Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(15), С. 3746 - 3751
Опубликована: Янв. 1, 2023
Synthesis of 2-amino substituted benzo- and naphtho-furans via [4 + 1] cycloaddition 2-hydroxy-substituted p -QMs various alkyl/aryl isocyanides has been achieved by using Sc(OTf) 3 as the catalyst.
Язык: Английский
Organic Letters, Год журнала: 2022, Номер 24(42), С. 7790 - 7795
Опубликована: Окт. 14, 2022
We have developed an efficient protocol for the construction of polycyclic dihydrobenzofuran spirooxindole scaffolds via base promoted cascade annulation Morita-Baylis-Hillman (MBH) carbonates isatins with ortho-hydroxychalcones or ortho-hydroxy-β-nitrostyrenes. The complex compounds were conveniently synthesized in satisfactory yields and high diastereoselectivity. This provides a swift convenient approach assembly diverse highly functionalized spirooxindoles also features broad substrate scope, molecular convergence, excellent atomic economy.
Язык: Английский
Процитировано
26
New Journal of Chemistry, Год журнала: 2023, Номер 47(26), С. 12274 - 12278
Опубликована: Янв. 1, 2023
A wide variety of isocoumarin derivatives are easily constructed via a Rh( iii )-catalyzed C–H bond activation/annulation cascade reaction.
Язык: Английский
Процитировано
15
Tetrahedron, Год журнала: 2023, Номер 148, С. 133655 - 133655
Опубликована: Окт. 9, 2023
Язык: Английский
Процитировано
15
Organic Chemistry Frontiers, Год журнала: 2019, Номер 6(22), С. 3799 - 3803
Опубликована: Янв. 1, 2019
A
practical
and
scalable
method
for
highly
stereoselective
construction
of
spiro-2,3-dihydrobenzofurans
Язык: Английский
Процитировано
37
The Journal of Organic Chemistry, Год журнала: 2020, Номер 85(17), С. 11240 - 11249
Опубликована: Авг. 11, 2020
An organocatalytic domino aza/oxa-Michael/1,6-addition reaction of ortho-tosylaminophenyl or ortho-hydroxyphenyl-substituted para-quinone methides and ynals has been developed. In the presence 20 mol % morpholine, this unprecedented cascade occurs readily in good yield (up to 99%), providing a highly efficient synthetic approach synthetically valuable 1,4-dihydroquinolines 4H-chromenes.
Язык: Английский
Процитировано
34
Green Chemistry, Год журнала: 2019, Номер 21(3), С. 675 - 683
Опубликована: Янв. 1, 2019
A
new
and
environmentally
benign
protocol
aimed
at
the
generation
of
triarylated
(
Язык: Английский
Процитировано
31
Organic Letters, Год журнала: 2019, Номер 21(19), С. 8008 - 8012
Опубликована: Сен. 19, 2019
An efficient synthesis of functionalized benzofurans is achieved under mild and metal-free conditions from stable para-quinone methides by treatment with phosphine, acyl chloride, a base. This one-pot phospha-1,6-addition/O-acylation/Wittig reaction also demonstrated catalytic similar efficacy.
Язык: Английский
Процитировано
31
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(21), С. 15472 - 15489
Опубликована: Окт. 15, 2024
We have developed a convenient synthetic protocol for efficient construction of significant dihydrobenzofuran and benzofuran scaffolds by Lewis base-mediated annulation reaction ortho-iminophenols ortho-vinylphenols with MBH carbonates isatins under mild metal-free conditions. The selective generation different kinds derivatives was successfully achieved employing substituted isatin-derived ortho-N-tosyliminophenols ortho-vinylphenols. features included broad substrate scopes, excellent functional group compatibility, high molecular diversity, atomic economy.
Язык: Английский
Процитировано
4
European Journal of Organic Chemistry, Год журнала: 2020, Номер 2020(31), С. 4988 - 4994
Опубликована: Июнь 24, 2020
A spirocyclopropanation of para ‐quinone methides with 3‐chlorooxindoles that proceeds via cascade 1,6‐conjugate addition/dearomatization reaction has been established, leading to a novel class bis‐spiro compounds in concise, rapid, and practical manner. This transformation could be completed high yields at room temperature within 5 min. The resulting cyclopropane derivatives are great interest because their potential biological activity further potential.
Язык: Английский
Процитировано
26
European Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Март 17, 2025
Abstract An efficient and operational [4+1] annulation strategy toward functional dihydrobenzofurans from 2‐bromomalonates in situ generated alkynyl o ‐quinone methides (from ‐hydroxyphenyl propargylamines) has been developed. Without the need for pre‐dried solvent inert atmosphere protection, a broad range of substituted propargylamines are well‐tolerated, producing expected alkynyl/carboxylated with good to high yields. Furthermore, gram‐scale synthesis valuable alkenyl/carboxylated construction were conducted provide great potential value medicinal chemistry other related disciplines.
Язык: Английский
Процитировано
0