Angewandte Chemie International Edition,
Год журнала:
2019,
Номер
58(36), С. 12624 - 12631
Опубликована: Июнь 25, 2019
Abstract
Nanozymes
have
attracted
extensive
interest
owing
to
their
high
stability,
low
cost
and
easy
preparation,
especially
in
the
field
of
cancer
therapy.
However,
relatively
catalytic
activity
nanozymes
tumor
microenvironment
(TME)
has
limited
applications.
Herein,
we
report
a
novel
nanozyme
(PtFe@Fe
3
O
4
)
with
dual
enzyme‐like
activities
for
highly
efficient
PtFe@Fe
shows
intrinsic
photothermal
effect
as
well
photo‐enhanced
peroxidase‐like
catalase‐like
acidic
TME,
thereby
effectively
killing
cells
overcoming
hypoxia.
Importantly,
possible
synergistic
mechanism
was
first
disclosed.
We
believe
that
this
work
will
advance
development
Chemical Reviews,
Год журнала:
2019,
Номер
119(6), С. 4357 - 4412
Опубликована: Фев. 25, 2019
Because
of
the
high
catalytic
activities
and
substrate
specificity,
natural
enzymes
have
been
widely
used
in
industrial,
medical,
biological
fields,
etc.
Although
promising,
they
often
suffer
from
intrinsic
shortcomings
such
as
cost,
low
operational
stability,
difficulties
recycling.
To
overcome
these
shortcomings,
researchers
devoted
to
exploration
artificial
enzyme
mimics
for
a
long
time.
Since
discovery
ferromagnetic
nanoparticles
with
horseradish
peroxidase-like
activity
2007,
large
amount
studies
on
nanozymes
constantly
emerging
next
decade.
Nanozymes
are
one
kind
nanomaterials
enzymatic
properties.
Compared
enzymes,
advantages
stability
durability,
which
fields.
A
thorough
understanding
possible
mechanisms
will
contribute
development
novel
high-efficient
nanozymes,
rational
regulations
great
significance.
In
this
review,
we
systematically
introduce
classification,
mechanism,
regulation
well
recent
research
progress
field
biosensing,
environmental
protection,
disease
treatments,
past
years.
We
also
propose
current
challenges
their
future
focus.
anticipate
review
may
be
significance
understand
properties
mimicking
activities.
Materials Advances,
Год журнала:
2021,
Номер
2(6), С. 1821 - 1871
Опубликована: Янв. 1, 2021
Nanomaterials
have
emerged
as
an
amazing
class
of
materials
that
consists
a
broad
spectrum
examples
with
at
least
one
dimension
in
the
range
1
to
100
nm.
Accounts of Chemical Research,
Год журнала:
2019,
Номер
52(8), С. 2190 - 2200
Опубликована: Июль 5, 2019
ConspectusNanozymes
are
nanomaterials
with
intrinsic
enzyme-like
characteristics
that
have
been
booming
over
the
past
decade
because
of
their
capability
to
address
limitations
natural
enzymes
such
as
low
stability,
high
cost,
and
difficult
storage.
Along
rapid
development
ever-deepening
understanding
nanoscience
nanotechnology,
nanozymes
hold
promise
serve
direct
surrogates
traditional
by
mimicking
further
engineering
active
centers
enzymes.
In
2007,
we
reported
first
evidence
Fe3O4
nanoparticles
(NPs)
peroxidase-mimicking
activity,
since
time,
hundreds
found
mimic
catalytic
activity
peroxidase,
oxidase,
catalase,
haloperoxidase,
glutathione
uricase,
methane
monooxygenase,
hydrolase,
superoxide
dismutase.
Uniquely,
a
broad
variety
simultaneously
exhibit
dual-
or
multienzyme
mimetic
activity.
For
example,
NPs
show
pH-dependent
peroxidase-like
catalase-like
activities;
Prussian
blue
possess
peroxidase-,
catalase-,
dismutase-like
activity;
Mn3O4
all
three
cellular
antioxidant
including
dismutase,
peroxidase.
Taking
advantage
physiochemical
properties
nanomaterials,
shown
range
applications
from
in
vitro
detection
replacing
specific
living
systems.
With
emergence
new
concept
"nanozymology",
now
become
an
emerging
field
connecting
nanotechnology
biology.Since
landmark
paper
on
was
published
extensively
explored
mechanism,
established
corresponding
standards
quantitatively
determine
activities,
opened
up
biological
environmental
monitoring
disease
diagnosis
biomedicine
development.
Here
mainly
focus
our
progress
systematic
design
construction
functionally
nanozymes,
standardization
nanozyme
research,
exploration
for
We
also
that,
combining
unique
physicochemical
can
offer
multifunctional
platforms
vivo
therapy.
instance,
targeting
antibody-conjugated
ferromagnetic
provide
functions:
target
capture,
magnetic
separation,
color
detection.
finally
will
prospect
research
"nanozymology".
expect
enzyme-mimicking
attract
interest
both
fundamental
practical
opportunities
enzymology.
Metal-organic
frameworks
(MOFs)
are
an
interesting
and
useful
class
of
coordination
polymers,
constructed
from
metal
ion/cluster
nodes
functional
organic
ligands
through
bonds,
have
attracted
extensive
research
interest
during
the
past
decades.
Due
to
unique
features
diverse
compositions,
facile
synthesis,
easy
surface
functionalization,
high
areas,
adjustable
porosity,
tunable
biocompatibility,
MOFs
been
widely
used
in
hydrogen/methane
storage,
catalysis,
biological
imaging
sensing,
drug
delivery,
desalination,
gas
separation,
magnetic
electronic
devices,
nonlinear
optics,
water
vapor
capture,
etc.
Notably,
with
rapid
development
synthetic
methods
functionalization
strategies,
smart
MOF-based
nanocomposites
advanced
bio-related
properties
designed
fabricated
meet
growing
demands
MOF
materials
for
biomedical
applications.
This
work
outlines
synthesis
recent
advances
fields,
including
cargo
(drugs,
nucleic
acids,
proteins,
dyes)
delivery
cancer
therapy,
bioimaging,
antimicrobial,
biosensing,
biocatalysis.
The
prospects
challenges
field
also
discussed.
Conventional
nanozyme
technologies
face
formidable
challenges
of
intricate
size-,
composition-,
and
facet-dependent
catalysis
inherently
low
active
site
density.
We
discovered
a
new
class
single-atom
nanozymes
with
atomically
dispersed
enzyme-like
sites
in
nanomaterials,
which
significantly
enhanced
catalytic
performance,
uncovered
the
underlying
mechanism.
With
oxidase
as
model
reaction,
experimental
studies
theoretical
calculations
revealed
that
carbon
nanoframe-confined
FeN5
centers
(FeN5
SA/CNF)
catalytically
behaved
like
axial
ligand-coordinated
heme
cytochrome
P450.
The
definite
moieties
crucial
synergistic
effects
endow
SA/CNF
clear
electron
push-effect
mechanism,
well
highest
oxidase-like
activity
among
other
(the
rate
constant
is
70
times
higher
than
commercial
Pt/C)
versatile
antibacterial
applications.
These
suggest
have
great
potential
to
become
next-generation
nanozymes.
ACS Nano,
Год журнала:
2023,
Номер
17(6), С. 5211 - 5295
Опубликована: Март 9, 2023
Humans
rely
increasingly
on
sensors
to
address
grand
challenges
and
improve
quality
of
life
in
the
era
digitalization
big
data.
For
ubiquitous
sensing,
flexible
are
developed
overcome
limitations
conventional
rigid
counterparts.
Despite
rapid
advancement
bench-side
research
over
last
decade,
market
adoption
remains
limited.
To
ease
expedite
their
deployment,
here,
we
identify
bottlenecks
hindering
maturation
propose
promising
solutions.
We
first
analyze
achieving
satisfactory
sensing
performance
for
real-world
applications
then
summarize
issues
compatible
sensor-biology
interfaces,
followed
by
brief
discussions
powering
connecting
sensor
networks.
Issues
en
route
commercialization
sustainable
growth
sector
also
analyzed,
highlighting
environmental
concerns
emphasizing
nontechnical
such
as
business,
regulatory,
ethical
considerations.
Additionally,
look
at
future
intelligent
sensors.
In
proposing
a
comprehensive
roadmap,
hope
steer
efforts
towards
common
goals
guide
coordinated
development
strategies
from
disparate
communities.
Through
collaborative
efforts,
scientific
breakthroughs
can
be
made
sooner
capitalized
betterment
humanity.
