Catalytically Active CoFe₂O₄ Nanoflowers for Augmented Sonodynamic and Chemodynamic Combination Therapy with Elicitation of Robust Immune Response

ACS Nano, Год журнала: 2021, Номер 15(7), С. 11953 - 11969

Опубликована: Июнь 18, 2021

A hypoxic and acidic tumor microenvironment (TME) plays a significant role in cancer development through complex cellular signaling networks, it is thus challenging to completely eradicate tumors via monotherapy. Here, PEGylated CoFe2O4 nanoflowers (CFP) with multiple enzymatic activities, serving as bioreactors responsive TME cues, were synthesized typical solvothermal method for augmented sonodynamic therapy (SDT) chemodynamic (CDT) elicitation of robust immune response. The CFP occupying multivalent elements (Co2+/3+, Fe2+/3+) exhibited strong Fenton-like catalase-like activity. In another aspect, itself brand-new sonosensitizer high-performance SDT based on ultrasound-triggered electron (e–)/hole (h+) pair separation from the energy band promptness high efficiency. With efficient enrichment tumorous tissue revealed by magnetic resonance imaging, CPF could generate •OH CDT relying reactions. Moreover, catalase-mimicking react endogenous H2O2 molecular oxygen, O2 level may promote production 1O2 SDT. What's more, reactive oxygen species obtained combined SDT/CDT efficiently trigger immunogenic cell death synergistic antitumor immunity aid an checkpoint blockade sake suppressing primary distant well lung metastasis. Taken together, this paradigm delivers useful insights developing in-coming nanocomposites cobalt ferrite theranostics.

Язык: Английский

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Nanoscale porous organic polymers for drug delivery and advanced cancer theranostics

Chemical Society Reviews, Год журнала: 2021, Номер 50(23), С. 12883 - 12896

Опубликована: Янв. 1, 2021

Finding a personalized nano theranostics solution, nanomedicine for cancer diagnosis and therapy, is among the top challenges of current medicinal science. Porous organic polymers (POPs) are permanent porous materials prepared by linking relatively rigid multidimensional building blocks. POP nanoparticles have remarkable advantage owing to their specific physicochemical characteristics such as high surface area, convincing pore size engineering, stimuli-responsive degradability, negligible toxicity, open covalent post-synthesis modification possibilities etc. POPs crystalline non-crystalline characteristics; popularly known frameworks (COFs), shown potential application across research areas in The early development on applications nanoscale has tremendous future clinical translation. This tutorial review highlights recently developed promising nPOPs drug loading, targeted delivery, endogenous exogenous release, imaging combination regardless poorly properties. will provide platform translation solving fundamental nanomedicines loading efficiency, size-optimization, biocompatibility, dispersibility cell uptake ability.

Язык: Английский

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Sonodynamic therapy-derived multimodal synergistic cancer therapy

Cancer Letters, Год журнала: 2020, Номер 497, С. 229 - 242

Опубликована: Окт. 27, 2020

Язык: Английский

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Stanene‐Based Nanosheets for β‐Elemene Delivery and Ultrasound‐Mediated Combination Cancer Therapy

Angewandte Chemie International Edition, Год журнала: 2021, Номер 60(13), С. 7155 - 7164

Опубликована: Янв. 15, 2021

Abstract Ultrasound (US)‐mediated sonodynamic therapy (SDT) has emerged as a superior modality for cancer treatment owing to the non‐invasiveness and high tissue‐penetrating depth. However, developing biocompatible nanomaterial‐based sonosensitizers with efficient SDT capability remains challenging. Here, we employed liquid‐phase exfoliation strategy obtain new type of two‐dimensional (2D) stanene‐based nanosheets (SnNSs) band gap 2.3 eV, which is narrower than those most extensively studied nano‐sonosensitizers, allowing more US‐triggered separation electron (e − )‐hole (h + ) pairs reactive oxygen species (ROS) generation. In addition, discovered that such SnNSs could also serve robust near‐infrared (NIR)‐mediated photothermal (PTT) agents their conversion, nanocarriers anticancer drug delivery inherent 2D layered structure. This study not only presents general nanoplatforms SDT‐enhanced combination therapy, but highlights utility field nanomedicine.

Язык: Английский

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Nanoplatform-based cascade engineering for cancer therapy

Chemical Society Reviews, Год журнала: 2020, Номер 49(24), С. 9057 - 9094

Опубликована: Янв. 1, 2020

This review provides a comprehensive overview of the recent advances in nanoplatform-based cascade engineering for cancer therapy, by concentrating on design smart nanoplatforms and implementation specific processes.

Язык: Английский

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