ACS Nano,
Год журнала:
2022,
Номер
16(9), С. 13513 - 13553
Опубликована: Сен. 1, 2022
Prodrugs
are
chemically
modified
drug
molecules
that
inactive
before
administration.
After
administration,
they
converted
in
situ
to
parent
drugs
and
induce
the
mechanism
of
action.
The
development
prodrugs
has
upgraded
conventional
treatments
terms
bioavailability,
targeting,
reduced
side
effects.
Especially
cancer
therapy,
application
achieved
substantial
therapeutic
From
serendipitous
discovery
early
stage
functional
design
with
pertinence
nowadays,
importance
is
self-evident.
At
present,
studying
stimuli-responsive
activation
mechanisms,
regulating
stimuli
intensity
vivo,
designing
nanoscale
prodrug
formulations
major
strategies
promote
prodrugs.
In
this
review,
we
provide
an
outlook
recent
cutting-edge
studies
on
nanosystems
from
these
three
aspects.
We
also
discuss
prospects
challenges
future
such
Chemical Reviews,
Год журнала:
2019,
Номер
119(16), С. 9657 - 9721
Опубликована: Июль 15, 2019
Calix[n]arenes
(n
=
4,
5,
6,
8)
are
"chalicelike"
phenol-based
macrocycles
that
among
the
most
fascinating
and
highly
studied
scaffolds
in
supramolecular
chemistry.
This
stems
from
functional
tunable
diversity
at
both
their
upper
lower
rims,
preorganized
nonpolar
cavities
ion-binding
sites,
well-defined
conformations.
Conjugation
of
calixarene
with
various
fluorogenic
groups
has
led
to
development
smart
fluorescent
probes
have
been
utilized
as
molecular
sensors,
bioimaging,
for
drug
gene
delivery,
self-assembly/aggregation,
materials.
The
fine-tuning
incorporation
different
ligating
sites
calix[4]arene
scaffold
produced
numerous
sensors
cations,
anions,
biomolecules.
Moreover,
aqueous
solubility
p-sulfonatocalix[4]arenes
engendered
potential
use
drug/gene
delivery
enzymatic
assays.
In
addition,
because
strong
optical
properties,
calix[4]arenes
used
develop
materials,
including
gels
well
nonlinear
optical,
organic
light-emitting
diode,
multiphoton
Finally,
significant
developments
utility
higher
calixarenes
made
bioapplications.
review
critically
summarizes
recent
advances
all
these
areas.
Chemical Society Reviews,
Год журнала:
2021,
Номер
50(20), С. 11614 - 11667
Опубликована: Янв. 1, 2021
Magnetic
hyperthermia
(MHT)
is
a
therapeutic
modality
for
the
treatment
of
solid
tumors
that
has
now
accumulated
more
than
30
years
experience.
In
ongoing
MHT
clinical
trials
brain
and
prostate
tumors,
iron
oxide
nanoparticles
are
employed
as
intra-tumoral
agents
under
patient-safe
100
kHz
alternating
magnetic
field
(AMF)
applicator.
Although
currently
approved
by
FDA
imaging
purposes
anemia,
(MNPs)
designed
efficient
must
respond
to
specific
physical-chemical
properties
in
terms
magneto-energy
conversion,
heat
dose
production,
surface
chemistry
aggregation
state.
Accordingly,
past
few
decades,
these
requirements
have
boosted
development
new
generation
MNPs
specifically
aimed
MHT.
this
review,
we
present
an
overview
on
their
assemblies
produced
via
different
synthetic
routes,
focusing
which
MNP
features
allowed
unprecedented
heating
efficiency
levels
be
achieved
highlighting
nanoplatforms
prevent
loss
intracellular
environment.
Moreover,
review
advances
MNP-based
embrace
concept
multimodal
therapy,
aims
combine
with
chemotherapy,
radiotherapy,
immunotherapy,
photodynamic
or
phototherapy.
Next,
better
control
temperature
at
tumor,
focus
studies
optimized
maintain
gold-standard
performance
also
tackling
aim
quantitatively
assess
amount
tumor
site
regulate
conditions.
To
conclude,
future
perspectives
guidance
how
advance
therapy
will
provided.
Journal of the American Chemical Society,
Год журнала:
2020,
Номер
142(11), С. 5380 - 5388
Опубликована: Фев. 27, 2020
Tumor
hypoxia
has
proven
to
be
the
major
bottleneck
of
photodynamic
therapy
(PDT)
clinical
transformation.
Different
from
traditional
O2
delivery
approaches,
here
we
describe
an
innovative
binary
O2-economizer
(PDOE)
tactic
reverse
hypoxia-driven
resistance
by
designing
a
superoxide
radical
(O2•–)
generator
targeting
mitochondria
respiration,
termed
SORgenTAM.
This
PDOE
system
is
able
block
intracellular
consumption
and
down-regulate
HIF-1α
expression,
which
successfully
rescues
cancer
cells
becoming
hypoxic
relieves
intrinsic
burden
tumors
in
vivo,
thereby
sparing
sufficient
endogenous
for
PDT
process.
Photosensitization
mechanism
studies
demonstrate
that
SORgenTAM
ideal
intersystem
crossing
rate
triplet
excited
state
lifetime
generating
O2•–
through
type-I
photochemistry,
generated
can
further
trigger
biocascade
reduce
PDT's
demand
O2-recycble
manner.
Furthermore,
also
serves
activate
AMPK
metabolism
signaling
pathway
inhibit
cell
repair
promote
death.
Consequently,
using
this
two-step
O2-economical
strategy,
under
relatively
low
light
dose
irradiation,
excellent
therapeutic
responses
toward
are
achieved.
study
offers
conceptual
while
practical
paradigm
overcoming
pitfalls
phototherapeutics.
Journal of Hematology & Oncology,
Год журнала:
2022,
Номер
15(1)
Опубликована: Сен. 12, 2022
Poor
targeting
of
therapeutics
leading
to
severe
adverse
effects
on
normal
tissues
is
considered
one
the
obstacles
in
cancer
therapy.
To
help
overcome
this,
nanoscale
drug
delivery
systems
have
provided
an
alternative
avenue
for
improving
therapeutic
potential
various
agents
and
bioactive
molecules
through
enhanced
permeability
retention
(EPR)
effect.
Nanosystems
with
cancer-targeted
ligands
can
achieve
effective
tumor
cells
utilizing
cell
surface-specific
receptors,
vasculature
antigens
high
accuracy
affinity.
Additionally,
stimuli-responsive
nanoplatforms
also
been
as
a
promising
strategy
against
tumors,
these
maintain
their
stealth
feature
under
conditions,
but
upon
homing
cancerous
lesions
or
microenvironment,
are
responsive
release
cargoes.
In
this
review,
we
comprehensively
summarize
field
active
number
studies
context
emerging
nanoplatform
development,
discuss
how
knowledge
contribute
further
improvements
clinical
practice.
Materials Horizons,
Год журнала:
2020,
Номер
7(8), С. 2028 - 2046
Опубликована: Янв. 1, 2020
Sonodynamic
therapy
(SDT)
is
a
new
therapeutic
method,
which
can
kill
malignant
tumors
by
using
sonosensitizers
and
low
intensity
ultrasound
(US)
simultaneously.
