Chemodynamic
therapy
(CDT),
which
induces
cell
death
by
decomposing
high
levels
of
H2
O2
in
tumor
cells
into
highly
toxic
·OH,
is
recognized
as
a
promising
antineoplastic
approach.
However,
current
CDT
approaches
are
often
restricted
the
controlled
and
upregulated
cellular
antioxidant
defense.
To
enhance
·OH-induced
damage
CDT,
covalent
organic
framework
(COF)-based,
ferrocene
(Fc)-
glutathione
peroxidase
4
(GPX4)
inhibitor-loaded
nanodrug,
RSL3@COF-Fc
(2b),
fabricated.
The
obtained
2b
not
only
promotes
situ
Fenton-like
reactions
to
trigger
·OH
production
cells,
but
also
attenuates
repair
mechanisms
under
oxidative
stress
via
irreversible
GPX4
inhibition.
As
result,
these
two
synergistically
result
massive
lipid
peroxide
accumulation,
subsequent
damage,
ultimately
ferroptosis,
while
being
limited
intracellular
glutathione.
It
believed
that
this
research
provides
paradigm
for
enhancing
reactive
oxygen
species-mediated
oncotherapy
through
redox
dyshomeostasis
may
provide
new
insights
developing
COF-based
nanomedicine.
Chemical Reviews,
Год журнала:
2021,
Номер
122(1), С. 442 - 564
Опубликована: Дек. 1, 2021
Synthetic
chemists
have
developed
robust
methods
to
synthesize
discrete
molecules,
linear
and
branched
polymers,
disordered
cross-linked
networks.
However,
two-dimensional
polymers
(2DPs)
prepared
from
designed
monomers
been
long
missing
these
capabilities,
both
as
objects
of
chemical
synthesis
in
nature.
Recently,
new
polymerization
strategies
characterization
enabled
the
unambiguous
realization
covalently
linked
macromolecular
sheets.
Here
we
review
2DPs
2D
methods.
Three
predominant
emerged
date,
which
produce
either
monolayers
or
multilayer
assemblies.
We
discuss
fundamental
understanding
scope
each
approaches,
including:
bond-forming
reactions
used,
synthetic
diversity
prepared,
their
stacking
behaviors,
nanoscale
mesoscale
structures,
macroscale
morphologies.
Additionally,
describe
analytical
tools
currently
available
characterize
various
isolated
forms.
Finally,
emergent
2DP
properties
potential
applications
planar
macromolecules.
Throughout,
highlight
achievements
identify
opportunities
for
continued
study.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(15), С. 6307 - 6416
Опубликована: Янв. 1, 2022
This
review
highlights
the
recent
advances
of
metalated
covalent
organic
frameworks,
including
synthetic
strategies
and
applications,
discusses
current
challenges
future
directions.
Journal of the American Chemical Society,
Год журнала:
2022,
Номер
144(12), С. 5643 - 5652
Опубликована: Март 21, 2022
Developing
cost-/energy-efficient
separation
techniques
for
purifying
ethylene
from
an
ethylene/ethane
mixture
is
highly
important
but
very
challenging
in
the
industrial
process.
Herein,
using
a
bottom-up
[8
+
2]
construction
approach,
we
rationally
designed
and
synthesized
three
three-dimensional
covalent
organic
frameworks
(COFs)
with
8-connected
bcu
networks,
which
can
selectively
remove
ethane
high
efficiency.
These
COF
materials,
are
fabricated
by
condensation
reaction
of
customer-designed
octatopic
aldehyde
monomer
linear
diamino
linkers,
possess
crystallinity,
good
structural
robustness,
porosity.
Attributed
to
well-organized
micro-sized
pores
nonpolar/inert
pore
environment,
these
COFs
display
adsorption
capacity
selectivity
over
ethylene,
making
them
among
best
ethane-selective
adsorbents
purification.
Their
excellent
performance
validated
dynamic
breakthrough
experiments
high-purity
(>99.99%)
produced
through
single
The
surpasses
all
reported
C2H6-selective
even
some
benchmark
metal-organic
frameworks.
This
work
provides
guidance
design
new
value-added
gas
Chemical Society Reviews,
Год журнала:
2021,
Номер
50(20), С. 11381 - 11485
Опубликована: Янв. 1, 2021
To
date,
nanotechnology
has
increasingly
been
identified
as
a
promising
and
efficient
means
to
address
number
of
challenges
associated
with
public
health.
In
the
past
decade,
two-dimensional
(2D)
biomaterials,
unique
nanoplatform
planar
topology,
have
attracted
explosive
interest
in
various
fields
such
biomedicine
due
their
morphology,
physicochemical
properties
biological
effect.
Motivated
by
progress
graphene
biomedicine,
dozens
types
ultrathin
2D
biomaterials
found
versatile
bio-applications,
including
biosensing,
biomedical
imaging,
delivery
therapeutic
agents,
cancer
theranostics,
tissue
engineering,
well
others.
The
effective
utilization
stems
from
in-depth
knowledge
structure-property-bioactivity-biosafety-application-performance
relationships.
A
comprehensive
summary
for
is
still
lacking.
this
review,
we
aim
concentrate
on
state-of-the-art
particular
focus
applications.
particular,
discuss
design,
fabrication
functionalization
used
diverse
applications
based
up-to-date
progress.
Furthermore,
interactions
between
systems
spatial-temporal
scale
are
highlighted,
which
will
deepen
understanding
underlying
action
mechanism
aiding
design
improved
functionalities.
Finally,
taking
bench-to-bedside
focus,
conclude
review
proposing
current
crucial
issues/challenges
presenting
future
development
directions
advance
clinical
translation
these
emerging
biomaterials.
Advanced Materials,
Год журнала:
2021,
Номер
34(25)
Опубликована: Сен. 17, 2021
Covalent
organic
frameworks
(COFs)
are
promising
membrane
materials
due
to
their
high
porosity,
ordered
arrangements,
and
stability.
However,
the
relatively
large
pore
size
complicated
preparation
processes
of
COFs
limit
applications
in
sieving
small
gas
molecules,
even
at
a
lab
scale.
Herein,
multi-interfacial
engineering
strategy
is
proposed,
that
is,
direct
layer-by-layer
interfacial
reaction
two
(TpPa-SO3
H
TpTGCl
)
with
different
sizes
form
narrowed
apertures
COF-COF
interfaces
atop
large-pore
COF
(COF-LZU1)
film.
At
423
K,
one
fabricated
155
nm-thick
ultrathin
displays
H2
permeance
as
2163
permeation
units
(GPU)
/CO2
selectivity
26,
transcending
2008
Robeson
upper
bound.
This
not
only
provides
high-performance
candidates
for
separation,
but
also
enlightens
manipulation
other
COFs,
porous
polymers,
membranes.
Advanced Functional Materials,
Год журнала:
2020,
Номер
31(1)
Опубликована: Сен. 18, 2020
Abstract
Severe
disease
and
environmental
pollution
derived
from
heavy
metal
ions
has
become
one
of
the
major
problems
in
global
public
health.
In
particular,
mercury(II)
as
type
highly
poisonous
pollutant
can
destroy
human
metabolism,
central
nervous
system,
immune
representing
a
critical
threat
to
living
systems.
Therefore,
exploitation
new
strategies
for
designing
synthesizing
eco‐friendly,
efficient,
economical
materials
selective
detection
removal
Hg
2+
is
great
importance.
Among
various
measures
sensing,
detection,
mercury
ions,
advanced
functional
systems
including
nanomaterials,
polymers,
aggregation‐induced
emission
luminogens,
porous
have
attracted
considerable
attention
over
past
years
due
their
capabilities
real‐time
rapid
removal,
anti‐interference,
quick
response,
high
selectivity,
low
limit
detection.
this
review,
some
efficient
techniques
aqueous
solutions
using
abovementioned
are
overviewed
ways
which
these
material
used
tackle
problem
also
discussed.
