Marine natural products

Natural Product Reports, Год журнала: 2018, Номер 35(1), С. 8 - 53

Опубликована: Янв. 1, 2018

This review of 2016 literature describes the structures and biological activities 1277 new marine natural products structure revision absolute configuration previously reported MNPs. The chemical diversity 28 609 MNPs since 1957 is also investigated compared to that approved drugs.

Язык: Английский

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An overview of natural antimicrobials role in food

European Journal of Medicinal Chemistry, Год журнала: 2017, Номер 143, С. 922 - 935

Опубликована: Дек. 2, 2017

Язык: Английский

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Marine natural products

Natural Product Reports, Год журнала: 2017, Номер 34(3), С. 235 - 294

Опубликована: Янв. 1, 2017

Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382-431This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 period January to December 2015) referring compounds isolated from microorganisms and phytoplankton, green, brown red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves other intertidal plants microorganisms. The emphasis is on new (1340 429 papers 2015), together relevant biological activities, source organisms country of origin. Reviews, biosynthetic studies, first syntheses, syntheses that lead revision structures or stereochemistries, have been included.

Язык: Английский

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Bioactivity Screening of Microalgae for Antioxidant, Anti-Inflammatory, Anticancer, Anti-Diabetes, and Antibacterial Activities

Frontiers in Marine Science, Год журнала: 2016, Номер 3

Опубликована: Май 10, 2016

Marine microalgae are considered a potentially new and valuable source of biologically active molecules for applications in the food industry as well pharmaceutical, nutraceutical cosmetic sectors. They can be easily cultured, have short generation times enable an environmentally-friendly approach to drug discovery by overcoming problems associated with over-utilization marine resources use destructive collection practices. In this study, 21 diatoms, 7 dinoflagellates 4 flagellate species were grown three different culturing conditions corresponding extracts tested possible antioxidant, anti-inflammatory, anticancer, anti-diabetes, antibacterial anti-biofilm activities. addition, two diatoms we also clones disclose diversity clone bioactivity. Six diatom displayed specific anticancer (blocking human melanoma cell proliferation) (against bacteria Staphylococcus epidermidis) activities whereas, none other bioactive against for. Furthermore, 6 toxic on normal cells. Culturing (i.e. nutrient starvation conditions) greatly influenced bioactivity majority clones/species tested. This study denotes potential sources promising bioactives treatment pathologies.

Язык: Английский

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Antibacterial Derivatives of Marine Algae: An Overview of Pharmacological Mechanisms and Applications

Marine Drugs, Год журнала: 2016, Номер 14(4), С. 81 - 81

Опубликована: Апрель 22, 2016

The marine environment is home to a taxonomically diverse ecosystem. Organisms such as algae, molluscs, sponges, corals, and tunicates have evolved survive the high concentrations of infectious surface-fouling bacteria that are indigenous ocean waters. Both macroalgae (seaweeds) microalgae (diatoms) contain pharmacologically active compounds phlorotannins, fatty acids, polysaccharides, peptides, terpenes which combat bacterial invasion. resistance pathogenic existing antibiotics has become global epidemic. Marine algae derivatives shown promise candidates in novel, antibacterial drug discovery. efficacy these compounds, their mechanism action, applications antibiotics, disinfectants, inhibitors foodborne spoilage reviewed this article.

Язык: Английский

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Quorum sensing inhibitors as antipathogens: biotechnological applications

Biotechnology Advances, Год журнала: 2018, Номер 37(1), С. 68 - 90

Опубликована: Ноя. 22, 2018

Язык: Английский

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Biological Activity of Recently Discovered Halogenated Marine Natural Products

Marine Drugs, Год журнала: 2015, Номер 13(7), С. 4044 - 4136

Опубликована: Июнь 30, 2015

This review presents the biological activity—antibacterial, antifungal, anti-parasitic, antiviral, antitumor, antiinflammatory, antioxidant, and enzymatic activity—of halogenated marine natural products discovered in past five years. Newly examples that do not report activity are included.

Язык: Английский

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Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review

Frontiers in Microbiology, Год журнала: 2019, Номер 10

Опубликована: Фев. 26, 2019

Microbial secondary metabolites (MSMs) have played and continue to play a highly significant role in the drug discovery development process. Genetically, MSM chemical structures are biologically synthesized by microbial gene clusters. Recently, however, speed of new bioactive has been slowing down due consistent employment conventional cultivation isolation procedure. In order alleviate this challenge, number approaches developed. The strategy one strain many compounds (OSMAC) shown as simple powerful tool that can activate silent biogenetic clusters microorganisms make more natural products. This review highlights important successful examples using OSMAC approaches, which covers changing medium composition status, co-cultivation with other strain(s), adding enzyme inhibitor(s) biosynthetic precursor(s). Available evidences had variation condition is most effective way produce MSMs facilitate therapeutic agents.

Язык: Английский

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Prospects and challenges for industrial production of seaweed bioactives

Journal of Phycology, Год журнала: 2015, Номер 51(5), С. 821 - 837

Опубликована: Июль 23, 2015

Large‐scale seaweed cultivation has been instrumental in globalizing the industry since 1950s. The domestication of cultivars (begun 1940s) ended reliance on natural cycles raw material availability for some species, with efforts driven by consumer demands that far exceeded available supplies. Currently, is unrivaled mariculture 94% annual biomass utilized globally being derived from cultivated sources. In last decade, research confirmed seaweeds as rich sources potentially valuable, health‐promoting compounds. Most existing and current techniques have developed producing commoditized biomass, may not necessarily be optimized production valuable bioactive future will include development high value markets functional foods, cosmeceuticals, nutraceuticals, pharmaceuticals. Entry into these require a level standardization, efficacy, traceability previously demanded products. Both internal concentrations composition compounds can fluctuate seasonally, geographically, bathymetrically, according to genetic variability even within individual especially where life history stages important. History shows successful expansion products new requires domesticated cultivars. Demands an evolving based upon efficacy standardization selection improved cultivars, refinement improve quality control

Язык: Английский

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Strategies to diversify natural products for drug discovery

Medicinal Research Reviews, Год журнала: 2017, Номер 38(4), С. 1255 - 1294

Опубликована: Окт. 24, 2017

Natural product libraries contain specialized metabolites derived from plants, animals, and microorganisms that play a pivotal role in drug discovery due to their immense structural diversity wide variety of biological activities. The strategies greatly extend natural scaffolds through available chemical approaches offer unique opportunities access new series analogues, enabling the construction diverse product-like libraries. affordability these structurally molecules has been crucial step accelerating discovery. This review provides an overview various exploit compounds for product-based development, drawing upon examples illustrate each strategy.

Язык: Английский

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