Chemistry - A European Journal,
Год журнала:
2020,
Номер
27(10), С. 3213 - 3228
Опубликована: Июль 7, 2020
Abstract
Owing
to
their
non‐toxic,
stable,
inexpensive
properties,
carboxylic
acids
are
considered
as
environmentally
benign
alternatives
coupling
partners
in
various
organic
transformations.
Electrochemical
mediated
decarboxylation
of
acid
has
emerged
a
new
and
efficient
methodology
for
the
construction
carbon‐carbon
or
carbon‐heteroatom
bonds.
Compared
with
transition‐metal
catalysis
photoredox
catalysis,
electro‐organic
decarboxylative
transformations
green
sustainable
protocol
due
absence
chemical
oxidants
strong
bases.
Further,
it
exhibits
good
tolerance
functional
groups.
In
this
Minireview,
we
summarize
recent
advances
discoveries
on
electrochemical
C−C
C−heteroatoms
bond
formations.
The Chemical Record,
Год журнала:
2021,
Номер
21(9), С. 2574 - 2584
Опубликована: Апрель 9, 2021
Abstract
Electroorganic
synthesis
has
recently
become
a
rapidly
blossoming
research
area
within
the
organic
community.
It
should
be
noted
that
electrochemical
reaction
is
always
balanced
system
with
two
half‐cell
reactions‐oxidation
and
reduction.
Most
strategies,
however,
typically
focus
on
one
of
sides
for
desired
transformations.
Paired
electrolysis
desirable
half
reactions
running
simultaneously,
thus
maximizing
overall
margin
atom
energy
economy.
Meanwhile,
spatial
separation
between
oxidation
reduction
essential
feature
electrochemistry,
offering
unique
opportunities
development
redox‐neutral
would
otherwise
challenging
to
accomplish
in
conventional
flask
setting.
This
review
discusses
most
recent
illustrative
examples
paired
special
emphasis
sequential
convergent
processes.
Organic Letters,
Год журнала:
2024,
Номер
26(34), С. 7227 - 7232
Опубликована: Авг. 20, 2024
We
present
an
electrochemical
alkylation
of
azauracils
using
N-(acyloxy)phthalimides
(NHPI
esters)
as
readily
available
alkyl
radical
progenitors
under
metal-
and
additive-free
conditions.
Several
are
shown
to
undergo
with
array
NHPI
esters
(1°,
2°,
3°,
sterically
congested),
providing
the
desired
products
in
good
excellent
yields.
This
operationally
simple
method
is
robust,
scalable,
suitable
for
both
batch
flow
setups.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 28, 2025
Abstract
Motivated
by
the
inherent
benefits
of
synergistically
combining
electrochemical
methodologies
with
nickel
catalysis,
we
present
here
a
Ni-catalyzed
enantioselective
electroreductive
cross-coupling
benzyl
chlorides
aryl
halides,
yielding
chiral
1,1-diaryl
compounds
good
to
excellent
enantioselectivity.
This
catalytic
reaction
can
not
only
be
applied
chlorides/bromides,
which
are
challenging
access
other
means,
but
also
containing
silicon
groups.
Additionally,
absence
sacrificial
anode
lays
foundation
for
scalability.
The
combination
cyclic
voltammetry
analysis
electrode
potential
studies
suggests
that
Ni
I
species
activate
halides
via
oxidative
addition
and
alkyl
single
electron
transfer.
The Journal of Organic Chemistry,
Год журнала:
2021,
Номер
86(24), С. 17816 - 17832
Опубликована: Дек. 7, 2021
We
report
a
Minisci-type
cross-dehydrogenative
alkylation
in
an
aerobic
atmosphere
using
abundant
and
inexpensive
cerium
chloride
as
photocatalyst
air
oxidant.
This
photoreaction
exhibits
excellent
tolerance
to
functional
groups
is
suitable
for
both
heteroarene
alkane
substrates
under
mild
conditions,
generating
the
corresponding
products
moderate-to-good
yields.
Our
method
provides
alternative
approach
late-stage
functionalization
of
valuable
substrates.
ACS Organic & Inorganic Au,
Год журнала:
2021,
Номер
2(2), С. 126 - 147
Опубликована: Дек. 22, 2021
The
formation
of
C(sp3)–C(sp3)
and
C(sp3)–C(sp2)
bonds
is
one
the
major
research
goals
synthetic
chemists.
Electrochemistry
commonly
considered
to
be
an
appealing
means
drive
redox
reactions
in
a
safe
sustainable
fashion
has
been
utilized
for
C–C
bond-forming
reactions.
Compared
anodic
oxidative
methods,
which
have
extensively
explored,
cathodic
processes
are
much
less
investigated,
whereas
it
can
pave
way
alternative
retrosynthetic
disconnections
target
molecules
discovery
new
transformations.
This
review
provides
overview
on
recent
achievements
construction
via
since
2017.
It
includes
electrochemical
reductions
convergent
paired
electrolyses.
Green Chemistry,
Год журнала:
2021,
Номер
24(2), С. 858 - 863
Опубликована: Дек. 13, 2021
A
visible-light-mediated
direct
C3-alkylation
of
quinoxalin-2(1
H
)-ones
and
coumarins
with
unactivated
alkyl
iodides
under
metal-
external
photocatalyst-free
conditions
is
described.
Asian Journal of Organic Chemistry,
Год журнала:
2023,
Номер
12(2)
Опубликована: Янв. 11, 2023
Abstract
We
developed
a
novel
and
efficient
method
for
the
synthesis
of
various
3‐alkylated
quinoxalin‐2(1
H
)‐ones
(32
examples,
70%–96%
yields)
through
electron
donor‐acceptor
complex
enabled
alkylation
with
N
‐
hydroxyphthalimide
esters
as
alkyl
source
Na
2
S
catalytic
donor
under
external
photocatalyst‐,
oxidant‐
additive‐free
conditions.
