Critical Reviews in Food Science and Nutrition,
Год журнала:
2022,
Номер
63(33), С. 11925 - 11941
Опубликована: Июль 11, 2022
The
pathophysiology
of
diabetes
has
been
studied
extensively
in
various
countries,
but
effective
prevention
and
treatment
methods
are
still
insufficient.
In
recent
years,
epigenetics
received
increasing
attention
from
researchers
exploring
the
etiology
diabetes.
DNA
methylation,
histone
modifications,
non-coding
RNAs
play
critical
roles
occurrence,
maintenance,
progression
its
complications.
Therefore,
preventing
or
reversing
epigenetic
alterations
that
occur
during
development
may
reduce
individual
societal
burden
disease.
Dietary
flavonoids
serve
as
natural
modulators
for
discovery
biomarkers
alternative
therapies.
However,
there
is
limited
knowledge
about
potential
beneficial
effects
on
this
review,
multidimensional
different
flavonoid
subtypes
were
summarized.
Furthermore,
it
was
discussed
parental
diets
might
incidence
offspring,
which
represent
a
promising
opportunity
to
prevent
future.
Future
work
will
depend
anti-diabetic
with
regulation
mechanisms
clinical
trials.Highlights•
"Epigenetic
therapy"
could
diabetic
patients•
diet"
ameliorates
diabetes•
Targeting
regulations
by
dietary
prevention•
via
transgenerational
inheritance.
Food & Function,
Год журнала:
2022,
Номер
13(19), С. 9734 - 9753
Опубликована: Янв. 1, 2022
Natural
polyphenols
from
different
plants
(including
vegetables,
fruits,
cocoa
beans,
teas
and
herbs)
can
be
used
to
reduce
the
symptoms
of
metabolic
syndrome
(MS).
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(11), С. 6110 - 6110
Опубликована: Июнь 6, 2021
Metabolic
syndrome
(MetS)
is
a
chronic
disease,
including
abdominal
obesity,
dyslipidemia,
hyperglycemia,
and
hypertension.
It
should
be
noted
that
the
occurrence
of
MetS
closely
related
to
oxidative
stress-induced
mitochondrial
dysfunction,
ectopic
fat
accumulation,
impairment
antioxidant
system,
which
in
turn
further
aggravates
intracellular
imbalance
inflammatory
response.
As
enriched
anti-inflammatory
components
plants,
natural
polyphenols
exhibit
beneficial
effects,
improving
liver
accumulation
reducing
blood
pressure.
Hence,
they
are
expected
useful
prevention
management
MetS.
At
present,
epidemiological
studies
indicate
negative
correlation
between
polyphenol
intake
incidence.
In
this
review,
we
summarized
discussed
most
promising
(including
flavonoid
non-flavonoid
drugs)
precaution
treatment
MetS,
their
properties,
as
well
regulatory
functions
involved
glycolipid
homeostasis.
International Journal of Molecular Sciences,
Год журнала:
2020,
Номер
22(1), С. 218 - 218
Опубликована: Дек. 28, 2020
Given
the
growing
number
of
type
2
diabetic
individuals
and
substantial
social
financial
costs
associated
with
diabetes
management,
every
effort
should
be
made
to
improve
its
prevention
treatment
methods.
There
is
an
ongoing
search
for
natural
dietary
compounds
that
could
used
this
purpose.
This
narrative
review
focuses
on
therapeutic
potential
isoflavones
in
treatment.
summarizes
(i)
molecular
mechanisms
action
are
critical
their
anti-diabetic
properties;
(ii)
preclinical
(in
vitro
vivo)
studies
evaluating
influence
function
key
organs
involved
pathogenesis
diabetes;
(iii)
epidemiological
clinical
trials
assessed
effectiveness
humans.
Apart
from
discussing
effects
“classically”
(pancreas,
liver,
muscles,
adipose
tissue),
impact
these
other
contribute
glucose
homeostasis
(gastrointestinal
tract,
kidneys,
brain)
also
reviewed.
Molecules,
Год журнала:
2021,
Номер
26(19), С. 5863 - 5863
Опубликована: Сен. 27, 2021
Isoflavones
are
polyphenols
primarily
contained
in
soybean.
As
phytoestrogens,
isoflavones
exert
beneficial
effects
on
various
chronic
diseases.
Metabolic
syndrome
increases
the
risk
of
death
due
to
arteriosclerosis
individuals
with
pathological
conditions,
including
obesity,
hypertension,
hyperglycemia,
and
dyslipidemia.
Although
health
benefits
soybean-derived
widely
known,
their
pathogenesis
metabolic
incompletely
understood.
This
review
aims
describe
association
between
isoflavone
intake
development.
We
reviewed
studies
soy
isoflavones,
particularly
daidzein
genistein,
syndrome,
using
PubMed,
ScienceDirect,
Web
Science.
characteristics
those
contributing
multiple
conditions.
Furthermore,
we
summarize
genistein
reported
human
epidemiological
experiments
vitro
vivo
models.
In
particular,
emphasize
role
syndrome-induced
cardiovascular
conclusion,
this
focuses
potential
prevent
by
influencing
onset
dyslipidemia,
discusses
anti-inflammatory
isoflavones.
Medicinal Research Reviews,
Год журнала:
2022,
Номер
42(3), С. 1343 - 1371
Опубликована: Янв. 4, 2022
Abstract
A
recent
International
Diabetes
Federation
report
suggests
that
more
than
463
million
people
between
20
and
79
years
have
diabetes.
Of
the
women
affected
by
hyperglycemia
during
pregnancy,
84%
gestational
In
addition,
1.1
children
or
adolescents
are
type
1
Factors
contributing
to
increase
in
diabetes
prevalence
complex
include
contributions
from
genetic,
environmental,
epigenetic
factors.
However,
molecular
regulatory
mechanisms
influencing
progression
of
an
individual
towards
increased
susceptibility
metabolic
diseases
such
as
not
fully
understood.
Recent
studies
suggest
pathogenesis
involves
changes,
resulting
a
persistently
dysregulated
phenotype.
This
review
summarizes
role
mechanisms,
mainly
DNA
methylation
histone
modifications,
development
pancreas,
their
contribution
diabetes,
potential
employment
modulators
treatment.
Aquaculture Nutrition,
Год журнала:
2023,
Номер
2023, С. 1 - 16
Опубликована: Март 31, 2023
A
56-day
feeding
trial
was
conducted
to
investigate
the
effects
of
genistein
on
growth,
lipid
metabolism,
antioxidant
capacity,
and
immunity
common
carp
fed
with
high-carbohydrate
or
high-fat
diets.
Five
diets
were
used
feed
fish:
control
diet
(5%
fat;
CO),
(11%
HF),
(45%
carbohydrate;
HC),
HF
HC
500
mg/kg
(FG
CG).
Results
showed
that
final
body
weight
(FW)
specific
growth
rate
(SGR)
significantly
reduced,
but
supplementation
resulted
in
higher
values
FW
SGR
than
group.
Both
high
carbohydrate
fat
belong
high-energy
diets,
which
may
promote
deposition.
Genistein
obviously
decreased
liver
triglyceride
(TG)
content
alleviated
hepatic
vacuolation
groups.
The
expression
metabolism
genes
(cpt-1
atgl)
markedly
FG
group
synthesis-related
(fas,
acc,
pparγ)
elevated
recovered
level
reduced
after
treatments.
With
respect
fatty
acid
transporter
genes,
fatp
increased
group,
cd36
CG
Furthermore,
immune
indexes,
such
as
total
capacity
(T-AOC),
glutathione
peroxidase
(GSH-PX),
superoxide
dismutase
(SOD),
phosphatase
(ACP),
lysozyme
(LZM)
activities,
decreased,
while
malonate
aldehyde
(MDA)
content,
activities
alanine
aminotransferase
(ALT),
aspartate
(AST)
enhanced
could
be
ameliorated
by
treatment
genistein.
Moreover,
transcript
levels
antioxidant-related
(cat,
gr,
nrf2)
anti-inflammatory
factors
(tgf-β
il-10)
lyz
head
kidney
tissue
promoted,
although
proinflammatory
(tnf-α
il-6)
declined
confirmed
immune-enhancing
Therefore,
ameliorate
negative
immunity.
Genes,
Год журнала:
2023,
Номер
14(11), С. 2070 - 2070
Опубликована: Ноя. 13, 2023
Obesity
is
a
condition
that
characterized
by
the
presence
of
excessive
adipose
tissue
in
body.
has
become
one
main
health
concerns
worldwide
since
it
can
lead
to
other
chronic
ailments,
such
as
type
2
diabetes
or
fatty
liver
disease,
and
could
be
an
aggravating
factor
infections.
MicroRNAs
(miRNAs)
are
small,
non-coding
RNA
molecules
regulate
gene
expression
play
important
role
controlling
crucial
biological
processes
involved
onset
obesity,
lipogenesis,
adipogenesis,
lipid
metabolism,
regulation
cytokines
chemokines.
Moreover,
chemical
compounds
present
food
packaging
alter
miRNA
aforementioned
mechanisms
related
progression.
Furthermore,
therapies,
bariatric
surgery
aerobic
exercise
training,
also
influence
profile
miRNAs
obesity.
Therefore,
review
provides
insight
into
current
research
on
obesity
obesity-derived
intending
develop
novel
therapies
effectively
manage
these
disorders.
Frontiers in Nutrition,
Год журнала:
2022,
Номер
9
Опубликована: Сен. 15, 2022
Mulberry
leaf
is
an
important
medicinal
food
plant,
which
rich
in
polyphenol
compounds.
polyphenols
(MLP)
possess
significant
lipid-lowering
and
antioxidant
effects,
healthcare
functions.
In
this
study,
the
content
of
mulberry
ethanol
extract
was
measured
using
HPLC.
The
analysis
resulted
identification
14
compounds,
Chlorogenic
acid
Quercitrin
were
highest.
A
high-fat
diet
(HFD)-induced
obese
mouse
model
developed
treated
with
MLP
for
12
weeks
to
explore
their
effect
on
lipid
metabolism
HFD-induced
mice.
results
showed
that
could
inhibit
weight
gain
fat
cell
volume
increase
mice
a
dose-dependent
manner.
Further
revealed
decelerated
fatty
composition
adipose
tissues
mice,
significantly
increased
polyunsaturated-to-saturated
(PUFA/SFA)
ratio.
real-time
quantitative
PCR
(RT-qPCR)
indicated
inhibited
down
regulation
uncoupling
protein
(UCP)
1
(UCP1),
UCP3,
PR
domain
zinc
finger
16
(PRDM16)
caused
by
HFD.
These
beneficial
effects
might
be
attributed
ability
change
tissue
expression
thermogenesis
genes.
Overall,
study
suggested
serve
as
potential
weight-loss
functional
products.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2023,
Номер
64(31), С. 11543 - 11555
Опубликована: Июль 27, 2023
Diabetes
mellitus
(DM)
is
a
chronic
metabolic
disease
caused
by
complex
interaction
of
genetic
and
environmental
factors
characterized
persistent
hyperglycemia.
Long-term
hyperglycemia
can
cause
macrovascular
microvascular
damage,
compromise
the
heart,
brain,
kidney,
peripheral
nerves,
eyes
other
organs,
leading
to
serious
complications.
Genistein,
phytoestrogen
derived
from
soybean,
known
for
its
various
biological
activities
therapeutic
properties.
Recent
studies
found
that
genistein
not
only
has
hypoglycemic
activity
but
also
decrease
insulin
resistance.
In
addition,
particular
in
prevention
treatment
diabetic
complications,
such
as
nephropathy,
cardiovascular
disease,
osteoarthrosis,
encephalopathy
retinopathy.
Therefore,
purpose
this
review
summarize
latest
medical
research
progress
DM
related
complications
highlights
potential
molecular
mechanisms
targets.
Meanwhile,
evidence
provided
development
application
drug
or
functional
food
diabetes
