Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans

Antioxidants, Год журнала: 2021, Номер 10(7), С. 1064 - 1064

Опубликована: Июнь 30, 2021

Soybeans are rich in proteins and lipids have become a staple part of the human diet. Besides their nutritional excellence, they also been shown to contain various functional components, including isoflavones, consequently received increasing attention as food item. Isoflavones structurally similar 17-β-estradiol bind estrogen receptors (ERα ERβ). The estrogenic activity isoflavones ranges from hundredth thousandth that itself. play role regulating effects body, depending on situation. Thus, when is insufficient, perform functions estrogen, excessive, block which binds, thus acting an antagonist. In particular, antagonistic important breast, endometrium, prostate, such suppresses cancer occurrence. Genistein, isoflavone, has cancer-suppressing receptor-positive (ER+) cancers, breast cancer. It function enzymes tyrosine protein kinase, mitogen-activated DNA polymerase II, inhibiting cell proliferation inducing apoptosis. Genistein most biologically active potent isoflavone candidate for prevention. Furthermore, among physiological best known antioxidant activities. S-Equol, metabolite genistein daidzein, strong antioxidative effects; however, ability metabolize daidzein into S-equol varies based racial individual differences. may be effective preventing dementia by phosphorylation Alzheimer's-related tau proteins. reduces allergic responses limiting expression mast IgE receptors, involved responses. addition, prevent treat diseases, cardiovascular metabolic syndromes, osteoporosis, diabetes, brain-related high blood pressure, hyperlipidemia, obesity, inflammation. Further, it positive menstrual irregularity non-menopausal women relieving menopausal symptoms middle-aged women. Recently, soybean consumption steep trend Western countries where intake was previously only 1/20-1/50 Asian countries. this review, I dealt with latest research trends substantial interest biological efficacy humans plants, related mechanisms.

Язык: Английский

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Flavonoids in Skin Senescence Prevention and Treatment

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(13), С. 6814 - 6814

Опубликована: Июнь 25, 2021

Skin aging is associated with the accumulation of senescent cells and related to many pathological changes, including decreased protection against pathogens, increased susceptibility irritation, delayed wound healing, cancer susceptibility. Senescent secrete a specific set pro-inflammatory mediators, referred as senescence-associated secretory phenotype (SASP), which can cause profound changes in tissue structure function. Thus, drugs that selectively eliminate (senolytics) or neutralize SASP (senostatics) represent an attractive therapeutic strategy for age-associated skin deterioration. There growing evidence plant-derived compounds (flavonoids) slow down even prevent aging-associated deterioration appearance function by targeting cellular pathways crucial regulating senescence SASP. This review summarizes senostatic senolytic potential flavonoids context preventing aging.

Язык: Английский

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Oxidative Stress in Association with Metabolic Health and Obesity in Young Adults

Oxidative Medicine and Cellular Longevity, Год журнала: 2021, Номер 2021(1)

Опубликована: Янв. 1, 2021

Introduction . Obesity is one of the most important public health problems in world. Among obese people, there are those who, apart from excessive body weight, do not exhibit other metabolic dysfunctions, have a lower risk developing cardiovascular diseases (CVDs), and show mortality. According to theory, they referred as metabolically healthy (MHO), contrast unhealthy (MUO). Metabolic disturbances occurring with obesity been well established be associated oxidative stress. Aim The purpose this study was analyse association between selected anthropometric biochemical parameters stress MHO, MUO, normal weight young adults. Material Methods Individuals age 18 36 years no history chronic use medicaments, or without obesity, participated study. Complete blood counts, measurements, such total antioxidant capacity (TAC), status (TOS), index (OSI), serum concentration malondialdehyde (MDA), ceruloplasmin, thiol groups lipid hydroperoxides (LPH), lipofuscin (LPS) erythrocytes, activity superoxide dismutase (SOD) were measured. Results 422 patients who met inclusion criteria enrolled participants, 208 people (49.29%) offspring angiographically confirmed coronary artery disease. 16 included group (MHO) 61 (MUO) 345 had weight. Significant differences patients, women men, found. Conclusions We showed significant individuals volunteers medical history.

Язык: Английский

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Therapeutic potentials of genistein: New insights and perspectives

Journal of Food Biochemistry, Год журнала: 2022, Номер 46(9)

Опубликована: Май 17, 2022

Genistein, a polyphenolic isoflavone compound found abundantly in soy or soy-based products, is widely consumed the Asian population. Genistein has poor bioavailability, to overcome this problem many advanced nano-drug delivery carrier systems are designed enhance its water solubility and stability. However, further research required develop more efficient bioavailability improvement strategies. phytoestrogen which been associated with reducing risk of cancer, cardiovascular disorders, diabetes mellitus. This plant-based bioactive possesses numerous biological activities such as anti-oxidant, anti-inflammatory, anti-obesity, anti-cancer, cardioprotective, anti-diabetic treat various disease states. used an active therapeutic agent medications. Moreover, several clinical trials ongoing stage treatment therapies, especially for cancer treatment. article highlights protective benefits genistein different ailments, specifically elaborates on anti-cancer potential regarding types cancers. Practical applications versatile activities, including anti-diabetic, anti-angiogenic. The most studied activity anti-cancer. Currently, number pre-clinical being carried out anti-neoplastic cytotoxic novel agents excellent kinds cancer. enhancement strategies have developed improve genistein. shows significant hypoglycemic effects alone combination other agents. chemotherapeutic prostate, bone, colorectal, glioma, breast, bladder

Язык: Английский

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Potential Benefits of Antioxidant Phytochemicals in Type 2 Diabetes

Molecules, Год журнала: 2023, Номер 28(20), С. 7209 - 7209

Опубликована: Окт. 21, 2023

The clinical relationship between diabetes and inflammation is well established. Evidence clearly indicates that disrupting oxidant-antioxidant equilibrium elevated lipid peroxidation could be a potential mechanism for chronic kidney disease associated with type 2 mellitus (T2DM). Under diabetic conditions, hyperglycemia, especially inflammation, increased reactive oxygen species generation are bidirectionally associated. Inflammation, oxidative stress, tissue damage believed to play role in the development of diabetes. Although exact underlying stress its impact on progression remains uncertain, hyperglycemia-inflammation-oxidative interaction plays significant onset vascular disease, hepatic injury, pancreas and, therefore, holds promise as therapeutic target. strongly use multiple antidiabetic medications fails achieve normal range glycated hemoglobin targets, signifying treatment-resistant Antioxidants polyphenols considered useful adjuvant therapy their anti-inflammatory effect antioxidant activity. We aimed analyze current major points reported preclinical, vivo, studies antioxidants prevention or treatment T2DM. Then, we will share our speculative vision future trials.

Язык: Английский

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Augmented Intrarenal and Urinary Angiotensinogen in Diabetic Nephropathy: The Role of Isoflavones

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1443 - 1443

Опубликована: Фев. 8, 2025

The circulating renin-angiotensin system (RAS) is an endocrine with key functions in maintaining blood pressure, fluid volume, and electrolytes. RAS the kidney (intrarenal RAS) plays a critical role onset progression of diseases. However, mechanism underlying diabetic nephropathy relation to expression secretion angiotensinogen (AGT) kidneys remains unclear. In this review, we present overview intrarenal its nephropathy, as well reviewing evidence for use urinary AGT biomarker nephropathy. We also describe roles isoflavones context considered studies show that RAS-especially AGT-plays diversified nephropathy; instance, increase due oxidative stress suppressed by polyphenols antioxidant capacity, which thought affect Therefore, clarification how may provide insights into new treatments illness.

Язык: Английский

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Anti-diabetic effect of modified ‘Guanximiyou’ pummelo peel pectin on type 2 diabetic mice via gut microbiota

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 242, С. 124865 - 124865

Опубликована: Май 17, 2023

Язык: Английский

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Daidzein from Dietary Supplement to a Drug Candidate: An Evaluation of Potential

ACS Omega, Год журнала: 2023, Номер 8(36), С. 32271 - 32293

Опубликована: Авг. 27, 2023

Daidzein (DDZ) is a well-known nutraceutical supplement belonging to the class of isoflavones. It isolated from various sources such as alfalfa, soybean, and red clover. demonstrates broad array pharmacological/beneficial properties cardiovascular exercise, cholesterol reduction, anticancer, antifibrotic, antidiabetic effects, which make it effective in treating wide range diseases. Its structure operation are same those human estrogens, important preventing osteoporosis, cancer, postmenopausal thus promising candidate for development phytopharmaceutical. Addressing safety, efficacy, physicochemical primary prerequisites. DDZ already ingested every day varying amounts, so there should not be significant safety risk; however, each indication requires different dose determined. Some clinical trials being conducted globally confirm its therapeutic potential. Furthermore, result influence on health, order establish intellectual property, patents utilized. In light vast potential eugenol, this review presents detailed data collection substantiate claim develop category.

Язык: Английский

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Formononetin improves the inflammatory response and bone destruction in knee joint lesions by regulating the NF‐kB and MAPK signaling pathways

Phytotherapy Research, Год журнала: 2023, Номер 37(8), С. 3363 - 3379

Опубликована: Апрель 1, 2023

Formononetin (FMN) is a phytoestrogen that belongs to the isoflavone family. It has antioxidant and anti-inflammatory effects, as well as, many other biological activities. Existing evidence aroused interest in its ability protect against osteoarthritis (OA) promote bone remodeling. To date, research on this topic not been thorough issues remain controversial. Therefore, purpose of our study was explore protective effect FMN knee injury clarify possible molecular mechanisms. We found inhibited osteoclast formation induced by receptor activator NF-κB ligand (RANKL). Inhibition phosphorylation nuclear translocation p65 signaling pathway plays role effect. Similarly, during inflammatory response primary cartilage cells activated IL-1β, ERK JNK proteins MAPK suppress response. In addition, vivo experiments showed both low- high-dose had clear DMM (destabilization medial meniscus) model, therapeutic stronger. conclusion, these studies provide injury.

Язык: Английский

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Fermented red pepper paste (kochujang) modulates glucose metabolism and gut microbiota in parasympathetic suppression: Network pharmacology and In vivo study

Food Bioscience, Год журнала: 2024, Номер 61, С. 104531 - 104531

Опубликована: Июнь 16, 2024

Язык: Английский

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