Journal of the American Chemical Society,
Год журнала:
2021,
Номер
143(49), С. 20818 - 20827
Опубликована: Дек. 6, 2021
Multicomponent
reactions
that
involve
interception
of
onium
ylides
through
Aldol,
Mannich,
and
Michael
addition
with
corresponding
bench-stable
acceptors
have
demonstrated
broad
applications
in
synthetic
chemistry.
However,
because
the
high
reactivity
transient
survival
these
situ
generated
intermediates,
substitution-type
process,
especially
asymmetric
catalytic
version,
remains
hitherto
unknown.
Herein,
a
three-component
allylation
α-diazo
carbonyl
compounds
alcohols
allyl
carbonates
is
disclosed
by
employing
ternary
cooperative
catalysis
achiral
Pd-complex,
Rh2(OAc)4,
chiral
phosphoric
acid
CPA.
This
method
represents
first
example
allylic
alkylation
an
SN1-type
trapping
which
involves
convergent
assembly
two
active
Pd-allyl
species,
enol
derived
from
ylides,
providing
expeditious
access
to
α,α-disubstituted
ketones
good
yields
excellent
enantioselectivity.
Combined
experimental
computational
studies
shed
light
on
mechanism
this
novel
reaction,
including
critical
role
Xantphos
ligand
origin
Chemical Reviews,
Год журнала:
2018,
Номер
119(4), С. 2192 - 2452
Опубликована: Ноя. 27, 2018
C–H
activation
has
surfaced
as
an
increasingly
powerful
tool
for
molecular
sciences,
with
notable
applications
to
material
crop
protection,
drug
discovery,
and
pharmaceutical
industries,
among
others.
Despite
major
advances,
the
vast
majority
of
these
functionalizations
required
precious
4d
or
5d
transition
metal
catalysts.
Given
cost-effective
sustainable
nature
earth-abundant
first
row
metals,
development
less
toxic,
inexpensive
3d
catalysts
gained
considerable
recent
momentum
a
significantly
more
environmentally-benign
economically-attractive
alternative.
Herein,
we
provide
comprehensive
overview
on
until
summer
2018.
Chemical Society Reviews,
Год журнала:
2018,
Номер
47(15), С. 5786 - 5865
Опубликована: Янв. 1, 2018
This
review
provides
an
overview
of
the
use
electrochemistry
as
appealing
platform
for
expediting
carbon–hydrogen
functionalization
and
carbon–nitrogen
bond
formation.
Angewandte Chemie International Edition,
Год журнала:
2019,
Номер
58(37), С. 12803 - 12818
Опубликована: Май 11, 2019
Molecular
syntheses
largely
rely
on
time-
and
labour-intensive
prefunctionalization
strategies.
In
contrast,
C-H
activation
represents
an
increasingly
powerful
approach
that
avoids
lengthy
of
prefunctionalized
substrates,
with
great
potential
for
drug
discovery,
the
pharmaceutical
industry,
material
sciences,
crop
protection,
among
others.
The
enantioselective
functionalization
omnipresent
bonds
has
emerged
as
a
transformative
tool
step-
atom-economical
generation
chiral
molecular
complexity.
However,
this
rapidly
growing
research
area
remains
dominated
by
noble
transition
metals,
prominently
featuring
toxic
palladium,
iridium
rhodium
catalysts.
Indeed,
despite
significant
achievements,
use
inexpensive
sustainable
3d
metals
in
asymmetric
activations
is
still
clearly
its
infancy.
Herein,
we
discuss
remarkable
recent
progress
transformations
via
organometallic
base
up
to
April
2019.
Angewandte Chemie International Edition,
Год журнала:
2018,
Номер
57(42), С. 13735 - 13747
Опубликована: Июнь 6, 2018
Functionalized
cyclic
organic
carbonates
and
related
heterocycles
have
emerged
as
highly
versatile
heterocyclic
substrates
for
ring-opening
decarboxylative
catalytic
transformations
allowing
the
development
of
new
stereo-
enantioselective
C-N,
C-O,
C-C,
C-S
C-B
bond
formation
reactions.
Transition-metal-mediated
conversions
only
recently
been
rejuvenated
powerful
approaches
towards
preparation
more
complex
molecules.
This
minireview
will
highlight
potential
structurally
with
a
focus
on
their
synthetic
value
mechanistic
manifolds
that
are
involved
upon
conversion.
Chemical Reviews,
Год журнала:
2020,
Номер
120(24), С. 13382 - 13433
Опубликована: Ноя. 29, 2020
Synergistic
catalysis,
a
type
of
plural
catalysis
which
utilizes
at
least
two
different
catalysts
to
enable
reaction
between
separately
activated
substrates,
has
unlocked
plethora
previously
unattainable
transformations
and
novel
chemical
reactivity.
Despite
the
appreciable
utility
synergistic
specific
examples
involving
transition
metals
have
been
limited,
as
ensuring
judicious
choice
parameters
prevent
deactivation
catalysts,
undesirable
monocatalytic
event(s)
leading
side
products,
or
premature
termination
other
potentially
troublesome
outcomes
present
formidable
challenge.
Excluding
those
driven
by
photocatalytic
mechanisms,
this
review
will
highlight
reported
reactions
that
make
use
simultaneous
catalytic
cycles
metal
catalysts.
Angewandte Chemie International Edition,
Год журнала:
2018,
Номер
57(47), С. 15425 - 15429
Опубликована: Окт. 6, 2018
The
enantioselective
cobalt(III)-catalyzed
C-H
alkylation
was
achieved
through
the
design
of
a
novel
chiral
acid.
activation
characterized
by
high
position-,
regio-
and
enantio-control
under
exceedingly
mild
reaction
conditions.
Thereby,
robust
cooperative
cobalt(III)
catalysis
proved
tolerant
valuable
electrophilic
functional
groups,
including
hydroxyl,
bromo,
iodo
substituents.
Mechanistic
studies
revealed
considerable
additive
effect
on
kinetics
negative
non-linear-effect.
Chemical Society Reviews,
Год журнала:
2020,
Номер
50(2), С. 1391 - 1406
Опубликована: Дек. 10, 2020
One-pot
reactions
based
on
catalytic
isomerization
of
alkenes
not
only
offer
the
inherent
advantages
atom-,
step-
and
redox-economy
but
also
enable
preparation
value-added
products
that
would
be
difficult
to
access
by
conventional
methods.
Organic Chemistry Frontiers,
Год журнала:
2021,
Номер
8(15), С. 4315 - 4348
Опубликована: Янв. 1, 2021
Catalytic
asymmetric
MCCRs
for
enantioselective
synthesis
of
spirooxindoles
by
using
chiral
phosphoric
acids,
amines,
bifunctional
thiourea/squaramides
and
metal-based
reagents
as
catalysts.
