Research Progress on Antibacterial Activities and Mechanisms of Natural Alkaloids: A Review

Antibiotics, Год журнала: 2021, Номер 10(3), С. 318 - 318

Опубликована: Март 19, 2021

Alkaloids are nitrogen-containing heterocyclic compounds typically isolated from plants. They represent one of the most important types natural products because their large number and structural diversity complexity. Based on chemical core structures, alkaloids classified as isoquinolines, quinolines, indoles, piperidine alkaloids, etc. In-depth analyses have revealed antibacterial activities. To date, due to widespread use antibiotics, problem drug-resistant bacterial infections has been gradually increasing, which severely affects clinical efficacy therapies patient safety. Therefore, significant research efforts focused they a potentially new type antibiotic with wide spectrum, rare adverse reactions, low tendency produce drug resistance. Their main mechanisms include inhibition cell wall synthesis, change in membrane permeability, metabolism, nucleic acid protein synthesis. This article reviews recent reports about structures activities alkaloids. The purpose is solve resistance provide certain theoretical basis ideas for development drugs.

Язык: Английский

---

Global seaweed farming and processing in the past 20 years

Food Production Processing and Nutrition, Год журнала: 2022, Номер 4(1)

Опубликована: Окт. 13, 2022

Abstract Seaweed has emerged as one of the most promising resources due to its remarkable adaptability, short development period, and resource sustainability. It is an effective breakthrough alleviate future crises. Algal have reached a high stage growth in past years increased output demand for seaweed worldwide. Several aspects global farming production processing over last 20 are reviewed, such latest situation approaches farming. Research progress trend various application discussed. Besides, challenges faced by also analyzed, related countermeasures proposed, which can provide advice processing. The primary products, extraction application, or waste utilization would bring greater benefits with continuous improvement applications fields. Graphical

Язык: Английский

---

Nano-Drug Delivery Systems Based on Natural Products

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 541 - 569

Опубликована: Янв. 1, 2024

Natural products have proven to significant curative effects and are increasingly considered as potential candidates for clinical prevention, diagnosis, treatment. Compared with synthetic drugs, natural not only diverse structures but also exhibit a range of biological activities against different disease states molecular targets, making them attractive development in the field medicine. Despite advancements use purposes, there remain obstacles that hinder their full potential. These challenges include issues such limited solubility stability when administered orally, well short durations effectiveness. To address these concerns, nano-drug delivery systems emerged promising solution overcome barriers faced application products. offer notable advantages, large specific surface area, enhanced targeting capabilities, ability achieve sustained controlled release. Extensive vitro vivo studies provided further evidence supporting efficacy safety nanoparticle-based delivering preclinical models. This review describes limitations product applications current status combined nanotechnology. The latest advances from three aspects: connecting warheads, self-assembly, co-delivery. Finally, translation nano-drugs discussed.

Язык: Английский

---

Marine algae: A treasure trove of bioactive anti-inflammatory compounds

Marine Pollution Bulletin, Год журнала: 2024, Номер 199, С. 116023 - 116023

Опубликована: Янв. 10, 2024

Язык: Английский

---

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

Marine Drugs, Год журнала: 2020, Номер 18(7), С. 347 - 347

Опубликована: Июль 1, 2020

Beyond their significant contribution to the dietary and industrial supplies, marine algae are considered be a potential source of some unique metabolites with diverse health benefits. The pharmacological properties, such as antioxidant, anti-inflammatory, cholesterol homeostasis, protein clearance anti-amyloidogenic potentials algal endorse protective efficacy against oxidative stress, neuroinflammation, mitochondrial dysfunction, impaired proteostasis which known implicated in pathophysiology neurodegenerative disorders associated complications after cerebral ischemia brain injuries. As was evident various preclinical studies, compounds conferred neuroprotection wide range neurotoxic stressors, oxygen/glucose deprivation, hydrogen peroxide, glutamate, amyloid β, or 1-methyl-4-phenylpyridinium (MPP+) and, therefore, hold therapeutic promise for disorders. While number promising neuroprotective capacity have been identified over last decades, few them had access clinical trials. However, recent approval an oligosaccharide, sodium oligomannate, treatment Alzheimer’s disease enlightened future algae-based drug discovery. In this review, we briefly outline diseases injuries identifying targets intervention, then review literature on along underlying mechanism, present appraisal advances. We also propose rational strategy facilitate metabolites-based development.

Язык: Английский

---

Biological properties and potential of compounds extracted from red seaweeds

Phytochemistry Reviews, Год журнала: 2022, Номер 22(6), С. 1509 - 1540

Опубликована: Июль 1, 2022

Abstract Macroalgae have been recently used for different applications in the food, cosmetic and pharmaceutical industry since they do not compete land freshwater against other resources. Moreover, highlighted as a potential source of bioactive compounds. Red algae (Rhodophyta) are largest group seaweeds, including around 6000 species, thus it can be hypothesized that Sulfated polysaccharides, mainly agar carrageenans, most relevant exploited compounds red algae. Other molecules essential fatty acids, phycobiliproteins, vitamins, minerals, secondary metabolites. All these demonstrated to exert several biological activities, among which antioxidant, anti-inflammatory, antitumor, antimicrobial properties highlighted. Nevertheless, need further tested on vivo experiments go in-depth study mechanism action specific understanding structure–activity relation. At last, extraction technologies correct isolation molecules, cost-effective way, facilitate scale-up processes their application by industry. This manuscript is aimed at describing fundamental composition studied pave way utilization this underused resource.

Язык: Английский

---

Effects of Traditional Chinese Medicine and its Active Ingredients on Drug-Resistant Bacteria

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Июнь 2, 2022

The increasing and widespread application of antibacterial drugs makes antibiotic resistance a prominent growing concern in clinical practice. emergence multidrug-resistant bacteria presents global threat. However, the development use novel agents involves time-consuming costly challenges that may lead to yet further drug resistance. More recently, researchers have turned traditional Chinese medicine stem rise pathogens. Many studies shown medicines significant bacteriostatic bactericidal effects, with advantage low Some which when combined antibiotics, also demonstrated activity by synergistic effect. Traditional has variety active components, including flavonoids, alkaloids, phenols, quinones, can inhibit growth drug-resistant be used combination antibiotics treat various bacterial infections. We reviewed interaction between ingredients antibiotic-resistant bacteria. At present, flavonoids alkaloids are been most widely studied, against show its antimicrobial on bacteria, enhance susceptibility potentially reduce required dosage rate Our results provide direction for finding developing alternative methods counteract offering new therapeutic strategy tackling

Язык: Английский

---

Potential of Seaweeds to Mitigate Production of Greenhouse Gases during Production of Ruminant Proteins

Global Challenges, Год журнала: 2023, Номер 7(5)

Опубликована: Апрель 8, 2023

Abstract The potential of seaweed to mitigate methane is real and studies with red seaweeds have found reductions in produced from ruminants fed the region 60–90% where active compound responsible for this bromoform. Other brown green observed production between 20 45% vitro 10% vivo. Benefits feeding are specific animal species‐dependent. In some instances, positive effects on milk performance selected while other note traits. A balance reducing maintaining health food quality necessary. Seaweeds a source essential amino acids minerals however, offer huge use as feeds maintenance once formulations doses correctly prepared administered. negative aspect feed currently cost associated wild harvest indeed aquaculture improvements must be made here if ingredients used solution control continued animal/ruminant sourced proteins future. This review collates information concerning different how they their constituents can reduce ensure sustainable ruminant an environmentally beneficial manner.

Язык: Английский

---

Anti-inflammatory activity of essential oil from medicinal plants: An insight into molecular mechanism, in-silico studies and signaling pathways

Phytomedicine, Год журнала: 2025, Номер 138, С. 156364 - 156364

Опубликована: Янв. 2, 2025

Язык: Английский

---

DU8ML: Machine Learning-Augmented Density Functional Theory Nuclear Magnetic Resonance Computations for High-Throughput In Silico Solution Structure Validation and Revision of Complex Alkaloids

The Journal of Organic Chemistry, Год журнала: 2022, Номер 87(7), С. 4818 - 4828

Опубликована: Март 18, 2022

Machine learning (ML) profoundly improves the accuracy of fast DU8+ hybrid density functional theory/parametric computations nuclear magnetic resonance spectra, allowing for high throughput in silico validation and revision complex alkaloids other natural products. Of nearly 170 surveyed, 35 structures are revised with next-generation ML-augmented DU8 method, termed DU8ML.

Язык: Английский

---