Advanced Functional Materials,
Год журнала:
2023,
Номер
33(46)
Опубликована: Июль 9, 2023
Abstract
Skin
photodamage,
which
is
induced
by
ultraviolet
(UV)
radiation,
a
prevalent
cause
of
skin
damage.
In
this
study,
transdermal
drug
delivery
system
developed
for
the
topical
treatment
composed
tetrahedral
framework
nucleic
acids
(tFNAs)
and
lipoic
acid
(LA).
The
tFNAs‐LA
(TLA)
nanocomposite
exhibits
excellent
biocompatibility,
as
well
antioxidant,
anti‐apoptotic,
anti‐inflammatory
capabilities.
tFNA,
carrier,
facilitates
TLA
cell
entry
penetration,
while
loaded
LA
enhances
antioxidant
photodamaged
human
dermal
fibroblast
(HDF),
promotes
proliferation
migration
inhibiting
apoptosis
activation
reactive
oxygen
species
production.
Moreover,
modulates
apoptosis‐related
proteins
NF‐κB
signaling
pathways,
increasing
cellular
secretion
suppressing
inflammatory
responses
in
HDF
cells.
vivo
experiment,
application
tissue
healing
skin,
regulates
expression
inflammation
collagen‐related
proteins.
It
suggested
that
ability
enables
non‐invasive
therapy
highlighting
potential
employing
acid‐based
systems
disease.
Frontiers in Oncology,
Год журнала:
2022,
Номер
12
Опубликована: Март 10, 2022
Solar
ultraviolet
(UV)
radiation
exposure
is
the
primary
etiological
agent
responsible
for
developing
cutaneous
malignancies.
Avoiding
excessive
exposure,
especially
by
high-risk
groups,
recommended
to
prevent
UV-induced
photo-pathologies.
However,
optimal
sun
essential
healthy
synthesis
of
about
90%
vitamin
D
levels
in
body.
Insufficient
UV-B
linked
deficiency
humans.
Therefore,
necessary
maintaining
a
normal
state
homeostasis
skin.
Humans
worldwide
face
major
existential
threat
because
climate
change
which
has
already
shown
its
effects
several
ways.
Over
last
4
5
decades,
increased
incidences
skin
cancer
cases
have
led
international
health
organizations
develop
strong
protection
measures.
at
same
time,
growing
concern
creating
kind
dilemma.
Current
knowledge
UV
outweighs
adverse
than
beneficial
roles
it
offers
body,
necessitating
correct
public
recommendation
on
exposure.
Following
an
appropriate
will
lead
positive
outcomes
protecting
humans
against
strict
recommendations
In
this
short
review,
we
spotlight
ambivalent
and
how
ozone
layer
depletion
influenced
these
UVR.
Further,
our
aim
remains
explore
towards
balanced
measures
spurt
diseases
due
inadequate
UV-B.
Environmental Chemistry Letters,
Год журнала:
2023,
Номер
22(1), С. 273 - 295
Опубликована: Сен. 15, 2023
Abstract
Skin
exposure
to
solar
ultraviolet
radiation
and
pollutants
causes
several
skin
disorders,
calling
for
protection
methods
such
as
sunscreen
application.
However,
common
contains
chemicals
that
have
displayed
toxicity
when
exposed
radiation.
Therefore,
alternatives
approaches
been
recently
developed,
the
use
of
natural
phytochemicals
active
ingredients
in
photoprotection
preparations.
Here,
we
review
with
focus
on
physics
by
filters.
We
present
sensors
measuring
ecosystems.
discuss
phototoxicity
drugs,
preservatives,
personal
care
products,
pollutants.
Photocarcinogenesis,
photoallergy,
photostability,
their
impacts
human
health
skin,
are
also
reviewed.
observed
promising
due
ability
absorb
photon
energy,
thus
act
antioxidants.
Nature Climate Change,
Год журнала:
2023,
Номер
13(6), С. 554 - 560
Опубликована: Май 25, 2023
Abstract
In
contrast
to
the
general
stratospheric
ozone
recovery
following
international
agreements,
recent
observations
show
an
ongoing
net
depletion
in
tropical
lower
stratosphere
(LS).
This
is
thought
be
driven
by
dynamical
transport
accelerated
global
warming,
while
chemical
processes
have
been
considered
unimportant.
Here
we
use
a
chemistry–climate
model
demonstrate
that
halogenated
ozone-depleting
very
short-lived
substances
(VSLS)
chemistry
may
account
for
around
quarter
of
observed
LS
negative
trend
1998–2018.
VSLS
sources
include
both
natural
and
anthropogenic
emissions.
Future
projections
persistence
currently
unaccounted
contribution
loss
throughout
twenty-first
century
LS,
only
region
not
projecting
2100.
Our
results
need
mitigation
strategies
emissions
preserve
present
future
layer
low
latitudes.
Advanced Functional Materials,
Год журнала:
2023,
Номер
33(46)
Опубликована: Июль 9, 2023
Abstract
Skin
photodamage,
which
is
induced
by
ultraviolet
(UV)
radiation,
a
prevalent
cause
of
skin
damage.
In
this
study,
transdermal
drug
delivery
system
developed
for
the
topical
treatment
composed
tetrahedral
framework
nucleic
acids
(tFNAs)
and
lipoic
acid
(LA).
The
tFNAs‐LA
(TLA)
nanocomposite
exhibits
excellent
biocompatibility,
as
well
antioxidant,
anti‐apoptotic,
anti‐inflammatory
capabilities.
tFNA,
carrier,
facilitates
TLA
cell
entry
penetration,
while
loaded
LA
enhances
antioxidant
photodamaged
human
dermal
fibroblast
(HDF),
promotes
proliferation
migration
inhibiting
apoptosis
activation
reactive
oxygen
species
production.
Moreover,
modulates
apoptosis‐related
proteins
NF‐κB
signaling
pathways,
increasing
cellular
secretion
suppressing
inflammatory
responses
in
HDF
cells.
vivo
experiment,
application
tissue
healing
skin,
regulates
expression
inflammation
collagen‐related
proteins.
It
suggested
that
ability
enables
non‐invasive
therapy
highlighting
potential
employing
acid‐based
systems
disease.
