Materials,
Год журнала:
2018,
Номер
11(2), С. 187 - 187
Опубликована: Янв. 24, 2018
Flexible
hybrid
electronics
(FHE),
designed
in
wearable
and
implantable
configurations,
have
enormous
applications
advanced
healthcare,
rapid
disease
diagnostics,
persistent
human-machine
interfaces.
Soft,
contoured
geometries
time-dynamic
deformation
of
the
targeted
tissues
require
high
flexibility
stretchability
integrated
bioelectronics.
Recent
progress
developing
engineering
soft
materials
has
provided
a
unique
opportunity
to
design
various
types
mechanically
compliant
deformable
systems.
Here,
we
summarize
required
properties
their
characteristics
for
configuring
sensing
substrate
components
devices
Details
functionality
sensitivity
recently
developed
FHE
are
discussed
with
application
areas
medicine,
machine
interactions.
This
review
concludes
discussion
on
limitations
current
materials,
key
requirements
next
generation
new
areas.
Materials Advances,
Год журнала:
2021,
Номер
2(6), С. 1821 - 1871
Опубликована: Янв. 1, 2021
Nanomaterials
have
emerged
as
an
amazing
class
of
materials
that
consists
a
broad
spectrum
examples
with
at
least
one
dimension
in
the
range
1
to
100
nm.
Chemical Reviews,
Год журнала:
2019,
Номер
119(8), С. 5461 - 5533
Опубликована: Янв. 28, 2019
Bio-integrated
wearable
systems
can
measure
a
broad
range
of
biophysical,
biochemical,
and
environmental
signals
to
provide
critical
insights
into
overall
health
status
quantify
human
performance.
Recent
advances
in
material
science,
chemical
analysis
techniques,
device
designs,
assembly
methods
form
the
foundations
for
uniquely
differentiated
type
technology,
characterized
by
noninvasive,
intimate
integration
with
soft,
curved,
time-dynamic
surfaces
body.
This
review
summarizes
latest
this
emerging
field
"bio-integrated"
technologies
comprehensive
manner
that
connects
fundamental
developments
chemistry,
engineering
sensing
have
potential
widespread
deployment
societal
benefit
care.
An
introduction
chemistries
materials
active
components
these
contextualizes
essential
design
considerations
sensors
associated
platforms
appear
following
sections.
The
subsequent
content
highlights
most
advanced
biosensors,
classified
according
their
ability
capture
information.
Additional
sections
feature
schemes
electrically
powering
strategies
achieving
fully
integrated,
wireless
systems.
concludes
an
overview
key
remaining
challenges
summary
opportunities
where
chemistry
will
be
critically
important
continued
progress.
Chemical Society Reviews,
Год журнала:
2017,
Номер
46(22), С. 7021 - 7053
Опубликована: Янв. 1, 2017
Chemotherapy
is
currently
one
of
the
most
effective
ways
to
treat
cancer.
However,
traditional
chemotherapy
faces
several
obstacles
clinical
trials,
such
as
poor
solubility/stability,
non-targeting
capability
and
uncontrollable
release
drugs,
greatly
limiting
their
anticancer
efficacy
causing
severe
side
effects
towards
normal
tissues.
Supramolecular
integrating
non-covalent
interactions
a
highly
promising
candidate
in
this
regard
can
be
appropriately
used
for
targeted
drug
delivery.
By
taking
advantage
supramolecular
chemistry,
some
limitations
impeding
applications
solved
effectively.
Therefore,
we
present
here
review
summarizing
progress
cancer
treatment
based
on
host-guest
recognition
provide
guidance
design
new
targeting
combining
diagnostic
therapeutic
functions.
Based
large
number
state-of-the-art
studies,
our
will
advance
basis
promote
translational
applications.
Chemical Society Reviews,
Год журнала:
2019,
Номер
48(11), С. 2891 - 2912
Опубликована: Янв. 1, 2019
The
emergence
of
novel
two-dimensional
(2D)
monoelemental
materials
(Xenes)
has
shown
remarkable
potential
for
their
applications
in
different
fields
technology,
as
well
addressing
new
discoveries
fundamental
science.
Xenes
(e.g.,
borophene,
silicene,
germanene,
stanene,
phosphorene,
arsenene,
antimonene,
bismuthene,
and
tellurene)
are
particular
interest
because
they
the
most
chemically
tractable
synthetic
exploration.
Owing
to
excellent
physical,
chemical,
electronic
optical
properties,
have
been
regarded
promising
agents
biosensors,
bioimaging,
therapeutic
delivery,
theranostics,
several
other
bio-applications.
In
this
tutorial
review,
we
summarize
general
properties
including
classification
according
bulk
properties.
modification
methods
also
presented.
Furthermore,
representative
Xene
nanoplatforms
various
biomedical
highlighted.
Finally,
research
progress,
challenges,
perspectives
future
development
biomedicines
discussed.
Chemical Reviews,
Год журнала:
2021,
Номер
121(4), С. 2545 - 2647
Опубликована: Фев. 5, 2021
Protein
misfolding
and
aggregation
is
observed
in
many
amyloidogenic
diseases
affecting
either
the
central
nervous
system
or
a
variety
of
peripheral
tissues.
Structural
dynamic
characterization
all
species
along
pathways
from
monomers
to
fibrils
challenging
by
experimental
computational
means
because
they
involve
intrinsically
disordered
proteins
most
diseases.
Yet
understanding
how
amyloid
become
toxic
challenge
developing
treatment
for
these
Here
we
review
what
computer,
vitro,
vivo,
pharmacological
experiments
tell
us
about
accumulation
deposition
oligomers
(Aβ,
tau),
α-synuclein,
IAPP,
superoxide
dismutase
1
proteins,
which
have
been
mainstream
concept
underlying
Alzheimer's
disease
(AD),
Parkinson's
(PD),
type
II
diabetes
(T2D),
amyotrophic
lateral
sclerosis
(ALS)
research,
respectively,
years.
Journal of Nanobiotechnology,
Год журнала:
2021,
Номер
19(1)
Опубликована: Янв. 4, 2021
Abstract
Skin
is
the
body’s
first
barrier
against
external
pathogens
that
maintains
homeostasis
of
body.
Any
serious
damage
to
skin
could
have
an
impact
on
human
health
and
quality
life.
Tissue
engineering
aims
improve
damaged
tissue
regeneration.
One
most
effective
treatments
for
regeneration
angiogenesis
during
healing
period.
Over
last
decade,
there
has
been
impressive
growth
new
potential
applications
nanobiomaterials
in
engineering.
Various
approaches
developed
rate
process
using
angiogenic
nanomaterials.
In
this
review,
we
focused
molecular
mechanisms
key
factors
angiogenesis,
role
scaffold-based
accelerated
wound
based
improved
angiogenesis.
ACS Nano,
Год журнала:
2018,
Номер
12(11), С. 10582 - 10620
Опубликована: Ноя. 2, 2018
Graphene
and
its
derivatives
are
heralded
as
"miracle"
materials
with
manifold
applications
in
different
sectors
of
society
from
electronics
to
energy
storage
medicine.
The
increasing
exploitation
graphene-based
(GBMs)
necessitates
a
comprehensive
evaluation
the
potential
impact
these
on
human
health
environment.
Here,
we
discuss
synthesis
characterization
GBMs
well
environmental
hazard
assessment
using
vitro
vivo
model
systems
aim
understand
properties
that
underlie
biological
effects
materials;
not
all
alike,
it
is
essential
disentangle
structure–activity
relationships
for
this
class
materials.
Advanced Functional Materials,
Год журнала:
2019,
Номер
29(13)
Опубликована: Фев. 4, 2019
Abstract
Black
phosphorus
(BP)
has
increasingly
attracted
scientific
attention
since
its
first
applications
in
biomedicine
due
to
unique
properties
and
excellent
biocompatibility.
In
particular,
layer‐dependent
bandgap,
moderate
carrier
mobility,
large
surface‐area‐to‐volume
ratio,
biodegradability,
intrinsic
photoacoustic
properties,
biocompatibility
make
it
an
ideal
candidate
for
use
photothermal
therapy,
photodynamic
drug
delivery,
3D
printing,
bioimaging,
biosensing,
theranostics,
which
are
reviewed
here.
addition,
the
article
discusses
strategies
overcome
challenges
related
surface
instability
chemical
degradation,
a
major
obstacle
application.
This
review
not
only
provides
comprehensive
summary
on
BP
preparation
biomedical
but
also
summarizes
recent
research
future
possibilities.
Frontiers in Neuroscience,
Год журнала:
2018,
Номер
12
Опубликована: Янв. 21, 2018
Graphene
displays
properties
that
make
it
appealing
for
neuroregenerative
medicine,
yet
its
interaction
with
peripheral
neurons
has
been
scarcely
investigated.
Here,
we
culture
on
graphene
two
established
models
neurons:
PC12
cells
and
DRG
primary
neurons.
We
perform
a
nano-resolved
analysis
of
polymeric
coatings
combine
optical
microscopy
viability
assays
to
assess
the
material
cytocompatibility
influence
differentiation.
find
differentiated
display
remarkably
increased
neurite
length
(up
27%)
respect
controls.
Notably,
survive
both
bare
coated
graphene.
They
present
dense
axonal
networks
graphene,
while
they
form
cell
islets
characterized
by
bundles
uncoated
These
findings
indicate
holds
potential
nerve
tissue
regeneration
might
pave
road
novel
concepts
active
conduits.
