Frontiers in Microbiology,
Год журнала:
2020,
Номер
11
Опубликована: Сен. 4, 2020
Microorganisms
grow
in
concert,
both
natural
communities
and
artificial
or
synthetic
co-cultures.
Positive
interactions
between
associated
microbes
are
paramount
to
achieve
improved
substrate
conversion
process
performance
biotransformation
fermented
food
production.
The
mechanisms
underlying
such
positive
have
been
the
focus
of
numerous
studies
recent
decades
now
starting
be
well
characterized.
Lactic
acid
bacteria
(LAB)
contribute
final
organoleptic,
nutritional,
health
properties
products.
However,
LAB
co-cultures
little
studied,
apart
from
well-characterized
co-culture
used
for
yogurt
manufacture.
however
multifunctional
microorganisms
that
display
considerable
potential
create
them.
This
review
describes
why
interest,
particularly
foods,
how
their
extensive
nutritional
requirements
can
favor
interactions.
In
respect,
our
highlights
benefits
different
areas
application,
details
aims
show
based
on
exploited
efficient
Trends in biotechnology,
Год журнала:
2018,
Номер
37(2), С. 181 - 197
Опубликована: Ноя. 26, 2018
Microbial
consortia
have
been
used
in
biotechnology
processes,
including
fermentation,
waste
treatment,
and
agriculture,
for
millennia.
Today,
synthetic
biologists
are
increasingly
engineering
microbial
diverse
applications,
the
bioproduction
of
medicines,
biofuels,
biomaterials
from
inexpensive
carbon
sources.
An
improved
understanding
natural
ecosystems,
development
new
tools
to
construct
program
their
behaviors,
will
vastly
expand
functions
that
can
be
performed
by
communities
interacting
microorganisms.
Here,
we
review
recent
advancements
biology
approaches
engineer
consortia,
discuss
ongoing
emerging
efforts
apply
various
biotechnological
suggest
future
applications.
The ISME Journal,
Год журнала:
2019,
Номер
14(2), С. 635 - 648
Опубликована: Ноя. 18, 2019
Diet-microbe
interactions
play
an
important
role
in
modulating
the
early-life
microbiota,
with
Bifidobacterium
strains
and
species
dominating
gut
of
breast-fed
infants.
Here,
we
sought
to
explore
how
infant
diet
drives
distinct
bifidobacterial
community
composition
dynamics
within
individual
ecosystems.
Genomic
characterisation
19
isolated
from
infants
revealed
a
diverse
genomic
architecture
enriched
carbohydrate
metabolism
genes,
which
was
each
strain,
but
collectively
formed
pangenome
across
Presence
gene
clusters
implicated
digestion
human
milk
oligosaccharides
(HMOs)
varied
between
species,
growth
studies
indicating
that
single
there
were
differences
ability
utilise
2'FL
LNnT
HMOs
strains.
Cross-feeding
experiments
performed
HMO
degraders
non-HMO
users
(using
spent
or
'conditioned'
media
direct
co-culture).
Further
1H-NMR
analysis
identified
fucose,
galactose,
acetate,
N-acetylglucosamine
as
key
by-products
metabolism;
demonstrated
by
modest
on
spend
metabolism.
These
indicate
permits
sharing
resources
maximise
nutrient
consumption
highlights
cooperative
nature
their
'foundation'
ecosystem.
The
intra-
inter-infant
behaviour
may
contribute
diversity
dominance
early
life
suggests
avenues
for
future
development
new
microbiota-based
therapies
promote
health.
Proceedings of the National Academy of Sciences,
Год журнала:
2019,
Номер
116(32), С. 15979 - 15984
Опубликована: Июль 3, 2019
Competition
between
microbes
is
extremely
common,
with
many
investing
in
mechanisms
to
harm
other
strains
and
species.
Yet
positive
interactions
species
have
also
been
documented.
What
makes
help
or
each
currently
unclear.
Here,
we
studied
the
4
bacterial
capable
of
degrading
metal
working
fluids
(MWF),
an
industrial
coolant
lubricant,
which
contains
growth
substrates
as
well
toxic
biocides.
We
were
surprised
find
only
neutral
Using
mathematical
modeling
further
experiments,
show
that
this
community
likely
due
toxicity
MWF,
whereby
species'
detoxification
benefited
others
by
facilitating
their
survival,
such
they
could
grow
degrade
MWF
better
when
together.
The
addition
nutrients,
reduction
toxicity,
more
instead
resulted
competitive
behavior.
Our
work
provides
support
stress
gradient
hypothesis
showing
how
harsh,
environments
can
strongly
favor
facilitation
microbial
mask
underlying
interactions.
FEMS Microbiology Reviews,
Год журнала:
2023,
Номер
47(4)
Опубликована: Июль 1, 2023
Abstract
In
humans,
many
diseases
are
associated
with
alterations
in
gut
microbiota,
namely
increases
or
decreases
the
abundance
of
specific
bacterial
groups.
One
example
is
genus
Faecalibacterium.
Numerous
studies
have
underscored
that
low
levels
Faecalibacterium
correlated
inflammatory
conditions,
bowel
disease
(IBD)
forefront.
Its
representation
also
diminished
case
several
diseases,
including
colorectal
cancer
(CRC),
dermatitis,
and
depression.
Additionally,
relative
presence
this
considered
to
reflect,
at
least
part,
intestinal
health
status
because
frequently
present
reduced
individuals
gastrointestinal
disorders.
review,
we
first
thoroughly
describe
updates
taxonomy
Faecalibacterium,
which
has
transformed
a
single-species
taxon
multispecies
over
last
decade.
We
then
explore
links
discovered
between
various
since
IBD-focused
were
published.
Next,
examine
current
available
strategies
for
modulating
gut.
Finally,
summarize
mechanisms
underlying
beneficial
effects
been
attributed
genus.
Together,
epidemiological
experimental
data
strongly
support
use
as
next-generation
probiotic
(NGP)
live
biotherapeutic
product
(LBP).
Genome-scale
metabolic
models
of
microorganisms
are
powerful
frameworks
to
predict
phenotypes
from
an
organism's
genotype.
While
manual
reconstructions
laborious,
automated
often
fail
recapitulate
known
processes.
Here
we
present
gapseq
(
https://github.com/jotech/gapseq
),
a
new
tool
pathways
and
automatically
reconstruct
microbial
using
curated
reaction
database
novel
gap-filling
algorithm.
On
the
basis
scientific
literature
experimental
data
for
14,931
bacterial
phenotypes,
demonstrate
that
outperforms
state-of-the-art
tools
in
predicting
enzyme
activity,
carbon
source
utilisation,
fermentation
products,
interactions
within
communities.
