Insights into 2D MXenes for Versatile Biomedical Applications: Current Advances and Challenges Ahead

Advanced Science, Год журнала: 2018, Номер 5(10)

Опубликована: Июль 19, 2018

Great and interdisciplinary research efforts have been devoted to the biomedical applications of 2D materials because their unique planar structure prominent physiochemical properties. Generally, ceramic-based biomaterials, fabricated by high-temperature solid-phase reactions, are preferred as bone scaffolds in hard tissue engineering controllable biocompatibility satisfactory mechanical property, but potential disease theranostics paid much less attention, mainly due lack related material functionalities for possibly entering circulating within vascular system. The emerging MXenes, a family ultrathin atomic nanosheet derived from MAX phase ceramics, currently booming novel inorganic nanosystems biologic applications. metallic conductivity, hydrophilic nature, other performances make it possible MXenes meet strict requirements biomedicine. This work introduces very recent progress paradigms state-of-the-art applications, focusing on design/synthesis strategies, therapeutic modalities, diagnostic imaging, biosensing, antimicrobial, biosafety issues. It is highly expected that elaborately engineered nanosheets will become one most attractive biocompatible nanoplatforms multiple extensive profit clinical translation nanomedicine.

Язык: Английский

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Strategies for reduction of graphene oxide – A comprehensive review

Chemical Engineering Journal, Год журнала: 2020, Номер 405, С. 127018 - 127018

Опубликована: Сен. 15, 2020

Язык: Английский

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A Review on Graphene-Based Nanomaterials in Biomedical Applications and Risks in Environment and Health

Nano-Micro Letters, Год журнала: 2018, Номер 10(3)

Опубликована: Май 21, 2018

Graphene-based nanomaterials (GBNs) have attracted increasing interests of the scientific community due to their unique physicochemical properties and applications in biotechnology, biomedicine, bioengineering, disease diagnosis therapy. Although a large amount researches been conducted on these novel nanomaterials, limited comprehensive reviews are published biomedical potential environmental human health effects. The present research aimed at addressing this knowledge gap by examining discussing: (1) history, synthesis, structural recent developments GBNs for applications; (2) uses as therapeutics, drug/gene delivery antibacterial materials; (3) tissue engineering biosensors bioimaging (4) effects risks. It also discussed perspectives challenges associated with GBNs.

Язык: Английский

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Graphene‐Based Smart Platforms for Combined Cancer Therapy

Advanced Materials, Год журнала: 2018, Номер 31(9)

Опубликована: Июль 24, 2018

The extensive research of graphene and its derivatives in biomedical applications during the past few years has witnessed significance field nanomedicine. Starting from simple drug delivery systems, application been extended to a versatile platform multiple therapeutic modalities, including photothermal therapy, photodynamic magnetic hyperthermia sonodynamic therapy. In addition monotherapy, graphene-based materials are widely applied combined therapies for enhanced anticancer activity reduced side effects. particular, often designed fabricated as "smart" platforms stimuli-responsive nanocarriers, whose effects can be activated by tumor microenvironment, such acidic pH elevated glutathione (termed "endogenous stimuli"), or light, magnetic, ultrasonic stimuli "exogenous stimuli"). Herein, recent advances smart therapy presented, starting with principle design applications. Next, contributed materials, chemotherapy-based, photothermal-therapy-based, ultrasound-therapy-based synergistic outlined. addition, current challenges future prospects regarding this promising discussed.

Язык: Английский

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Graphene-Based Sensors for Human Health Monitoring

Frontiers in Chemistry, Год журнала: 2019, Номер 7

Опубликована: Июнь 11, 2019

Since the desire for real-time human health monitoring as well seamless human-machine interaction is increasing rapidly, plenty of research efforts have been made to investigate wearable sensors and implantable devices in recent years. As a novel 2D material, graphene has aroused boom field sensor around world due its advantages mechanical, thermal, electrical properties. Numerous graphene-based used reported, including sensors, devices, which can realize measurement body temperature, heart rate, pulse oxygenation, respiration blood pressure, glucose, electrocardiogram signal, electromyogram electroencephalograph etc. Herein, review latest monitoring, their structures, sensing mechanisms, technological innovations, components systems potential challenges will be discussed outlined.

Язык: Английский

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Emerging graphitic carbon nitride-based materials for biomedical applications

Progress in Materials Science, Год журнала: 2020, Номер 112, С. 100666 - 100666

Опубликована: Март 9, 2020

Язык: Английский

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Graphene oxide and carbon dots as broad-spectrum antimicrobial agents – a minireview

Nanoscale Horizons, Год журнала: 2018, Номер 4(1), С. 117 - 137

Опубликована: Сен. 5, 2018

Complex antibacterial mechanisms of graphene oxide and carbon dots.

Язык: Английский

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Two-dimensional nanomaterials: fascinating materials in biomedical field

Science Bulletin, Год журнала: 2019, Номер 64(22), С. 1707 - 1727

Опубликована: Сен. 20, 2019

Язык: Английский

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Hollow Cu₂Se Nanozymes for Tumor Photothermal-Catalytic Therapy

Chemistry of Materials, Год журнала: 2019, Номер 31(16), С. 6174 - 6186

Опубликована: Июль 29, 2019

Tumor microenvironment (TME)-mediated cancer therapy, such as chemodynamic therapy (CDT) based on Fenton reaction, has attracted extensive attention in recent years. However, efficient reactions usually require stringent reaction conditions (low pH value and sufficient H2O2). Therefore, there is an urgent need to improve the efficiency of within tumor for enhanced CDT treatment. Herein, Cu2Se hollow nanocubes (HNCs) are successfully prepared via anion exchange method using Cu2O (NCs) template. This also used synthesize Cu2S or CuSSe HNCs with similar structure. By tuning time process transforming NCs into HNCs, optimized performances high NIR II photothermal conversion (50.89%) good Fenton-like properties obtained. After surface coating, PEGylated show water dispersibility biocompatibility. Importantly, vitro vivo experiments demonstrate significant synergistic effect combining (PTT) PEG-Cu2Se achieving greatly efficacy than that obtained by PTT alone. Moreover, appear be rather safe treated animals without noticeable long-term toxicity.

Язык: Английский

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2D Covalent Organic Frameworks for Biomedical Applications

Advanced Functional Materials, Год журнала: 2020, Номер 30(27)

Опубликована: Апрель 29, 2020

Abstract Covalent organic frameworks (COFs) are an emerging class of crystalline polymers with well‐defined molecular geometry and tunable porosity. COFs formed via reversible condensation lightweight building blocks, which dictate its in two or three dimensions. Among COFs, 2D have garnered special attention due to their unique structure composed two‐dimensionally extended sheets stacked layers generating periodic columnar π‐arrays, functional pore space, ease synthesis. These features combination low density, high crystallinity, large surface area, biodegradability made them excellent candidate for a plethora applications ranging from energy biomedical sciences. In this article, the evolution is briefly discussed terms different types chemical linkages, synthetic strategies bulk nanoscale tunability perspective. Next, specifically drug delivery, phototherapy, biosensing, bioimaging, biocatalysis, antibacterial activity summarized. addition, current challenges approaches designing advanced discussed.

Язык: Английский

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