Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 1 - 17
Опубликована: Янв. 1, 2024
Язык: Английский
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 1 - 17
Опубликована: Янв. 1, 2024
Язык: Английский
The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(16), С. 11562 - 11580
Опубликована: Июль 27, 2023
Diverse functionalized dihydrobenzofuran spiro-indanedione-oxindole scaffolds were conveniently synthesized by base-promoted cyclization reaction of Morita-Baylis-Hillman (MBH) carbonates isatins and 2-(o-hydroxybenzylidene)-1,3-indanediones. The two diastereomeric dispiro[indene-2,1'-cyclopenta[b]benzofuran-2',3″'-indolines] could be selectively using DABCO or DMAP as a base promoter. More importantly, facilitated the annulation MBH formates 2-(o-hydroxybenzylidene)-1,3-indanediones selectively, resulting in spiro[cyclopropa[c]chromene-1,2'-indene]-1',3'-diones dispiro[indene-2,1'-cyclopenta[b]benzofuran-2',3″'-indolines]. Additionally, similar with maleimides afforded dispiro[indene-2,5'-benzofuro[2',3':1,5]cyclopenta[1,2-c]pyrrole-4',3″'-indolines] high yields diastereoselectivity.
Язык: Английский
Процитировано
23Organic Chemistry Frontiers, Год журнала: 2022, Номер 10(2), С. 540 - 547
Опубликована: Дек. 10, 2022
An efficient synthetic protocol for the selective construction of spiro[indoline-3,5′-pyrrolo[3,4- b ]azepines] and spiro[indoline-3,3′-pyrroles] via a cycloaddition reaction α,β-unsaturated aldimines MBH adducts isatins was successfully developed.
Язык: Английский
Процитировано
24Journal of Molecular Structure, Год журнала: 2024, Номер 1304, С. 137684 - 137684
Опубликована: Фев. 4, 2024
Язык: Английский
Процитировано
5The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(24), С. 17181 - 17196
Опубликована: Ноя. 28, 2023
A convenient synthetic protocol for regioselective and diastereoselective construction of complex dispiro-indanone-fluorenone-oxindole motifs was developed by the base-promoted annulation reaction bindone MBH carbonates isatins adjusting conditions. DABCO promoted in DCM at room temperature, affording dispiro[indene-2,4′-fluorene-1′,3″-indoline] derivatives good yields with high diastereoselectivity. Triethylamine two molecular 1,3-indanediones esters ethanol elevated temperature selectively gave dispiro[indene-2,4′-fluorene-3′,3″-indolines] moderate yields. However, triethylamine excess refluxing ethanol, Z-isomer as major product E-isomer minor product.
Язык: Английский
Процитировано
12The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(15), С. 10854 - 10866
Опубликована: Июль 12, 2024
A convenient synthetic protocol for diverse fused chromenes was successfully developed by a three-component reaction of alkyl isocyanides, dialkyl but-2-ynedioates, and various cyclic 1,3-dipolarophiles containing
Язык: Английский
Процитировано
4The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(21), С. 15472 - 15489
Опубликована: Окт. 15, 2024
We have developed a convenient synthetic protocol for efficient construction of significant dihydrobenzofuran and benzofuran scaffolds by Lewis base-mediated annulation reaction ortho-iminophenols ortho-vinylphenols with MBH carbonates isatins under mild metal-free conditions. The selective generation different kinds derivatives was successfully achieved employing substituted isatin-derived ortho-N-tosyliminophenols ortho-vinylphenols. features included broad substrate scopes, excellent functional group compatibility, high molecular diversity, atomic economy.
Язык: Английский
Процитировано
4Organic Letters, Год журнала: 2023, Номер 25(47), С. 8445 - 8450
Опубликована: Ноя. 17, 2023
Despite the widespread presence of chiral cyclopentane motif, asymmetric synthesis cyclopentanes containing five stereocenters remains a formidable challenge. Here, we present an N-heterocyclic carbene (NHC)-catalyzed cascade reaction enal and oxindole-dienone, which allows access to spiroxindole featuring complete set centers on five-membered carbocycle. This strategy, characterized by formation multiple bonds centers, demonstrates broad substrate scope, exclusive diastereoselectivity, up 99:1 er.
Язык: Английский
Процитировано
10Tetrahedron Letters, Год журнала: 2025, Номер 156, С. 155455 - 155455
Опубликована: Янв. 8, 2025
Язык: Английский
Процитировано
0Tetrahedron Letters, Год журнала: 2025, Номер 156, С. 155452 - 155452
Опубликована: Янв. 13, 2025
Язык: Английский
Процитировано
0ChemistrySelect, Год журнала: 2025, Номер 10(4)
Опубликована: Янв. 1, 2025
Abstract A convenient synthetic protocol for novel spiro[indoline‐3,2′‐pyrrolo[2,1‐ a ]isoquinoline] and spiro[indoline‐3,2′‐pyrrolo[1,2‐ ]quinoline] motifs was successfully developed by three‐component reaction of isoquinoline (quinoline), cyclohexyl isocyanide, isatylidene malononitriles. In the absence any catalyst, isoquinoline, malononitriles in refluxing dichloromethane gave functionalized ]isoquinolines] good yields with high diastereoselectivity. However, similar quinoline afforded ]quinolines] about 2:1
Язык: Английский
Процитировано
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