From fundamentals to applications: a toolbox for robust and multifunctional MOF materials

Chemical Society Reviews, Год журнала: 2018, Номер 47(23), С. 8611 - 8638

Опубликована: Янв. 1, 2018

In recent years, metal-organic frameworks (MOFs) have been regarded as one of the most important classes materials. The combination various metal clusters and ligands, arranged in a vast array geometries has led to an ever-expanding MOF family. Each year, new novel structures are discovered. structural diversity present MOFs significantly expanded application these show great potential for variety applications, including but not limited to: gas storage separation, catalysis, biomedicine delivery, chemical sensing. This review intends offer short summary some topics development MOFs. scope this shall cover fundamental aspects concerning design synthesis range practical applications regarding their stability derivative structures. Emerging trends will also be discussed. These include multicomponent MOFs, defect composites. ever structure-property-application relationship investigated. Overall, provides insight into both existing emerging

Язык: Английский

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Controllable design of tunable nanostructures inside metal–organic frameworks

Chemical Society Reviews, Год журнала: 2017, Номер 46(15), С. 4614 - 4630

Опубликована: Янв. 1, 2017

This review focuses on recent progress in the design of tunable nanoentities encapsulated by metal–organic frameworks (MOFs), with special emphasis preparation and synergistic properties such composites.

Язык: Английский

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Metal–Organic Framework-Based Enzyme Biocomposites

Chemical Reviews, Год журнала: 2021, Номер 121(3), С. 1077 - 1129

Опубликована: Янв. 13, 2021

Because of their efficiency, selectivity, and environmental sustainability, there are significant opportunities for enzymes in chemical synthesis biotechnology. However, as the three-dimensional active structure is predominantly maintained by weaker noncovalent interactions, thermal, pH, stressors can modify or eliminate activity. Metal–organic frameworks (MOFs), which extended porous network materials assembled a bottom-up building block approach from metal-based nodes organic linkers, be used to afford protection enzymes. The self-assembled structures MOFs encase an enzyme process called encapsulation when MOF synthesized presence biomolecule. Alternatively, infiltrated into mesoporous surface bound via covalent processes. Integration this way affords allows maintain activity challenge conditions (e.g., denaturing agents, elevated temperature, non-native solvents). In addition forming simple enzyme/MOF biocomposites, other introduced composites improve recovery facilitate advanced applications sensing fuel cell technology. This review canvasses encapsulation, pore infiltration, adsorption summarizes strategies form multicomponent composites. Also, given that biocomposites straddle chemistry enzymology, provides assessment characterization methodologies MOF-immobilized identifies some key parameters development field.

Язык: Английский

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Tackling the Challenges of Enzymatic (Bio)Fuel Cells

Chemical Reviews, Год журнала: 2019, Номер 119(16), С. 9509 - 9558

Опубликована: Июнь 25, 2019

The ever-increasing demands for clean and sustainable energy sources combined with rapid advances in biointegrated portable or implantable electronic devices have stimulated intensive research activities enzymatic (bio)fuel cells (EFCs). use of renewable biocatalysts, the utilization abundant green, safe, high density fuels, together capability working at modest biocompatible conditions make EFCs promising as next generation alternative power sources. However, main challenges (low density, relatively low poor operational stability, limited voltage output) hinder future applications EFCs. This review aims exploring underlying mechanism providing possible practical strategies, methodologies insights to tackle these issues. First, this summarizes approaches achieving densities EFCs, particularly, employing enzyme cascades deep/complete oxidation fuels. Second, strategies increasing including activities, facilitating electron transfers, nanomaterials, designing more efficient enzyme-electrode interfaces, are described. potential EFCs/(super)capacitor combination is discussed. Third, evaluates a range improving stability different immobilization approaches, tuning properties, protective matrixes, using microbial surface displaying enzymes. Fourth, improvement cell highlighted. Finally, developments prospective on envisioned.

Язык: Английский

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Acid-Resistant Mesoporous Metal–Organic Framework toward Oral Insulin Delivery: Protein Encapsulation, Protection, and Release

Journal of the American Chemical Society, Год журнала: 2018, Номер 140(17), С. 5678 - 5681

Опубликована: Апрель 11, 2018

Diabetes affects millions of people worldwide and the number diagnoses continues to climb annually. Though several effective medications therapeutic methods have been developed treat type 1 (T1DM) 2 (T2DM) diabetes mellitus, direct insulin injection remains only treatment for resistant (IR) patients. Here, we immobilize in a crystalline mesoporous metal-organic framework (MOF), NU-1000, obtain high loading ∼40 wt % 30 min. The acid-stable MOF capsules are found effectively prevent from degrading presence stomach acid digestive enzyme, pepsin. Furthermore, encapsulated can be released NU-1000 under simulated physiological conditions.

Язык: Английский

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Green synthesis of metal–organic frameworks: A state-of-the-art review of potential environmental and medical applications

Coordination Chemistry Reviews, Год журнала: 2020, Номер 420, С. 213407 - 213407

Опубликована: Июнь 9, 2020

Язык: Английский

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Erythrocyte Membrane Cloaked Metal–Organic Framework Nanoparticle as Biomimetic Nanoreactor for Starvation-Activated Colon Cancer Therapy

ACS Nano, Год журнала: 2018, Номер 12(10), С. 10201 - 10211

Опубликована: Сен. 28, 2018

Shutting down glucose supply by oxidase (GOx) to starve tumors has been considered be an attractive strategy in cancerous starvation therapy. Nevertheless, the vivo applications of GOx-based therapy are severely restricted poor GOx delivery efficiency and self-limiting therapeutic effect. Herein, a biomimetic nanoreactor fabricated for starvation-activated cancer encapsulating prodrug tirapazamine (TPZ) erythrocyte membrane cloaked metal-organic framework (MOF) nanoparticle (TGZ@eM). The TGZ@eM can assist tumor cells then exhaust endogenous O2 efficiently. Importantly, resulting hypoxia further initiates activation TPZ, which is released from acid lyso/endosome environment, enhanced colon More importantly, integrating surface modification, immunity-escaping prolonged blood circulation characteristics endow our dramatically improved targeting ability. vitro outcomes indicate exhibits strong synergistic cascade effect accurate facile manner.

Язык: Английский

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Pore Environment Control and Enhanced Performance of Enzymes Infiltrated in Covalent Organic Frameworks

Journal of the American Chemical Society, Год журнала: 2017, Номер 140(3), С. 984 - 992

Опубликована: Дек. 25, 2017

In the drive toward green and sustainable methodologies for chemicals manufacturing, biocatalysts are predicted to have much offer in years come. That being said, their practical applications often hampered by a lack of long-term operational stability, limited operating range, low recyclability enzymes utilized. Herein, we show how covalent organic frameworks (COFs) possess all necessary requirements needed serve as ideal host materials enzymes. The resultant biocomposites this study shown ability boost stability robustness enzyme question, namely lipase PS, while also displaying activities far outperforming free made from other types porous materials, such mesoporous silica metal-organic frameworks, exemplified kinetic resolution alcohol assays performed. easily tune pore environment COF using monomers bearing specific functional groups can improve its compatibility with given enzyme. As result, orientation active site be modulated through designed interactions between both components, thus improving enzymatic activity biocomposites. Moreover, comparison amorphous analogues, well-defined channels not only make accommodated more accessible reagents but stronger shields safeguard deactivation, evidenced superior tolerance harsh environments. amenability COFs, along our increasing understanding design rules stabilizing an fashion, gives great promise providing "off shelf" synthetic transformations.

Язык: Английский

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Metal-organic frameworks as novel matrices for efficient enzyme immobilization: An update review

Coordination Chemistry Reviews, Год журнала: 2019, Номер 406, С. 213149 - 213149

Опубликована: Дек. 20, 2019

Язык: Английский

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Hierarchically Engineered Mesoporous Metal-Organic Frameworks toward Cell-free Immobilized Enzyme Systems

Chem, Год журнала: 2018, Номер 4(5), С. 1022 - 1034

Опубликована: Март 29, 2018

Язык: Английский

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