Bioengineering,
Год журнала:
2024,
Номер
11(5), С. 508 - 508
Опубликована: Май 17, 2024
Magnesium
(Mg)
is
considered
an
attractive
option
for
orthopedic
applications
due
to
its
density
and
elastic
modulus
close
the
natural
bone
of
body,
as
well
biodegradability
good
tensile
strength.
However,
it
faces
serious
challenges,
including
a
high
degradation
rate
and,
result,
loss
mechanical
properties
during
long
periods
exposure
biological
environment.
Also,
among
other
weaknesses,
can
be
mentioned
that
does
not
deal
with
bacterial
biofilms.
It
has
been
found
making
composites
by
synergizing
various
components
efficient
way
improve
properties.
Among
metal
oxide
nanoparticles,
magnesium
nanoparticles
(MgO
NPs)
have
distinct
physicochemical
properties,
biocompatibility,
biodegradability,
bioactivity,
significant
antibacterial
which
make
choice
reinforcement
in
composites.
lack
comprehensive
understanding
effectiveness
Mg
NPs
matrix
reinforcements
mechanical,
corrosion,
fields
challenge
their
application.
While
introducing
role
MgO
medical
fields,
this
article
summarizes
most
important
results
recent
research
on
performance
Mg/MgO
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(15), С. 6307 - 6416
Опубликована: Янв. 1, 2022
This
review
highlights
the
recent
advances
of
metalated
covalent
organic
frameworks,
including
synthetic
strategies
and
applications,
discusses
current
challenges
future
directions.
Chemical Physics Impact,
Год журнала:
2022,
Номер
5, С. 100091 - 100091
Опубликована: Июнь 28, 2022
Prostate
cancer
that
is
resistant
to
castration
has
been
a
prominent
health
challenge
in
the
lives
of
men,
particularly
older
men.
This
study
looks
at
spectroscopic
properties,
density
functional
theory
(DFT)
calculations,
and
molecular
docking
chemical
N-(1H-pyrrol-2-yl)
methylene)-4-methylaniline(PMMA)
order
see
if
it
can
be
used
as
chemotherapeutic
medication
for
treatment
castration-resistant
prostate
cancer(CRPC).
The
frontier
orbitals
(FMO),
Fukui
reactivity
functions,
non-linear
optics
(NLO),
natural
bond
(NBO)
were
investigated
further
using
DFT
6–311++G
(d,
p)
with
five
different
(B3LYP,
B3PW91,
ɷB97XD,
PBEPBE,
M06–2X)
investigation
studied
structural
properties.
experimental
theoretical
vibration
analysis
synthesized
molecule
employing
investigations
solvents
B3PW91/6–311++G
found
good
agreement.
results
three
proteins
(4XVE,
1XF0,
5Y8Y)
PMMA
showed
binding
affinities
when
compared
standard
drug
(Darolutamide)
(DLA).
indicated
have
an
excellent
potential
CRPC.
Covalent
organic
frameworks
(COFs)
stand
for
a
class
of
emerging
crystalline
porous
materials,
which
are
ingeniously
constructed
with
units
through
strong
covalent
bonds.
Their
excellent
design
capabilities,
and
uniform
tunable
pore
structure
make
them
potential
materials
various
applications.
With
the
continuous
development
synthesis
technique
nanoscience,
COFs
have
been
successfully
combined
variety
functional
to
form
COFs-based
composites
superior
performance
than
individual
components.
This
paper
offers
an
overview
different
types
reported
so
far,
particular
focus
on
applications
composites.
Moreover,
challenges
future
prospects
presented.
We
anticipate
that
review
will
provide
some
inspiration
further
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 15, 2024
Abstract
Nanotechnology
holds
immense
promise
in
revolutionising
healthcare,
offering
unprecedented
opportunities
diagnostics,
drug
delivery,
cancer
therapy,
and
combating
infectious
diseases.
This
review
explores
the
multifaceted
landscape
of
nanotechnology
healthcare
while
addressing
critical
aspects
safety
environmental
risks
associated
with
its
widespread
application.
Beginning
an
introduction
to
integration
we
first
delved
into
categorisation
various
materials
employed,
setting
stage
for
a
comprehensive
understanding
potential.
We
then
proceeded
elucidate
diverse
applications
nanotechnology,
spanning
medical
tissue
engineering,
targeted
gene
development
antimicrobial
agents.
The
discussion
extended
current
situation
surrounding
clinical
translation
commercialisation
these
cutting-edge
technologies,
focusing
on
nanotechnology-based
products
that
have
been
approved
globally
date.
also
discussed
considerations
nanomaterials,
both
terms
human
health
impact.
presented
vivo
nanomaterial
exposure,
relation
transport
mechanisms,
oxidative
stress,
physical
interactions.
Moreover,
highlighted
risks,
acknowledging
potential
implications
ecosystems
biodiversity.
Lastly,
strived
offer
insights
regulatory
governing
across
different
regions
globally.
By
synthesising
perspectives,
underscore
imperative
balancing
innovation
stewardship,
charting
path
forward
responsible
healthcare.
Graphical
abstract
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 19, 2024
Abstract
Colorectal
cancer,
the
third
most
prevalent
cancer
globally,
contributes
significantly
to
mortality
rates,
with
over
1.9
million
reported
cases
and
nearly
935,000
fatalities
annually.
Surgical
resection
is
a
primary
approach
for
localized
colorectal
tumors,
adjunct
therapies
like
chemotherapy,
radiotherapy,
targeted/immunotherapy
considered
depending
on
tumor
stage.
However,
despite
preferences
targeted
immunotherapy
post-surgery,
chemotherapy
remains
commonly
chosen
due
its
lower
cost
high
cancer-killing
efficiency.
Yet,
faces
issues
such
as
resistance
severe
side
effects.
Nanotechnology
has
emerged
in
therapy
by
alleviating
drawbacks
of
current
treatment
approaches.
In
past
few
decades,
inorganic
nanoparticles
have
shown
promise
combating
offering
advantages
conventional
chemotherapy.
Compared
organic
nanoparticles,
exhibit
properties
photosensitivity,
conductivity,
magnetic
allure,
thermal
proficiency,
allowing
them
function
both
drug
carriers
therapeutic
agents.
Derived
primarily
from
carbon,
silica,
metals,
metal
oxides,
they
offer
superior
drug-loading
capacity,
heightened
quantum
yield,
participation
advanced
photothermal
photodynamic
therapies.
This
review
provides
brief
overview
pathophysiology
pivotal
role
therapy,
delivery.
Additionally,
it
discusses
numerous
based
recent
literature.
Graphical
abstract
