Analytical Chemistry,
Год журнала:
2022,
Номер
94(50), С. 17439 - 17447
Опубликована: Дек. 7, 2022
Nonalcoholic
fatty
liver
disease
(NAFLD)
is
a
global
health
issue.
Peroxynitrite
and
viscosity
have
recently
been
found
to
be
potential
biomarkers
of
NAFLD.
Therefore,
it
great
significance
develop
dual-response
fluorescent
probes
for
simultaneous
detecting
peroxynitrite
viscosity.
We
report
herein
new
probe
(CQ)
that
can
simultaneously
detect
at
two
independent
channels
without
signal
crosstalk.
CQ
shows
high
selectivity,
rapid
response,
good
water
solubility,
low
cytotoxicity,
mitochondrial
localization
properties.
In
particular,
responds
sensitively
with
off-on
fluorescence
changes
710
505
nm,
respectively.
The
wavelength
gap
between
these
more
than
200
ensuring
there
no
crosstalk
during
detection.
With
this
property,
the
was
applied
image
concentration
pathogenesis
All
results
show
powerful
tool
detection
provides
diagnostic
method
Analytical Chemistry,
Год журнала:
2022,
Номер
94(50), С. 17439 - 17447
Опубликована: Дек. 7, 2022
Nonalcoholic
fatty
liver
disease
(NAFLD)
is
a
global
health
issue.
Peroxynitrite
and
viscosity
have
recently
been
found
to
be
potential
biomarkers
of
NAFLD.
Therefore,
it
great
significance
develop
dual-response
fluorescent
probes
for
simultaneous
detecting
peroxynitrite
viscosity.
We
report
herein
new
probe
(CQ)
that
can
simultaneously
detect
at
two
independent
channels
without
signal
crosstalk.
CQ
shows
high
selectivity,
rapid
response,
good
water
solubility,
low
cytotoxicity,
mitochondrial
localization
properties.
In
particular,
responds
sensitively
with
off-on
fluorescence
changes
710
505
nm,
respectively.
The
wavelength
gap
between
these
more
than
200
ensuring
there
no
crosstalk
during
detection.
With
this
property,
the
was
applied
image
concentration
pathogenesis
All
results
show
powerful
tool
detection
provides
diagnostic
method
