A comprehensive review on the applications of nano-biosensor-based approaches for non-communicable and communicable disease detection

Biomaterials Science, Год журнала: 2021, Номер 9(10), С. 3576 - 3602

Опубликована: Янв. 1, 2021

The outstretched applications of biosensors in diverse domains has become the reason for their attraction scientific communities. Because they are analytical devices, can detect both quantitative and qualitative biological components through generation detectable signals. In recent past, witnessed significant changes developments design as well features. Nanotechnology revolutionized sensing phenomena by increasing biodiagnostic capacity terms specificity, size, cost, resulting exceptional sensitivity flexibility. steep increase non-communicable diseases across world emerged a matter concern. parallel, abrupt outbreak communicable poses serious threat to mankind. For decreasing morbidity mortality associated with various diseases, early detection subsequent treatment indispensable. Detection different markers generates quantifiable signals that be electrochemical, mass-based, optical, thermal, or piezoelectric. Speculating on incumbent applicability versatility nano-biosensors large disciplines, this review highlights types along mechanisms. Moreover, it deals current advancements made future prospects diagnostics.

Язык: Английский

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Nanotechnology from lab to industry – a look at current trends

Nanoscale Advances, Год журнала: 2022, Номер 4(18), С. 3664 - 3675

Опубликована: Янв. 1, 2022

Nanotechnology holds great promise and is hyped by many as the next industrial evolution. Medicine, food cosmetics, agriculture environmental health, technology industries already profit from nanotechnology innovations their influence expected to increase drastically in near future. However, there are also challenges that need be overcome bring a nanotechnological product or business market. In this article we discuss current examples of have been successfully introduced market relevance geographical spread. We then different partners for scientists role commercialization process. Finally, review steps it takes market, highlight difficulties related these steps, provide roadmap journey lab industry which can beneficial researchers.

Язык: Английский

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Disposable biosensors based on metal nanoparticles

Sensors International, Год журнала: 2022, Номер 3, С. 100169 - 100169

Опубликована: Янв. 1, 2022

The coronavirus disease2019 (COVID-19) pandemic has highlighted the need for disposable biosensors that can detect viruses in infected patients quickly due to fast response and also at a low cost.The present review provides an overview of applications based on metal nanoparticles enzymatic non-enzymatic sensors with special reference glucose H2O2, immunosensors as well genosensors (DNA which recognized event consists hybridization reaction)for point-of-care diagnostics. COVID19 have been discussed.

Язык: Английский

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Bioinspired Multifunctional Silver Nanoparticles for Optical Sensing Applications: A Sustainable Approach

ACS Applied Bio Materials, Год журнала: 2023, Номер 6(11), С. 4549 - 4571

Опубликована: Окт. 18, 2023

Silver nanoparticles developed via biosynthesis are the most fascinating nanosized particles and encompassed with excellent physicochemical properties. The bioinspired different shapes sizes have attracted huge attention due to their stability, low cost, environmental friendliness, use of less hazardous chemicals. This is an ideal method for synthesizing a range metal from plants biomolecules. Optical biosensors progressively being fabricated attainment sustainability by using opportunities offered nanotechnology. review focuses mainly on tuning optical properties sensing explore importance applications silver nanoparticles. Further, this deliberates role (Ag NPs) in biomedical, agricultural, environmental, energy applications. Profound insight into antimicrobial these also appreciated. Tailor-made effectuating characteristics can unsurprisingly target tumor cells distribute enwrapped payloads intensively. Existing challenges prospects Ag NPs summarized. expected deliver perceptions about progress next generation outstanding performances various fields promoting sustainable practices fabricating devices.

Язык: Английский

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Emerging Applications of Nanobiosensors in Pathogen Detection in Water and Food

Biosensors, Год журнала: 2023, Номер 13(10), С. 922 - 922

Опубликована: Окт. 11, 2023

Food and waterborne illnesses are still a major concern in health food safety areas. Every year, almost 0.42 million 2.2 deaths related to illness reported worldwide, respectively. In foodborne pathogens, bacteria such as Salmonella, Shiga-toxin producer Escherichia coli, Campylobacter, Listeria monocytogenes considered be high-concern pathogens. High-concern pathogens Vibrio cholerae, leptospirosis, Schistosoma mansoni, Schistosima japonicum, among others. Despite the efforts of water quality control monitor presence these kinds sources, occurrence is high globally. For reasons, development novel faster pathogen-detection methods applicable real-time surveillance strategies required. Methods based on biosensor devices have emerged tools for detection contrast traditional that usually time-consuming unsuitable large-scale monitoring. Biosensor can summarized use biochemical reactions with biorecognition section (isolated enzymes, antibodies, tissues, genetic materials, or aptamers) detect most cases, biosensors correlation electrical, thermal, optical signals pathogen biomarkers. The application nano molecular technologies allows identification high-sensibility manner, at extremely low-pathogen concentrations. fact, integration gold, silver, iron, magnetic nanoparticles (NP) has demonstrated an improvement their functionality. present review summarizes principal nanomaterials biosensor-based samples. Additionally, it highlights through nanomaterials. Nanomaterials offer unique advantages detection. nanoscale specific surface area more effective interaction pathogenic agents, enhancing sensitivity selectivity biosensors. Finally, biosensors’ capability functionalize molecules antibodies nucleic acids facilitates target

Язык: Английский

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Increasing the sensitivity and accuracy of detecting exosomes as biomarkers for cancer monitoring using optical nanobiosensors

Cancer Cell International, Год журнала: 2024, Номер 24(1)

Опубликована: Май 30, 2024

Abstract The advancement of nanoscience and material design in recent times has facilitated the creation point-of-care devices for cancer diagnosis biomolecule sensing. Exosomes (EXOs) facilitate transfer bioactive molecules between cells diverse local distant microenvironments, thereby contributing to progression metastasis. Specifically, EXOs derived from are likely function as biomarkers early detection due genetic or signaling alterations they transport payload within origin. It been verified that circulate steadily bodily secretions contain a variety information indicates tumor. However, acquiring molecular interactions regarding presented significant technical challenges their nanoscale nature high heterogeneity. Colorimetry, surface plasmon resonance (SPR), fluorescence, Raman scattering examples optical techniques utilized quantify exosomal biomarkers, including lipids, proteins, RNA, DNA. Many optically active nanoparticles (NPs), predominantly carbon-based, inorganic, organic, composite-based nanomaterials, have employed biosensing technology. exceptional physical properties exhibited by carbon NPs, noble metal magnetic progress development nanobiosensors intended originating tumors. Following summary biogenesis, biological functions, biomarker value known EXOs, this article provides an update on methodologies currently under investigation. In conclusion, we propose some potential enhancements biosensors detecting EXO, utilizing various NP materials such silicon graphene oxide (GO), quantum dots (QDs).

Язык: Английский

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Nanotechnology's role in ensuring food safety and security

Biocatalysis and Agricultural Biotechnology, Год журнала: 2024, Номер 58, С. 103220 - 103220

Опубликована: Май 14, 2024

Язык: Английский

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Review of Noble Metal Nanoparticle-Based Colorimetric Sensors for Food Safety Monitoring

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(17), С. 19821 - 19853

Опубликована: Авг. 16, 2024

Food safety, particularly concerning foods contaminated by toxic chemicals, has emerged as a pervasive societal concern. The prevalence of food contaminants spurred both scientific communities and industries to develop highly sensitive selective sensors for rapid precise authentication. Noble metal nanoparticles (NPs) have garnered significant attention in this regard due their exceptional properties, including high sensitivity, selectivity, stability, target binding affinity, versatility modification detect specific contaminants. Moreover, the readout such is relatively straightforward, resulting color change can be observed with naked eye. This Review aims delve into current strategies involving various noble NPs colorimetric nanosensors safety monitoring applications. It begins elucidating working principles, encompassing localized surface plasmon resonance (LSPR), enzyme-based approaches, other methodologies. Subsequently, material properties commonly utilized NPs, those gold, silver, palladium, platinum, copper, are meticulously examined, providing comprehensive overviews benefits drawbacks associated each material. Furthermore, summarizes latest use cases diverse applications, ranging from detection heavy veterinary pesticide drug residues foodborne pathogens. Lastly, it addresses remaining challenges field proposes feasible solutions, offering insights future research directions.

Язык: Английский

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Applications of microfluidics in biosensing

Deleted Journal, Год журнала: 2024, Номер 6(6)

Опубликована: Май 31, 2024

Abstract Microfluidic devices have become a vastly popular technology, particularly because of the advantages they offer over their traditional counterparts. They such wide range uses and can make complex tasks quite efficient. One area research or work that has benefited greatly from use microfluidics is biosensing, where microfluidic chips are integrated into biosensor setups. There growing numbers applications in this as researchers look for efficient ways to tackle disease diagnostics drug discovery, which critical era recurring pandemics. In work, authors review integration with biosensors, well food security, molecular biology, cell diagnostics, at some most recent these areas. The covers including cellular life science research, agro-food processing, immunological veterinarian diagnostics. Microfluidics field combines fundamental laws physics chemistry solve miniaturization problems involving fluids nanoscale microscale, such, also examine mathematical concepts biosensing. relatively new technologies great potential terms applications.

Язык: Английский

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Ag‐Cu Nanoarchitecture for Enhanced LSPR Absorption: the Role of Surface Roughness and near‐field Interactions

Advanced Materials Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Abstract The plasmonic properties and biosensing performance of a nanocomposite with incorporated Cu Ag nanoparticles (NPs) are studied experimentally. concept's viability is verified by detecting specific anti‐decorin‐binding protein A (DbpA) from Borrelia afzelii antibodies, typically produced living organism in response to Lyme disease infection, carried out real‐life negative positive blood sera. It shown that the addition NPs on top silver regularly boosts absorption caused optical electrical changes vicinity surface compared only. Finite‐difference time‐domain (FDTD) simulations near‐field interaction different environments propose suitable Cu–Ag coupling modes responsible for modulation localized Surface Plasmon Resonance (LSPR) bands. Furthermore, increased roughness, resulting architecture combined metals, significantly enlarges effective area sensing applications, which consequentially leads better species immobilization. observed distinguishable differences between sera LSPR response, high sensitivity selectivity together stability (suppressed aging) opens door concepts rapid, low‐cost, sensitive LPSR‐based biodetection platforms.

Язык: Английский

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