Frontiers in Nutrition,
Год журнала:
2022,
Номер
9
Опубликована: Дек. 1, 2022
Metabolic
associated
fatty
liver
disease
(MAFLD)
formerly
known
as
non-alcoholic
(NAFLD)
is
the
most
common
chronic
disease.
Flavonoid
considered
a
promising
candidate
for
metabolic
prevention
although
few
studies
have
explored
relationship
between
flavonoid
intake
and
MAFLD.To
assess
MAFLD
prevalence
in
U.S.
adult
population.The
data
of
this
cross-sectional
study
was
obtained
from
National
Health
Nutrition
Examination
Survey
(NHANES)
Food
Nutrient
Database
Dietary
Studies
(FNDDS)
2017-2018.
subclasses
assessed
by
two
24h
recalls.
diagnosed
according
to
consensus
definitions.
Multivariate
logistic
regression
model
performed
examine
association
with
adjustments
confounders.A
total
4,431
participants
were
included
analysis.
had
weighted
41.93%
not
intake.
A
higher
anthocyanin
isoflavone
intake,
on
other
hand,
lower
MAFLD.
The
protective
effect
significant
among
male,
Non-Hispanic
White,
Asia
participants.
Higher
risk
younger
(age
<
50),
Black,
Asia,
HEI-2015
scores
compared
lowest
quartile
Stratified
analysis
showed
that
varied
racial
groups
(Pinteraction
=
0.02).
positive
correlation
existed
HDL
anthocyanidin
(P
0.03),
whereas
negative
FPG
0.02).MAFLD
adversely
linked
subclasses,
isoflavone.
This
modifiable
lifestyle
provides
potential
opportunity
prevent
These
findings
promote
future
research
into
links
mechanisms
Antioxidants,
Год журнала:
2021,
Номер
10(7), С. 1064 - 1064
Опубликована: Июнь 30, 2021
Soybeans
are
rich
in
proteins
and
lipids
have
become
a
staple
part
of
the
human
diet.
Besides
their
nutritional
excellence,
they
also
been
shown
to
contain
various
functional
components,
including
isoflavones,
consequently
received
increasing
attention
as
food
item.
Isoflavones
structurally
similar
17-β-estradiol
bind
estrogen
receptors
(ERα
ERβ).
The
estrogenic
activity
isoflavones
ranges
from
hundredth
thousandth
that
itself.
play
role
regulating
effects
body,
depending
on
situation.
Thus,
when
is
insufficient,
perform
functions
estrogen,
excessive,
block
which
binds,
thus
acting
an
antagonist.
In
particular,
antagonistic
important
breast,
endometrium,
prostate,
such
suppresses
cancer
occurrence.
Genistein,
isoflavone,
has
cancer-suppressing
receptor-positive
(ER+)
cancers,
breast
cancer.
It
function
enzymes
tyrosine
protein
kinase,
mitogen-activated
DNA
polymerase
II,
inhibiting
cell
proliferation
inducing
apoptosis.
Genistein
most
biologically
active
potent
isoflavone
candidate
for
prevention.
Furthermore,
among
physiological
best
known
antioxidant
activities.
S-Equol,
metabolite
genistein
daidzein,
strong
antioxidative
effects;
however,
ability
metabolize
daidzein
into
S-equol
varies
based
racial
individual
differences.
may
be
effective
preventing
dementia
by
phosphorylation
Alzheimer's-related
tau
proteins.
reduces
allergic
responses
limiting
expression
mast
IgE
receptors,
involved
responses.
addition,
prevent
treat
diseases,
cardiovascular
metabolic
syndromes,
osteoporosis,
diabetes,
brain-related
high
blood
pressure,
hyperlipidemia,
obesity,
inflammation.
Further,
it
positive
menstrual
irregularity
non-menopausal
women
relieving
menopausal
symptoms
middle-aged
women.
Recently,
soybean
consumption
steep
trend
Western
countries
where
intake
was
previously
only
1/20-1/50
Asian
countries.
this
review,
I
dealt
with
latest
research
trends
substantial
interest
biological
efficacy
humans
plants,
related
mechanisms.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
22(13), С. 6814 - 6814
Опубликована: Июнь 25, 2021
Skin
aging
is
associated
with
the
accumulation
of
senescent
cells
and
related
to
many
pathological
changes,
including
decreased
protection
against
pathogens,
increased
susceptibility
irritation,
delayed
wound
healing,
cancer
susceptibility.
Senescent
secrete
a
specific
set
pro-inflammatory
mediators,
referred
as
senescence-associated
secretory
phenotype
(SASP),
which
can
cause
profound
changes
in
tissue
structure
function.
Thus,
drugs
that
selectively
eliminate
(senolytics)
or
neutralize
SASP
(senostatics)
represent
an
attractive
therapeutic
strategy
for
age-associated
skin
deterioration.
There
growing
evidence
plant-derived
compounds
(flavonoids)
slow
down
even
prevent
aging-associated
deterioration
appearance
function
by
targeting
cellular
pathways
crucial
regulating
senescence
SASP.
This
review
summarizes
senostatic
senolytic
potential
flavonoids
context
preventing
aging.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2021,
Номер
2021(1)
Опубликована: Янв. 1, 2021
Introduction
.
Obesity
is
one
of
the
most
important
public
health
problems
in
world.
Among
obese
people,
there
are
those
who,
apart
from
excessive
body
weight,
do
not
exhibit
other
metabolic
dysfunctions,
have
a
lower
risk
developing
cardiovascular
diseases
(CVDs),
and
show
mortality.
According
to
theory,
they
referred
as
metabolically
healthy
(MHO),
contrast
unhealthy
(MUO).
Metabolic
disturbances
occurring
with
obesity
been
well
established
be
associated
oxidative
stress.
Aim
The
purpose
this
study
was
analyse
association
between
selected
anthropometric
biochemical
parameters
stress
MHO,
MUO,
normal
weight
young
adults.
Material
Methods
Individuals
age
18
36
years
no
history
chronic
use
medicaments,
or
without
obesity,
participated
study.
Complete
blood
counts,
measurements,
such
total
antioxidant
capacity
(TAC),
status
(TOS),
index
(OSI),
serum
concentration
malondialdehyde
(MDA),
ceruloplasmin,
thiol
groups
lipid
hydroperoxides
(LPH),
lipofuscin
(LPS)
erythrocytes,
activity
superoxide
dismutase
(SOD)
were
measured.
Results
422
patients
who
met
inclusion
criteria
enrolled
participants,
208
people
(49.29%)
offspring
angiographically
confirmed
coronary
artery
disease.
16
included
group
(MHO)
61
(MUO)
345
had
weight.
Significant
differences
patients,
women
men,
found.
Conclusions
We
showed
significant
individuals
volunteers
medical
history.
Journal of Food Biochemistry,
Год журнала:
2022,
Номер
46(9)
Опубликована: Май 17, 2022
Genistein,
a
polyphenolic
isoflavone
compound
found
abundantly
in
soy
or
soy-based
products,
is
widely
consumed
the
Asian
population.
Genistein
has
poor
bioavailability,
to
overcome
this
problem
many
advanced
nano-drug
delivery
carrier
systems
are
designed
enhance
its
water
solubility
and
stability.
However,
further
research
required
develop
more
efficient
bioavailability
improvement
strategies.
phytoestrogen
which
been
associated
with
reducing
risk
of
cancer,
cardiovascular
disorders,
diabetes
mellitus.
This
plant-based
bioactive
possesses
numerous
biological
activities
such
as
anti-oxidant,
anti-inflammatory,
anti-obesity,
anti-cancer,
cardioprotective,
anti-diabetic
treat
various
disease
states.
used
an
active
therapeutic
agent
medications.
Moreover,
several
clinical
trials
ongoing
stage
treatment
therapies,
especially
for
cancer
treatment.
article
highlights
protective
benefits
genistein
different
ailments,
specifically
elaborates
on
anti-cancer
potential
regarding
types
cancers.
Practical
applications
versatile
activities,
including
anti-diabetic,
anti-angiogenic.
The
most
studied
activity
anti-cancer.
Currently,
number
pre-clinical
being
carried
out
anti-neoplastic
cytotoxic
novel
agents
excellent
kinds
cancer.
enhancement
strategies
have
developed
improve
genistein.
shows
significant
hypoglycemic
effects
alone
combination
other
agents.
chemotherapeutic
prostate,
bone,
colorectal,
glioma,
breast,
bladder
Molecules,
Год журнала:
2023,
Номер
28(20), С. 7209 - 7209
Опубликована: Окт. 21, 2023
The
clinical
relationship
between
diabetes
and
inflammation
is
well
established.
Evidence
clearly
indicates
that
disrupting
oxidant-antioxidant
equilibrium
elevated
lipid
peroxidation
could
be
a
potential
mechanism
for
chronic
kidney
disease
associated
with
type
2
mellitus
(T2DM).
Under
diabetic
conditions,
hyperglycemia,
especially
inflammation,
increased
reactive
oxygen
species
generation
are
bidirectionally
associated.
Inflammation,
oxidative
stress,
tissue
damage
believed
to
play
role
in
the
development
of
diabetes.
Although
exact
underlying
stress
its
impact
on
progression
remains
uncertain,
hyperglycemia-inflammation-oxidative
interaction
plays
significant
onset
vascular
disease,
hepatic
injury,
pancreas
and,
therefore,
holds
promise
as
therapeutic
target.
strongly
use
multiple
antidiabetic
medications
fails
achieve
normal
range
glycated
hemoglobin
targets,
signifying
treatment-resistant
Antioxidants
polyphenols
considered
useful
adjuvant
therapy
their
anti-inflammatory
effect
antioxidant
activity.
We
aimed
analyze
current
major
points
reported
preclinical,
vivo,
studies
antioxidants
prevention
or
treatment
T2DM.
Then,
we
will
share
our
speculative
vision
future
trials.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1443 - 1443
Опубликована: Фев. 8, 2025
The
circulating
renin-angiotensin
system
(RAS)
is
an
endocrine
with
key
functions
in
maintaining
blood
pressure,
fluid
volume,
and
electrolytes.
RAS
the
kidney
(intrarenal
RAS)
plays
a
critical
role
onset
progression
of
diseases.
However,
mechanism
underlying
diabetic
nephropathy
relation
to
expression
secretion
angiotensinogen
(AGT)
kidneys
remains
unclear.
In
this
review,
we
present
overview
intrarenal
its
nephropathy,
as
well
reviewing
evidence
for
use
urinary
AGT
biomarker
nephropathy.
We
also
describe
roles
isoflavones
context
considered
studies
show
that
RAS-especially
AGT-plays
diversified
nephropathy;
instance,
increase
due
oxidative
stress
suppressed
by
polyphenols
antioxidant
capacity,
which
thought
affect
Therefore,
clarification
how
may
provide
insights
into
new
treatments
illness.
ACS Omega,
Год журнала:
2023,
Номер
8(36), С. 32271 - 32293
Опубликована: Авг. 27, 2023
Daidzein
(DDZ)
is
a
well-known
nutraceutical
supplement
belonging
to
the
class
of
isoflavones.
It
isolated
from
various
sources
such
as
alfalfa,
soybean,
and
red
clover.
demonstrates
broad
array
pharmacological/beneficial
properties
cardiovascular
exercise,
cholesterol
reduction,
anticancer,
antifibrotic,
antidiabetic
effects,
which
make
it
effective
in
treating
wide
range
diseases.
Its
structure
operation
are
same
those
human
estrogens,
important
preventing
osteoporosis,
cancer,
postmenopausal
thus
promising
candidate
for
development
phytopharmaceutical.
Addressing
safety,
efficacy,
physicochemical
primary
prerequisites.
DDZ
already
ingested
every
day
varying
amounts,
so
there
should
not
be
significant
safety
risk;
however,
each
indication
requires
different
dose
determined.
Some
clinical
trials
being
conducted
globally
confirm
its
therapeutic
potential.
Furthermore,
result
influence
on
health,
order
establish
intellectual
property,
patents
utilized.
In
light
vast
potential
eugenol,
this
review
presents
detailed
data
collection
substantiate
claim
develop
category.
Phytotherapy Research,
Год журнала:
2023,
Номер
37(8), С. 3363 - 3379
Опубликована: Апрель 1, 2023
Formononetin
(FMN)
is
a
phytoestrogen
that
belongs
to
the
isoflavone
family.
It
has
antioxidant
and
anti-inflammatory
effects,
as
well
as,
many
other
biological
activities.
Existing
evidence
aroused
interest
in
its
ability
protect
against
osteoarthritis
(OA)
promote
bone
remodeling.
To
date,
research
on
this
topic
not
been
thorough
issues
remain
controversial.
Therefore,
purpose
of
our
study
was
explore
protective
effect
FMN
knee
injury
clarify
possible
molecular
mechanisms.
We
found
inhibited
osteoclast
formation
induced
by
receptor
activator
NF-κB
ligand
(RANKL).
Inhibition
phosphorylation
nuclear
translocation
p65
signaling
pathway
plays
role
effect.
Similarly,
during
inflammatory
response
primary
cartilage
cells
activated
IL-1β,
ERK
JNK
proteins
MAPK
suppress
response.
In
addition,
vivo
experiments
showed
both
low-
high-dose
had
clear
DMM
(destabilization
medial
meniscus)
model,
therapeutic
stronger.
conclusion,
these
studies
provide
injury.