A Transdermal Drug Delivery System Based on Nucleic Acid Nanomaterials for Skin Photodamage Treatment DOI Open Access

Yu Xie,

Jiajun He,

Songhang Li

и другие.

Advanced Functional Materials, Год журнала: 2023, Номер 33(46)

Опубликована: Июль 9, 2023

Abstract Skin photodamage, which is induced by ultraviolet (UV) radiation, a prevalent cause of skin damage. In this study, transdermal drug delivery system developed for the topical treatment composed tetrahedral framework nucleic acids (tFNAs) and lipoic acid (LA). The tFNAs‐LA (TLA) nanocomposite exhibits excellent biocompatibility, as well antioxidant, anti‐apoptotic, anti‐inflammatory capabilities. tFNA, carrier, facilitates TLA cell entry penetration, while loaded LA enhances antioxidant photodamaged human dermal fibroblast (HDF), promotes proliferation migration inhibiting apoptosis activation reactive oxygen species production. Moreover, modulates apoptosis‐related proteins NF‐κB signaling pathways, increasing cellular secretion suppressing inflammatory responses in HDF cells. vivo experiment, application tissue healing skin, regulates expression inflammation collagen‐related proteins. It suggested that ability enables non‐invasive therapy highlighting potential employing acid‐based systems disease.

Язык: Английский

Environmental effects of ozone depletion, UV radiation and interactions with climate change: UNEP Environmental Effects Assessment Panel, update 2017 DOI
A. F. Bais, Robyn Lucas, Janet F. Bornman

и другие.

Photochemical & Photobiological Sciences, Год журнала: 2018, Номер 17(2), С. 127 - 179

Опубликована: Фев. 1, 2018

Язык: Английский

Процитировано

311

Ozone depletion, ultraviolet radiation, climate change and prospects for a sustainable future DOI
Paul W. Barnes, Craig E. Williamson, Robyn Lucas

и другие.

Nature Sustainability, Год журнала: 2019, Номер 2(7), С. 569 - 579

Опубликована: Июнь 24, 2019

Язык: Английский

Процитировано

280

Human health in relation to exposure to solar ultraviolet radiation under changing stratospheric ozone and climate DOI
Robyn Lucas, Seyhan Yazar, Antony R. Young

и другие.

Photochemical & Photobiological Sciences, Год журнала: 2019, Номер 18(3), С. 641 - 680

Опубликована: Фев. 27, 2019

Язык: Английский

Процитировано

193

Oxidation and fragmentation of plastics in a changing environment; from UV-radiation to biological degradation DOI Creative Commons
Anthony L. Andrady, Paul W. Barnes, Janet F. Bornman

и другие.

The Science of The Total Environment, Год журнала: 2022, Номер 851, С. 158022 - 158022

Опубликована: Авг. 12, 2022

Understanding the fate of plastics in environment is critical importance for quantitative assessment biological impacts plastic waste. Specially, there a need to analyze more detail reputed longevity context degradation through oxidation and fragmentation reactions. Photo-oxidation debris by solar UV radiation (UVR) makes material prone subsequent fragmentation. The fragments generated following exposure mechanical stresses include secondary micro- or nanoparticles, an emerging class pollutants. paper discusses UV-driven photo-oxidation process, identifying relevant knowledge gaps uncertainties. Serious exist concerning wavelength sensitivity dose-response photo-fragmentation process. Given heterogeneity natural irradiance varying from no sediments full floating, beach litter air-borne plastics, it argued that rates degradation/fragmentation will also vary dramatically between different locations environmental niches. Biological phenomena such as biofouling further modulate radiation, while potentially contributing and/or independent UVR. Reductions UVR many regions, consequent implementation Montreal Protocol its Amendments protecting stratospheric ozone, have consequences global heterogeneous manner across geographic zones. interacting effects warming, ozone are projected increase at surface localized areas, mainly because decreased cloud cover. complexity uncertainty future conditions, this currently precludes reliable predictions persistence on scale.

Язык: Английский

Процитировано

192

Environmental effects of stratospheric ozone depletion, UV radiation, and interactions with climate change: UNEP Environmental Effects Assessment Panel, Update 2020 DOI Creative Commons
Rachel Ε. Neale, Paul W. Barnes,

T. Matthew Robson

и другие.

Photochemical & Photobiological Sciences, Год журнала: 2021, Номер 20(1), С. 1 - 67

Опубликована: Янв. 1, 2021

Abstract This assessment by the Environmental Effects Assessment Panel (EEAP) of United Nations Environment Programme (UNEP) provides latest scientific update since our most recent comprehensive (Photochemical and Photobiological Sciences, 2019, 18, 595–828). The interactive effects between stratospheric ozone layer, solar ultraviolet (UV) radiation, climate change are presented within framework Montreal Protocol Sustainable Development Goals. We address how these global environmental changes affect atmosphere air quality; human health; terrestrial aquatic ecosystems; biogeochemical cycles; materials used in outdoor construction, energy technologies, fabrics. In many cases, there is a growing influence from seasonality extreme events due to change. Additionally, we assess transmission severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which responsible for COVID-19 pandemic, context linkages with UV radiation Protocol.

Язык: Английский

Процитировано

173

Fenton chemistry and reactive oxygen species in soil: Abiotic mechanisms of biotic processes, controls and consequences for carbon and nutrient cycling DOI
Guanghui Yu, Yakov Kuzyakov

Earth-Science Reviews, Год журнала: 2021, Номер 214, С. 103525 - 103525

Опубликована: Янв. 17, 2021

Язык: Английский

Процитировано

171

Linkages between stratospheric ozone, UV radiation and climate change and their implications for terrestrial ecosystems DOI
Janet F. Bornman, Paul W. Barnes,

T. Matthew Robson

и другие.

Photochemical & Photobiological Sciences, Год журнала: 2019, Номер 18(3), С. 681 - 716

Опубликована: Фев. 27, 2019

Язык: Английский

Процитировано

166

Impact of climate change and anthropogenic activities on aquatic ecosystem – A review DOI

Priya A. K,

M. Muruganandam,

Sivarethinamohan Rajamanickam

и другие.

Environmental Research, Год журнала: 2023, Номер 238, С. 117233 - 117233

Опубликована: Окт. 2, 2023

Язык: Английский

Процитировано

153

The interactive effects of stratospheric ozone depletion, UV radiation, and climate change on aquatic ecosystems DOI
Craig E. Williamson, Patrick J. Neale, Samuel Hylander

и другие.

Photochemical & Photobiological Sciences, Год журнала: 2019, Номер 18(3), С. 717 - 746

Опубликована: Фев. 27, 2019

Язык: Английский

Процитировано

151

Grape Berry Secondary Metabolites and Their Modulation by Abiotic Factors in a Climate Change Scenario–A Review DOI Creative Commons
Markus Rienth, Nicolas Vigneron, Philippe Darriet

и другие.

Frontiers in Plant Science, Год журнала: 2021, Номер 12

Опубликована: Март 22, 2021

Temperature, water, solar radiation, and atmospheric CO 2 concentration are the main abiotic factors that changing in course of global warming. These govern synthesis degradation primary (sugars, amino acids, organic etc.) secondary (phenolic volatile flavor compounds their precursors) metabolites directly, via regulation biosynthetic pathways, or indirectly, effects on vine physiology phenology. Several hundred have been identified grape berry. Their biosynthesis characterized shown to occur during different developmental stages The understanding how modulate metabolism thus berry quality is crucial importance for breeders growers develop plant material viticultural practices maintain high-quality fruit wine production context Here, we review berry, biosynthesis, accumulation influenced by factors. first part provides an update structure, phenolic (flavonoids non-flavonoids) major aroma (terpenes, thiols, methoxypyrazines, C13 norisoprenoids). second gives influence factors, such as water availability, temperature, concentration, metabolism. At end paper, raise some critical questions regarding intracluster heterogeneity dilution sampling strategy can impact outcome studies grapevine response

Язык: Английский

Процитировано

139