Marine Drugs,
Год журнала:
2018,
Номер
16(8), С. 279 - 279
Опубликована: Авг. 14, 2018
The
increase
of
many
deadly
diseases
like
infections
by
multidrug-resistant
bacteria
implies
re-inventing
the
wheel
on
drug
discovery.
A
better
comprehension
metabolisms
and
regulation
diseases,
in
knowledge
based
study
disease-born
microorganisms’
genomes,
development
more
representative
disease
models
improvement
techniques,
technologies,
computation
applied
to
biology
are
advances
that
will
foster
discovery
upcoming
years.
In
this
paper,
several
aspects
current
methodologies
for
antibacterial
antifungals,
anti-tropical
antibiofilm
antiquorum
sensing,
anticancer
neuroprotectors
considered.
For
discovery,
two
different
complementary
approaches
can
be
applied:
classical
pharmacology,
also
known
as
phenotypic
which
is
historical
basis
reverse
designated
target-based
Screening
methods
have
been
used
discover
new
natural
products
mainly
from
terrestrial
origin.
Examples
marine
provided.
section
future
trends
provides
a
comprehensive
overview
recent
pharmaceutical
industry.
International Journal of Molecular Sciences,
Год журнала:
2018,
Номер
19(6), С. 1578 - 1578
Опубликована: Май 25, 2018
The
therapeutic
properties
of
plants
have
been
recognised
since
time
immemorial.
Many
pathological
conditions
treated
using
plant-derived
medicines.
These
medicines
are
used
as
concoctions
or
concentrated
plant
extracts
without
isolation
active
compounds.
Modern
medicine
however,
requires
the
and
purification
one
two
There
however
a
lot
global
health
challenges
with
diseases
such
cancer,
degenerative
diseases,
HIV/AIDS
diabetes,
which
modern
is
struggling
to
provide
cures.
times
"active
compound"
has
made
compound
ineffective.
Drug
discovery
multidimensional
problem
requiring
several
parameters
both
natural
synthetic
compounds
safety,
pharmacokinetics
efficacy
be
evaluated
during
drug
candidate
selection.
advent
latest
technologies
that
enhance
design
hypotheses
Artificial
Intelligence,
use
'organ-on
chip'
microfluidics
technologies,
means
automation
become
part
discovery.
This
resulted
in
increased
speed
evaluation
whilst
allowing
novel
ways
synthesis
based
on
Recent
advances
analytical
computational
techniques
opened
new
avenues
process
complex
products
their
structures
derive
innovative
drugs.
Indeed,
we
era
molecular
design,
applied
products.
Predictive
softwares
contributed
targets
derivatives.
In
future
quantum
computing,
databases
modelling
interactions
predicting
features
needed
for
development,
pharmacokinetic
pharmacodynamics,
will
result
few
false
positive
leads
development.
review
discusses
plant-based
product
how
play
role
next-generation
Journal of Cheminformatics,
Год журнала:
2020,
Номер
12(1)
Опубликована: Апрель 3, 2020
Abstract
Natural
products
(NPs)
have
been
the
centre
of
attention
scientific
community
in
last
decencies
and
interest
around
them
continues
to
grow
incessantly.
As
a
consequence,
20
years,
there
was
rapid
multiplication
various
databases
collections
as
generalistic
or
thematic
resources
for
NP
information.
In
this
review,
we
establish
complete
overview
these
resources,
numbers
are
overwhelming:
over
120
different
were
published
re-used
since
2000.
98
still
somehow
accessible
only
50
open
access.
The
latter
include
not
but
also
big
NPs
supplementary
material
publications
that
backed
up
ZINC
database
commercially-available
compounds.
Some
databases,
even
relatively
recently
already
anymore,
which
leads
dramatic
loss
data
on
NPs.
sources
presented
manuscript,
together
with
comparison
content
ones.
With
compiled
open-access
natural
compounds
one
single
dataset
COlleCtion
Open
NatUral
producTs
(COCONUT),
is
available
Zenodo
contains
structures
sparse
annotations
400,000
non-redundant
NPs,
makes
it
biggest
collection
date.
Natural Product Reports,
Год журнала:
2021,
Номер
38(2), С. 362 - 413
Опубликована: Янв. 1, 2021
This
review
covers
the
literature
published
in
2019
for
marine
natural
products
(MNPs),
with
719
citations
(701
period
January
to
December
2019)
referring
compounds
isolated
from
microorganisms
and
phytoplankton,
green,
brown
red
algae,
sponges,
cnidarians,
bryozoans,
molluscs,
tunicates,
echinoderms,
mangroves
other
intertidal
plants
microorganisms.
The
emphasis
is
on
new
(1490
440
papers
2019),
together
relevant
biological
activities,
source
organisms
country
of
origin.
Pertinent
reviews,
biosynthetic
studies,
first
syntheses,
syntheses
that
led
revision
structures
or
stereochemistries,
have
been
included.
Methods
used
study
fungi
their
chemical
diversity
also
discussed.
ACS Medicinal Chemistry Letters,
Год журнала:
2018,
Номер
9(10), С. 959 - 961
Опубликована: Сен. 13, 2018
An
overview
of
the
marine
natural
products
(MNPs)
field
is
shown,
including
an
update
FDA-approved
drugs
and
those
in
clinical
trials
that
can
be
considered
derivatives
MNPs.
The
importance
microorganisms
present
studies
application
emerging
techniques
technologies
to
this
are
highlighted.
Water Research,
Год журнала:
2021,
Номер
196, С. 117017 - 117017
Опубликована: Март 8, 2021
Harmful
cyanobacterial
blooms,
which
frequently
contain
toxic
secondary
metabolites,
are
reported
in
aquatic
environments
around
the
world.
More
than
two
thousand
metabolites
have
been
from
diverse
sources
over
past
fifty
years.
A
comprehensive,
publically-accessible
database
detailing
these
would
facilitate
research
into
their
occurrence,
functions
and
toxicological
risks.
To
address
this
need
we
created
CyanoMetDB,
a
highly
curated,
flat-file,
openly-accessible
of
collated
850
peer-reviewed
articles
published
between
1967
2020.
CyanoMetDB
contains
2010
99
structurally
related
compounds.
This
has
nearly
doubled
number
entries
with
complete
literature
metadata
structural
composition
information
compared
to
previously
available
open
access
databases.
The
dataset
includes
microcytsins,
cyanopeptolins,
other
depsipeptides,
anabaenopeptins,
microginins,
aeruginosins,
cyclamides,
cryptophycins,
saxitoxins,
spumigins,
microviridins,
anatoxins
among
metabolite
classes.
comprehensive
dedicated
facilitates:
(1)
detection
dereplication
known
toxins
metabolites;
(2)
identification
novel
natural
products
cyanobacteria;
(3)
on
biosynthesis
including
substructure
searches;
(4)
investigation
abundance,
persistence,
toxicity
environments.
Molecules,
Год журнала:
2019,
Номер
24(22), С. 4182 - 4182
Опубликована: Ноя. 18, 2019
Seaweeds
have
received
huge
interest
in
recent
years
given
their
promising
potentialities.
Their
antioxidant,
anti-inflammatory,
antitumor,
hypolipemic,
and
anticoagulant
effects
are
among
the
most
renowned
studied
bioactivities
so
far,
these
been
increasingly
associated
with
content
richness
both
primary
secondary
metabolites.
Although
metabolites
a
pivotal
importance
such
as
polysaccharides
(fucoidans,
agars,
carragenans,
ulvans,
alginates,
laminarin),
data
shown
that
some
largely
determines
effective
bioactive
potential
of
seaweeds.
Among
metabolites,
phenolic
compounds
feature
prominently.
The
present
review
provides
remarkable
insights
into
seaweed
research,
specifically
addressing
its
chemical
composition,
phytopharmacology,
cosmetic
applications.
Frontiers in Pharmacology,
Год журнала:
2018,
Номер
9
Опубликована: Авг. 6, 2018
Marine
environment
has
demonstrated
to
be
an
interesting
source
of
compounds
with
uncommon
and
unique
chemical
features
on
which
the
molecular
modelling
synthesis
new
drugs
can
based
greater
efficacy
specificity
for
therapeutics.
Cancer
is
a
growing
public
health
threat,
despite
advances
in
biomedical
research
technology,
there
urgent
need
development
anticancer
drugs.
In
this
field,
it
estimated
that
more
than
60%
commercially
available
are
natural
biomimetic
inspired.
Among
marine
organisms,
algae
have
been
revealed
one
major
sources
origin,
including
those
exhibiting
antitumour
cytotoxic
potential
by
mediating
specific
inhibitory
activities
number
key
cellular
processes,
apoptosis
pathways,
angiogenesis,
migration
invasion
both
vitro
vivo
models,
revealing
their
used
as
anti-cancer
This
review
will
focus
bioactive
molecules
from
potential,
origin
uses,
special
emphasis
Sphaerococcus
coronopifolius
producer
compounds.
