Marine Life Science & Technology, Год журнала: 2021, Номер 3(3), С. 363 - 374
Опубликована: Янв. 4, 2021
Язык: Английский
Saudi Journal of Biological Sciences, Год журнала: 2020, Номер 28(1), С. 224 - 231
Опубликована: Окт. 9, 2020
The search for novel biologically active molecules has extended to the screening of organisms associated with less explored environments. In this sense, Oceans, which cover nearly 67% globe, are interesting ecosystems characterized by a high biodiversity that is worth being explored. As such, marine microorganisms highly as promising sources new bioactive compounds potential value humans. Some these able survive in extreme environments and, result, they produce complex unique biological properties wide variety industrial and biotechnological applications. Thus, different (fungi, myxomycetes, bacteria, microalgae) producing antioxidant, antibacterial, apoptotic, antitumoral antiviral activities have been already isolated. This review compiles discusses discovery from reported 2018 onwards. Moreover, it highlights huge obtaining valuable compounds.
Язык: Английский
Процитировано
118
Current Protocols in Pharmacology, Год журнала: 2019, Номер 86(1)
Опубликована: Авг. 26, 2019
Many natural products have been used as drugs for the treatment of diverse indications. Although most U.S. pharmaceutical companies reduced or eliminated their in-house natural-product research over years, new approaches compound screening and chemical synthesis are resurrecting interest in exploring therapeutic value products. The aim this commentary is to review emerging strategies techniques that made a viable strategic choice inclusion drug discovery programs. Published 2019. Government.
Язык: Английский
Процитировано
114
International Journal of Biological Macromolecules, Год журнала: 2020, Номер 164, С. 4263 - 4278
Опубликована: Сен. 9, 2020
Язык: Английский
Процитировано
102
Marine Life Science & Technology, Год журнала: 2019, Номер 1(1), С. 60 - 94
Опубликована: Ноя. 1, 2019
Abstract Metabolites from marine organisms have proven to be a rich source for the discovery of multiple potent bioactive molecules with diverse structures. In recent years, we initiated program investigate diversity secondary metabolites invertebrates and their symbiotic microorganisms collected South China Sea. this review, representative cases are summarized focusing on molecular diversity, mining, application natural products these organisms. To provide comprehensive introduction field products, highlight typical including structures, chemical synthesis, bioactivities mechanisms, structure–activity relationships as well biogenesis. The mining marine-derived produce novel is also discussed through OSMAC strategy via partial epigenetic modification. A broad prospectus has revealed plethora structures organisms, especially soft corals, gorgonians, sponges, fungi bacteria.
Язык: Английский
Процитировано
99
Current Research in Biotechnology, Год журнала: 2020, Номер 2, С. 88 - 102
Опубликована: Окт. 1, 2020
Since the early research efforts focusing on bioactive marine substances such as spongouridine, from sponge Cryptotethya crypta, natural products (MNPs) have arisen a robust and sustainable supplier for drug leads. Marine present definite, unprecedented structural diversifications varieties of interesting biomedical potentialities with novel mechanisms action. Until today, eight clinically approved products-based drugs by two worldwide medical organizations (including U.S. FDA, European Medicines Agency (EMEA)), been developed treatment different forms carcinoma, pain, Alzheimer's disease other current challenges. Recent clinical trial analysis disclosed that pipeline contains more than twenty listed candidates in trials phase III, II, or I. Herein, we recent insights centered to preclinically investigated compounds, well sampling techniques, extraction & identification tools, classification MNPs, some reported biological activities, challenges faced during MNPs development.
Язык: Английский
Процитировано
95
Marine Life Science & Technology, Год журнала: 2021, Номер 3(4), С. 488 - 518
Опубликована: Май 19, 2021
Abstract Natural products derived from marine microorganisms have received great attention as a potential resource of new compound entities for drug discovery. The unique environment brings us large group sulfur-containing natural with abundant biological functionality including antitumor, antibiotic, anti-inflammatory and antiviral activities. We reviewed all the 484 (non-sulfated) isolated microorganisms, which 59.9% are thioethers, 29.8% thiazole/thiazoline-containing compounds 10.3% sulfoxides, sulfones, thioesters many others. A selection 133 was further discussed on their structure–activity relationships, mechanisms action, biosynthesis, druggability. This is first systematic review conducted January 1987, when one reported, to December 2020.
Язык: Английский
Процитировано
94
Frontiers in Marine Science, Год журнала: 2020, Номер 7
Опубликована: Май 12, 2020
Marine organisms produce a vast diversity of metabolites with biological activities useful for humans, e.g. cytotoxic, antioxidant, anti-microbial, insecticidal, herbicidal, anticancer, pro-osteogenic and pro-regenerative, analgesic, anti-inflammatory, anti-coagulant, cholesterol-lowering, nutritional, photoprotective, horticultural or other beneficial properties. These could help satisfy the increasing demand alternative sources nutraceuticals, pharmaceuticals, cosmeceuticals, food, feed, novel bio-based products. In addition, marine biomass itself can serve as source material production various bulk commodities (e.g. biofuels, bioplastics, biomaterials). The sustainable exploitation bio-resources development biomolecules polymers are also known growing field biotechnology. Up to now, over 35,000 natural products have been characterized from organisms, but many more yet be uncovered, biota in systems remains largely unexplored. Since biotechnology is still its infancy, there need create effective, operational, inclusive, sustainable, transnational transdisciplinary networks serious ambitious commitment knowledge transfer, training provision, dissemination best practices identification emerging technological trends through science communication activities. A collaborative (net)work today compelling provide innovative solutions that commercialized contribute circular bioeconomy. This perspective article highlights importance establishing such frameworks using example Ocean4Biotech, an Action within European Cooperation Science Technology (COST) connects all any stakeholders interest Europe beyond.
Язык: Английский
Процитировано
89
Food Research International, Год журнала: 2020, Номер 137, С. 109637 - 109637
Опубликована: Авг. 31, 2020
Язык: Английский
Процитировано
87
Marine Drugs, Год журнала: 2020, Номер 18(3), С. 147 - 147
Опубликована: Март 2, 2020
Alkaloids are nitrogenous compounds with various biological activities. anti-inflammatory activity commonly found in terrestrial plants, but there few records of the identification and characterization these marine organisms such as fungi, bacteria, sponges, ascidians, cnidarians. Seaweed a source several already elucidated bioactive compounds, studies have described characterized seaweed alkaloids properties. In this review, we gathered current knowledge about suggest future perspectives for study bioprospecting compounds.
Язык: Английский
Процитировано
86
Marine Drugs, Год журнала: 2019, Номер 17(5), С. 269 - 269
Опубликована: Май 7, 2019
Over the last decade, genome sequences and other -omics datasets have been produced for a wide range of microalgae, several others are on way. Marine microalgae possess distinct unique metabolic pathways, can potentially produce specific secondary metabolites with biological activity (e.g., antipredator, allelopathic, antiproliferative, cytotoxic, anticancer, photoprotective, as well anti-infective antifouling activities). Because very diverse, adapted to broad variety environmental conditions, chances find novel unexplored bioactive properties interest biotechnological biomedical applications high. This review presents comprehensive overview current efforts available solutions produce, explore exploit datasets, aim identifying species strains highest potential identification marine natural products. In addition, funding implementation microalgal resources future perspectives presented well.
Язык: Английский
Процитировано
83