Drosophila Gr64e mediates fatty acid sensing via the phospholipase C pathway DOI Creative Commons
Hyeyon Kim,

Haein Kim,

Jae Young Kwon

и другие.

PLoS Genetics, Год журнала: 2018, Номер 14(2), С. e1007229 - e1007229

Опубликована: Фев. 8, 2018

Animals use taste to sample and ingest essential nutrients for survival. Free fatty acids (FAs) are energy-rich that contribute various cellular functions. Recent evidence suggests FAs detected through the gustatory system promote feeding. In Drosophila, phospholipase C (PLC) signaling in sweet-sensing cells is required FA detection but other molecules unknown. Here, we show Gr64e behavioral electrophysiological responses FAs. GR64e TRPA1 interchangeable when they act downstream of PLC: can substitute not glycerol sensing, aristolochic acid N-methylmaleimide sensing. contrast its role functions as a ligand-gated ion channel detection. Our results identify novel transduction molecule reveal Drosophila Grs via distinct molecular mechanisms depending on context.

Язык: Английский

Diverse Food-Sensing Neurons Trigger Idiothetic Local Search in Drosophila DOI Creative Commons
Román A. Corfas, Tarun Kumar Sharma, Michael H. Dickinson

и другие.

Current Biology, Год журнала: 2019, Номер 29(10), С. 1660 - 1668.e4

Опубликована: Май 1, 2019

Язык: Английский

Процитировано

66
Genome-wide analysis of ionotropic receptor gene repertoire in Lepidoptera with an emphasis on its functions of Helicoverpa armigera DOI
Nai‐Yong Liu, Wei Xu,

Shuang-Lin Dong

и другие.

Insect Biochemistry and Molecular Biology, Год журнала: 2018, Номер 99, С. 37 - 53

Опубликована: Май 22, 2018

Язык: Английский

Процитировано

62
Drosophila gustatory projections are segregated by taste modality and connectivity DOI Creative Commons
Stefanie Engert, Gabriella R Sterne, Davi D. Bock

и другие.

eLife, Год журнала: 2022, Номер 11

Опубликована: Май 25, 2022

Gustatory sensory neurons detect caloric and harmful compounds in potential food convey this information to the brain inform feeding decisions. To examine signals that gustatory transmit receive, we reconstructed axons their synaptic sites adult

Язык: Английский

Процитировано

31
More than meets the IR: the expanding roles of variant Ionotropic Glutamate Receptors in sensing odor, taste, temperature and moisture DOI Creative Commons
Lena van Giesen, Paul Garrity

F1000Research, Год журнала: 2017, Номер 6, С. 1753 - 1753

Опубликована: Сен. 26, 2017

The ionotropic receptors (IRs) are a branch of the glutamate receptor family and serve as important mediators sensory transduction in invertebrates. Recent work shows that, though initially studied olfactory receptors, IRs also mediate detection taste, temperature, humidity. Here, we summarize recent insights into IR evolution its potential ecological significance well advances our understanding how contribute to diverse modalities.

Язык: Английский

Процитировано

60
Drosophila Gr64e mediates fatty acid sensing via the phospholipase C pathway DOI Creative Commons
Hyeyon Kim,

Haein Kim,

Jae Young Kwon

и другие.

PLoS Genetics, Год журнала: 2018, Номер 14(2), С. e1007229 - e1007229

Опубликована: Фев. 8, 2018

Animals use taste to sample and ingest essential nutrients for survival. Free fatty acids (FAs) are energy-rich that contribute various cellular functions. Recent evidence suggests FAs detected through the gustatory system promote feeding. In Drosophila, phospholipase C (PLC) signaling in sweet-sensing cells is required FA detection but other molecules unknown. Here, we show Gr64e behavioral electrophysiological responses FAs. GR64e TRPA1 interchangeable when they act downstream of PLC: can substitute not glycerol sensing, aristolochic acid N-methylmaleimide sensing. contrast its role functions as a ligand-gated ion channel detection. Our results identify novel transduction molecule reveal Drosophila Grs via distinct molecular mechanisms depending on context.

Язык: Английский

Процитировано

57