences depression.Here, we sought disentangle by leveraging longitudinal cohort stratifying individuals into four groups: those remission ('trait group'), with large severity changes symptomatology ('state their respective matched control groups (total analytic

Язык: Английский

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Magnetic resonance imaging signatures of neuroinflammation in major depressive disorder with religious and spiritual problems

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 13, 2025

Abstract Religious and spiritual (R/S) struggles, such as questioning of faith, existential ethical concerns, interpersonal conflicts, are associated with depressive symptoms. Neuroinflammation is critical in major disorder (MDD) linked to stress R/S problems. This study aimed investigate whether the presence DSM-5 problems contributes neuroinflammation. We recruited 93 MDD patients healthy controls without MRI-based restricted fraction (RF) values, an index neuroinflammation, were measured hippocampus, amygdala, neocortex. Depression anxiety assessed using Hamilton Anxiety Rating Scales (HAM-D, HAM-A), while quantified Spiritual Struggles Scale (RSS-14). Results revealed elevated RF values amygdala hippocampus individuals relative those problems, highest Importantly, symptoms independent predictors but not cortex. Elevated cortical MDD. These findings indicate that struggles secondary manifestations depression may independently contribute neurobiological changes.

Язык: Английский

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