Biochemical Pharmacology,
Год журнала:
2020,
Номер
180, С. 114175 - 114175
Опубликована: Июль 24, 2020
Eugenol,
a
common
phenylpropanoid
derivative
found
in
different
plant
species,
has
well-described
anti-inflammatory
effects
associated
with
the
development
of
occupational
hypersensitive
asthma.
Dehydrodieugenol,
dimeric
eugenol
derivative,
exhibits
and
antioxidant
activities
can
be
Brazilian
species
Nectandra
leucantha
(Lauraceae).
The
biological
dehydrodieugenol
on
lung
inflammation
remain
unclear.
This
study
aimed
to
investigate
isolated
from
N.
an
experimental
model
In
present
work,
toxic
RAW
264.7
cells
their
oxidant
inflammatory
before
lipopolysaccharide
(LPS)
exposure
were
tested.
Then,
male
BALB/c
mice
sensitized
ovalbumin
through
29-day
protocol
treated
vehicle,
eugenol,
or
dexamethasone
for
eight
days
beginning
22nd
day
until
end
protocol.
Lung
function;
profile;
protein
expression
ERK1/2,
JNK,
p38,
VAChT,
STAT3,
SOCS3
evaluated
by
immunoblotting.
Eugenol
nontoxic
cells.
Both
compounds
inhibited
NO
release
gene
IL-1β
IL-6
LPS-stimulated
OVA-sensitized
animals,
reduced
cell
numbers
concentrations
IL-4,
IL-13,
IL-17,
IL-10.
These
inhibition
p38
VAChT
STAT3/SOCS3
pathways.
Moreover,
treatment
effectively
attenuated
airway
hyperresponsiveness.
Conclusion:
obtained
data
demonstrate,
first
time,
that
was
more
effective
than
counteracting
allergic
mice,
especially
its
components
MAPK
pathway.
Therefore,
considered
prototype
new
agents
asthmatic
patients.
International Journal of Molecular Medicine,
Год журнала:
2017,
Номер
unknown
Опубликована: Ноя. 29, 2017
Flavonols
are
compounds
that
have
been
shown
to
possess
potent
anti‑inflammatory
effects
in
cellular
and
animal
models
of
inflammation.
In
the
present
study,
mechanisms
two
natural
flavonols,
quercetin
galangin,
lipopolysaccharide
(LPS)‑stimulated
RAW264.7
macrophages
were
investigated.
It
was
identified
galangin
markedly
reduced
production
nitric
oxide
(NO),
inducible
NO
synthase
interleukin‑6,
nuclear
translocation
factor‑κB
(NF‑κB).
addition,
LPS‑induced
activation
extracellular
signal‑regulated
kinase
1/2
(Erk1/2)
c‑Jun
N‑terminal
(JNK)
suppressed
by
galangin.
Taken
together,
these
data
implied
NF‑κB,
Erk1/2
JNK
may
be
potential
molecular
targets
an
inflammatory
response.
Subsequently,
oral
administration
or
either
alone
combination,
a
2,4‑dinitrochlorobenzene‑induced
atopic
dermatitis
(AD)
mouse
model
As
result,
measurements
ear
thickness
levels
serum
immunoglobulin
E,
histological
analysis
revealed
flavonols
led
decrease
inflammation,
whereas,
they
even
more
effective.
These
results
suggested
promising
therapeutic
agents
for
AD.
Additionally,
their
combination
novel
strategy
prevention
Oxidative Medicine and Cellular Longevity,
Год журнала:
2022,
Номер
2022, С. 1 - 12
Опубликована: Апрель 4, 2022
Oxidative
stress
is
defined
as
the
imbalance
between
reactive
oxygen
species
(ROS)
production
and
endogenous
antioxidant
defense
system,
leading
to
cellular
damage.
Asthma
a
common
chronic
inflammatory
airway
disease.
The
presence
of
asthma
tends
increase
(ROS),
system
in
lungs
insufficient
mitigate
it.
Therefore,
can
lead
an
exacerbation
hyperresponsiveness
inflammation.
PM2.5
exposure
increases
ROS
levels.
Meanwhile,
accumulation
will
further
enhance
oxidative
response,
resulting
DNA,
protein,
lipid,
other
molecular
damage,
respiratory
diseases.
An
in-depth
study
on
relationship
PM2.5-related
helpful
understand
pathogenesis
progression
disease
provides
new
direction
for
treatment
This
paper
reviews
research
progress
PM2.5-induced
well
highlights
therapeutic
potentials
approaches
asthma.
Journal of Thoracic Disease,
Год журнала:
2017,
Номер
9(1), С. E32 - E43
Опубликована: Янв. 1, 2017
Abstract:
Allergic
asthma
has
a
global
prevalence,
morbidity,
and
mortality.
Many
environmental
factors,
such
as
pollutants
allergens,
are
highly
relevant
to
allergic
asthma.
The
most
important
pathological
symptom
of
is
airway
inflammation.
Accordingly,
the
unique
role
reactive
oxygen
species
(ROS)
had
been
identified
main
reason
for
this
respiratory
studies
have
shown
that
inhalation
different
allergens
can
promote
ROS
generation.
Recent
demonstrated
several
pro-inflammatory
mediators
responsible
development
Among
these
mediators,
endogenous
or
exogenous
inflammation
Furthermore,
inflammatory
cells
induce
development.
Airway
inflammation,
hyper-responsiveness,
tissue
injury,
remodeling
be
induced
by
excessive
production
in
animal
models.
Based
on
investigations
formation
mechanisms,
we
novel
anti-inflammatory
therapeutic
treatments.
This
review
describes
recent
data
linking
pathogenesis
Phytotherapy Research,
Год журнала:
2023,
Номер
37(12), С. 5700 - 5723
Опубликована: Сен. 25, 2023
Abstract
Galangin
is
an
important
flavonoid
with
natural
activity,
that
abundant
in
galangal
and
propolis.
Currently,
various
biological
activities
of
galangin
have
been
disclosed,
including
anti‐inflammation,
antibacterial
effect,
anti‐oxidative
stress
aging,
anti‐fibrosis,
antihypertensive
effect.
Based
on
the
above
bioactivities,
more
attention
has
paid
to
role
neurodegenerative
diseases,
rheumatoid
arthritis,
osteoarthritis,
osteoporosis,
skin
cancer.
In
this
paper,
sources,
pharmacokinetics,
therapeutic
potential
against
diseases
were
systematically
reviewed
by
collecting
summarizing
relevant
literature.
addition,
molecular
mechanism
new
preparation
treatment
related
are
also
discussed,
broaden
application
prospect
provide
reference
for
its
clinical
application.
Furthermore,
it
should
be
noted
current
toxicity
studies
insufficient,
evidence
needed
support
possibility
as
a
functional
food.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2015,
Номер
2016(1)
Опубликована: Дек. 13, 2015
Asthma
is
one
of
the
most
common
inflammatory
diseases
characterized
by
airway
hyperresponsiveness,
inflammation,
and
remodeling.
Morin,
an
active
ingredient
obtained
from
Moraceae
plants,
has
been
demonstrated
to
have
promising
anti‐inflammatory
activities
in
a
range
disorders.
However,
its
impacts
on
pulmonary
diseases,
particularly
asthma,
not
clarified.
This
study
was
designed
investigate
whether
morin
alleviates
inflammation
chronic
asthma
with
emphasis
oxidative
stress
modulation.
In
vivo
,
ovalbumin‐
(OVA‐)
sensitized
mice
were
administered
or
dexamethasone
before
challenge.
Bronchoalveolar
lavage
fluid
(BALF)
lung
tissues
perform
cell
counts,
histological
analysis,
enzyme‐linked
immunosorbent
assay.
vitro
human
bronchial
epithelial
cells
(BECs)
challenged
tumor
necrosis
factor
alpha
(TNF‐
α
).
The
supernatant
collected
for
detection
proinflammatory
proteins,
reactive
oxygen
species
(ROS)/mitogen‐activated
protein
kinase
(MAPK)
evaluations.
Severe
responses
remodeling
observed
airways
OVA‐sensitized
mice.
Treatment
dramatically
attenuated
extensive
trafficking
into
BALF
inhibited
their
infiltration
around
respiratory
tracts
vessels.
Morin
administration
also
significantly
suppressed
goblet
hyperplasia
collagen
deposition/fibrosis
dose‐dependently
OVA‐induced
increases
IgE,
TNF‐
interleukin‐
(IL‐)
4,
IL‐13,
matrix
metalloproteinase‐9,
malondialdehyde.
BECs
levels
proteins
such
as
eotaxin‐1,
monocyte
chemoattractant
protein‐1,
IL‐8
intercellular
adhesion
molecule‐1,
consistently
decreased
morin.
Western
blotting
2′,7′‐dichlorofluorescein
assay
revealed
that
intracellular
ROS
MAPK
phosphorylation
abolished
morin,
implying
ROS/MAPK
signaling
contributes
relief
inflammation.
Our
findings
indicate
first
time
which
probably
occurs
via
stress‐responsive
pathway,
highlighting
novel
profile
potent
agent
management.
Evidence-based Complementary and Alternative Medicine,
Год журнала:
2020,
Номер
2020(1)
Опубликована: Янв. 1, 2020
Asthma,
a
disease
classified
as
chronic
inflammatory
disorder
induced
by
airway
inflammation,
is
triggered
genetic
predisposition
or
antigen
sensitization.
Drugs
currently
used
therapies
present
disadvantages
such
high
cost
and
side
effects,
which
compromise
the
treatment
compliance.
Alternatively,
traditional
medicine
has
reported
use
of
natural
products
alternative
complementary
treatment.
The
aim
this
review
was
to
summarize
knowledge
in
literature
about
for
asthma
search
strategy
included
scientific
studies
published
between
January
2006
December
2017,
using
keywords
"asthma,"
"treatment,"
"natural
products."
inclusion
criteria
were
follows:
(i)
that
aimed
at
elucidating
antiasthmatic
activity
natural-based
compounds
extracts
laboratory
experiments
(in
vitro
and/or
vivo);
(ii)
suggested
elucidation
its
chemical
composition.
Studies
did
not
report
experimental
data
manuscripts
languages
other
than
English
excluded.
Based
on
findings
from
search,
aspects
related
physiopathology,
epidemiology,
conventional
discussed.
Then,
several
reporting
effectiveness
presented,
highlighting
plants
main
source.
Moreover,
animals
microorganisms
also
discussed
their
potential
therapy
emphasized.
This
highlighted
importance
an
source
treatment,
since
they
reduced
effects
comparable
drugs
protocols.
