Hierarchically oriented organization in supramolecular peptide crystals

Nature Reviews Chemistry, Год журнала: 2019, Номер 3(10), С. 567 - 588

Опубликована: Сен. 10, 2019

Язык: Английский

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Peptide-Based Supramolecular Systems Chemistry

Chemical Reviews, Год журнала: 2021, Номер 121(22), С. 13869 - 13914

Опубликована: Сен. 14, 2021

Peptide-based supramolecular systems chemistry seeks to mimic the ability of life forms use conserved sets building blocks and chemical reactions achieve a bewildering array functions. Building on design principles for short peptide-based nanomaterials with properties, such as self-assembly, recognition, catalysis, actuation, are increasingly available. is starting address far greater challenge systems-level access complex functions that emerge when multiple interactions coordinated integrated. We discuss key features relevant design, including regulating order disorder, development active adaptive by considering kinetic thermodynamic aspects combinatorial dynamic covalent noncovalent interactions. Finally, we how structural concepts, preorganization induced fit, critical develop materials tunable photonic, electronic, catalytic properties. highlight examples where combined, resulting in display properties cannot be achieved without this level integration.

Язык: Английский

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Supramolecular Photothermal Effects: A Promising Mechanism for Efficient Thermal Conversion

Angewandte Chemie International Edition, Год журнала: 2019, Номер 59(10), С. 3793 - 3801

Опубликована: Окт. 1, 2019

Abstract Supramolecular assemblies have been very successful in regulating the photothermal conversion efficiency of organic materials a simple and flexible way, compared with conventional molecular synthesis. In these assemblies, it is inherent physiochemical mechanism that determines conversion, rather than assembly strategy. This Minireview summarizes supramolecular effects, which refer to unique features chemistry for efficiency. Emphasis placed on mechanisms how self‐assembly affects performance. The effects various types light‐harvesting species are discussed detail. timely interpretation promising future design high efficiency, precision, multiple functionalities wide array applications.

Язык: Английский

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Prebiotic Peptides: Molecular Hubs in the Origin of Life

Chemical Reviews, Год журнала: 2020, Номер 120(11), С. 4707 - 4765

Опубликована: Фев. 26, 2020

The fundamental roles that peptides and proteins play in today's biology makes it almost indisputable were key players the origin of life. Insofar as is appropriate to extrapolate back from extant prebiotic world, one must acknowledge critical importance interconnected molecular networks, likely with components, would have played life's origin. In this review, we summarize chemical processes involving could contributed early evolution, an emphasis on interactions between other classes organic molecules. We first mechanisms by which amino acids similar building blocks been produced elaborated into proto-peptides. Next, non-covalent well nucleic acids, lipids, carbohydrates, metal ions, aromatic molecules are discussed relation possible such evolution structure function. Finally, describe research structural alternatives covalent adducts acids/peptides propose ample future breakthroughs origin-of-life chemistry will stem investigations systems synergistic different emerge.

Язык: Английский

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Self-Assembled Minimalist Multifunctional Theranostic Nanoplatform for Magnetic Resonance Imaging-Guided Tumor Photodynamic Therapy

ACS Nano, Год журнала: 2018, Номер 12(8), С. 8266 - 8276

Опубликована: Авг. 9, 2018

Minimalist multifunctional platforms for delivering diagnostic and therapeutic agents effectively safely into tumor sites are highly desired in nanomedicine. Herein, we describe the fabrication of a supramolecular nanoplatform via amphiphilic amino acid (9-fluorenylmethyloxycarbonyl-l-leucine, Fmoc-l-L)-modulated self-assembly magnetic resonance imaging (MRI) contrast agent (ionic manganese, Mn2+) photosensitive drug (chlorin e6, Ce6). Coordination drives coassembly Fmoc-l-L Mn2+ to generate nanoscale network adaptively encapsulate Ce6. The obtained biometal–organic nanoparticles exhibit high loading capability, inherent good biocompatibility, robust stability, smart disassembly response glutathione (GSH). cooperative assembly multiple components is synchronously dynamic nature enables enhanced photodynamic therapy (PDT) damage cells tissue by efficiently photosensitizer improving reductive microenvironment competitive coordination GSH with Mn2+. antitumor effect can also be monitored evaluated vivo MRI through long-term intracellular biochelation Therefore, this work presents one-pot method theranostic capable MRI-guided PDT starting from minimalist biological building blocks.

Язык: Английский

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Crystallization‐Driven Asymmetric Helical Assembly of Conjugated Block Copolymers and the Aggregation Induced White‐light Emission and Circularly Polarized Luminescence

Angewandte Chemie International Edition, Год журнала: 2020, Номер 59(38), С. 16675 - 16682

Опубликована: Июнь 16, 2020

Controlling the self-assembly morphology of π-conjugated block copolymer is great interesting. Herein, amphiphilic poly(3-hexylthiophene)-block-poly(phenyl isocyanide)s (P3HT-b-PPI) copolymers composed P3HT and optically active helical PPI segments were readily prepared. Taking advantage crystallizable nature chirality segment, crystallization-driven asymmetric (CDASA) lead to formation single-handed nanofibers with controlled length, narrow dispersity, well-defined helicity. During process, was transferred supramolecular assemblies, giving assemblies large optical activity. The exhibited interesting white-light emission circularly polarized luminescence (CPL). handedness dissymmetric factor induced CPL can be finely tuned through variation on helicity length nanofibers.

Язык: Английский

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Metal-Ion Modulated Structural Transformation of Amyloid-Like Dipeptide Supramolecular Self-Assembly

ACS Nano, Год журнала: 2019, Номер 13(6), С. 7300 - 7309

Опубликована: Июнь 10, 2019

The misfolding of proteins and peptides potentially leads to a conformation transition from an α-helix or random coil β-sheet-rich fibril structures, which are associated with various amyloid degenerative disorders. Inhibition the β-sheet aggregate formation control structural could therefore attenuate development amyloid-associated diseases. However, transitions extraordinarily complex processes that still not fully understood thus challenging manipulate. To simplify this complexity, herein, effect metal ions on inhibition amyloid-like dipeptide self-assembly is investigated. By changing type ratio ion/dipeptide mixture, transformation achieved superhelix coil, as confirmed by experimental results computational studies. Furthermore, obtained supramolecular metallogel exhibits excellent in vitro DNA binding diffusion capability due positive charge metal/dipeptide complex. This work may facilitate understanding role inhibiting broaden future applications metallogels three-dimensional (3D) biochip, cell culture, drug delivery.

Язык: Английский

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Dynamic responsiveness of self‐assembling peptide‐based nano‐drug systems

Deleted Journal, Год журнала: 2023, Номер 1(1)

Опубликована: Янв. 1, 2023

Abstract Dynamic‐responsive self‐assembly is the process of ordered supramolecular structure formation or reversible decomposition from building blocks. This driven by non‐covalent interactions based on complex stimulus‐responsive systems comprising different components within a microenvironment. Furthermore, stimuli‐responsive assembly‐disassembly an intrinsic interaction in organisms, indispensable maintaining life activities and functions. However, dynamic between dynamically responsive nano‐drug (DRNSs) biological remain unpredictable, which are challenge for precisely targeted therapy controlled drug release DRNSs vivo. review highlights novel self‐assembling peptide‐based their interactions. By controlling shape size self‐assembled peptide nanomaterials, biologically simulated with diverse functions precise transport at subcellular level can be achieved. We have also summarized limitations challenges nanomaterials clinical translation. Additionally, we discussed future perspectives therapeutics using signaling molecule gradient concentrations efficiencies highlighted direction developing clinically translatable smart nanomedicines.

Язык: Английский

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Physical strategies to engineer supramolecular composite hydrogels for advanced biomedical applications

Progress in Materials Science, Год журнала: 2025, Номер 151, С. 101428 - 101428

Опубликована: Янв. 9, 2025

Язык: Английский

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Tyrosine‐Rich Peptides as a Platform for Assembly and Material Synthesis

Advanced Science, Год журнала: 2018, Номер 6(4)

Опубликована: Ноя. 15, 2018

Abstract The self‐assembly of biomolecules can provide a new approach for the design functional systems with diverse range hierarchical nanoarchitectures and atomically defined structures. In this regard, peptides, particularly short are attractive building blocks because their ease establishing structure–property relationships, productive synthesis, possibility hybridization other motifs. Several assembling such as ionic‐complementary cyclic peptide amphiphiles, Fmoc‐peptide, aromatic dipeptides, widely studied. Recently, studies on material synthesis application tyrosine‐rich peptide‐based have demonstrated that tyrosine units serve not only excellent assembly motifs but also multifunctional templates. Tyrosine has phenolic group contributes to π–π interactions conformation control efficient charge transport by proton‐coupled electron‐transfer reactions in natural systems. Here, critical roles motif respect its electrochemical, chemical, structural properties discussed recent discoveries advances made from self‐assembled structures peptide/inorganic hybrid materials highlighted. A brief account opportunities optimization applications biomimetic is included.

Язык: Английский

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