Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

Nature Medicine, Год журнала: 2017, Номер 23(7), С. 850 - 858

Опубликована: Май 22, 2017

Язык: Английский

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Blautia—a new functional genus with potential probiotic properties?

Gut Microbes, Год журнала: 2021, Номер 13(1)

Опубликована: Янв. 1, 2021

Blautia is a genus of anaerobic bacteria with probiotic characteristics that occur widely in the feces and intestines mammals. Based on phenotypic phylogenetic analyses, some species genera Clostridium Ruminococcus have been reclassified as Blautia, so to date, there are 20 new valid published names this genus. An extensive body research has recently focused effects genus, such biological transformation its ability regulate host health alleviate metabolic syndrome. This article reviews origin factors affect abundance discusses role health, thus laying theoretical foundation for development functional microorganisms properties.

Язык: Английский

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Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

Nature Medicine, Год журнала: 2018, Номер 24(12), С. 1919 - 1929

Опубликована: Окт. 26, 2018

Язык: Английский

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Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading Akkermansia muciniphila and Several Short-Chain Fatty Acid–Producing Microbiota in the Gut

Diabetes Care, Год журнала: 2016, Номер 40(1), С. 54 - 62

Опубликована: Ноя. 14, 2016

OBJECTIVE Recent studies suggest the beneficial effects of metformin on glucose metabolism may be microbially mediated. We examined association type 2 diabetes, metformin, and gut microbiota in community-dwelling Colombian adults. On basis previous research, we hypothesized that is associated with higher levels short-chain fatty acid (SCFA)–producing mucin-degrading microbiota. RESEARCH DESIGN AND METHODS Participants were selected from a larger cohort 459 participants. The present analyses focus 28 participants diagnosed diabetes—14 taking metformin— 84 without diabetes who matched (3-to-1) to by sex, age, BMI. measured demographic information, anthropometry, blood biochemical parameters collected fecal samples which performed 16S rRNA gene sequencing analyze composition structure RESULTS found an between was modified use. Compared had relative abundance Akkermansia muciniphila, known for mucin degradation, several production SCFAs, including Butyrivibrio, Bifidobacterium bifidum, Megasphaera, operational taxonomic unit Prevotella. In contrast, compared not Clostridiaceae 02d06 distinct Prevotella lower Enterococcus casseliflavus. CONCLUSIONS Our results support hypothesis shifts through enrichment A. muciniphila as well SCFA-producing Future are needed determine if these mediate metformin’s glycemic anti-inflammatory properties.

Язык: Английский

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Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

Nature Reviews Endocrinology, Год журнала: 2019, Номер 15(10), С. 569 - 589

Опубликована: Авг. 22, 2019

Язык: Английский

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Metformin and Its Benefits for Various Diseases

Frontiers in Endocrinology, Год журнала: 2020, Номер 11

Опубликована: Апрель 16, 2020

Metformin is a widely used biguanide drug due to its safety and low cost. It has been for over 60 years treat type 2 diabetes at the early stages because of outstanding ability decrease plasma glucose levels. Over time, different uses metformin were discovered, benefits various diseases even aging verified. These include cancers (e.g., breast cancer, endometrial bone colorectal melanoma), obesity, liver diseases, cardiovascular disease, renal diseases. exerts effects through signaling pathways. However, underlying mechanisms these remain be elucidated. The aim this review provide brief summary discuss possible mechanisms.

Язык: Английский

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The quest to slow ageing through drug discovery

Nature Reviews Drug Discovery, Год журнала: 2020, Номер 19(8), С. 513 - 532

Опубликована: Май 28, 2020

Язык: Английский

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Gut microbiome and type 2 diabetes: where we are and where to go?

The Journal of Nutritional Biochemistry, Год журнала: 2018, Номер 63, С. 101 - 108

Опубликована: Окт. 11, 2018

Язык: Английский

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Biological properties and clinical applications of berberine

Frontiers of Medicine, Год журнала: 2020, Номер 14(5), С. 564 - 582

Опубликована: Апрель 25, 2020

Язык: Английский

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Structural Alteration of Gut Microbiota during the Amelioration of Human Type 2 Diabetes with Hyperlipidemia by Metformin and a Traditional Chinese Herbal Formula: a Multicenter, Randomized, Open Label Clinical Trial

mBio, Год журнала: 2018, Номер 9(3)

Опубликована: Май 21, 2018

ABSTRACT Accumulating evidence implicates gut microbiota as promising targets for the treatment of type 2 diabetes mellitus (T2DM). With a randomized clinical trial, we tested hypothesis that alteration may be involved in alleviation T2DM with hyperlipidemia by metformin and specifically designed herbal formula (AMC). Four hundred fifty patients were randomly assigned to either metformin- or AMC-treated group. After 12 weeks treatment, 100 selected from each group assessed improvement. The effects two drugs on intestinal evaluated analyzing V3 V4 regions 16S rRNA gene Illumina sequencing multivariate statistical methods. Both AMC significantly alleviated hyperglycemia shifted structure diabetic patients. They increased coabundant represented Blautia spp., which correlated improvements glucose lipid homeostasis. However, showed better efficacies improving homeostasis model assessment insulin resistance (HOMA-IR) plasma triglyceride also exerted larger effect microbiota. Furthermore, only Faecalibacterium was previously reported associated trial. Metformin Chinese ameliorate via enriching beneficial bacteria, such spp. IMPORTANCE Metabolic diseases obesity have become worldwide public health threat. indicates can causatively arouse metabolic diseases, thus serves target disease control. In this study, role during drugs: (AMC) hyperlipidemia. ameliorated blood levels identified being both drugs. together HOMA-IR levels, enrichment brief, these data suggest might formula.

Язык: Английский

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