Silver Nanoparticles and Their Antibacterial Applications

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(13), С. 7202 - 7202

Опубликована: Июль 4, 2021

Silver nanoparticles (AgNPs) have been imposed as an excellent antimicrobial agent being able to combat bacteria in vitro and vivo causing infections. The antibacterial capacity of AgNPs covers Gram-negative Gram-positive bacteria, including multidrug resistant strains. exhibit multiple simultaneous mechanisms action combination with agents organic compounds or antibiotics it has shown synergistic effect against pathogens such Escherichia coli Staphylococcus aureus. characteristics silver make them suitable for their application medical healthcare products where they may treat infections prevent efficiently. With the urgent need new efficient agents, this review aims establish factors affecting cytotoxic effects nanoparticles, well expose advantages using antibiotic, which will reduce dosage needed secondary associated both.

Язык: Английский

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Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing

Advanced Materials, Год журнала: 2021, Номер 33(39)

Опубликована: Июль 12, 2021

With all the advances in tissue engineering for construction of fully functional skin tissue, complete regeneration chronic wounds is still challenging. Since immune reaction to damage critical regulating both quality and duration wound healing cascade, strategies modulate system are importance. Generally, response an injury, macrophages switch from pro-inflammatory anti-inflammatory phenotype. Therefore, controlling macrophages' polarization has become appealing approach regenerative medicine. Recently, hydrogels-based constructs, incorporated with various cellular molecular signals, have been developed utilized adjust cell functions stages healing. Here, current state knowledge on during first discussed. Recent advanced technologies used design immunomodulatory hydrogels then summarized. Rational providing controlled stimulation via hydrogel chemistry surface modification, as well incorporation molecules, also dicussed. In addition, effects hydrogels' properties immunogenic features process Finally, future directions upcoming research control responses highlighted.

Язык: Английский

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Synthesis, applications, toxicity and toxicity mechanisms of silver nanoparticles: A review

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 253, С. 114636 - 114636

Опубликована: Фев. 15, 2023

Silver nanoparticles (AgNPs) have become one of the most popular objects study for past few decades. The ability to design AgNPs through different synthetic methods according application area and desired features is their advantage in many applications. Green synthesis silver has potential methods. Because strong antibacterial activity, been used a wide range applications, such as food packaging medical products devices. With increasing AgNPs, it becoming necessary better understanding toxicity mechanism toxicity. In review, we first describe AgNPs. field then briefly described. mechanisms are discussed.

Язык: Английский

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Self‐Assembling Peptide‐Based Hydrogels for Wound Tissue Repair

Advanced Science, Год журнала: 2022, Номер 9(10)

Опубликована: Фев. 9, 2022

Wound healing is a long-term, multistage biological process that includes hemostasis, inflammation, proliferation, and tissue remodeling requires intelligent designs to provide comprehensive convenient treatment. The complexity of wounds has led lack adequate wound treatment materials, which must systematically regulate unique microenvironments. Hydrogels have significant advantages in due their ability spatiotemporal control over the process. Self-assembling peptide-based hydrogels are particularly attractive innate biocompatibility biodegradability along with additional including ligand-receptor recognition, stimulus-responsive self-assembly, mimic extracellular matrix. materials self-assemble response physiological environment, resulting functionalized microscopic structures, makes them conducive This review introduces several self-assembling systems various emphasizes recent advances allow for precise during different stages healing. Moreover, development multifunctional can remodel immune microenvironment therapy also been summarized. Overall, this sheds light on future clinical practical applications hydrogels.

Язык: Английский

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Mussel‐ and Barnacle Cement Proteins‐Inspired Dual‐Bionic Bioadhesive with Repeatable Wet‐Tissue Adhesion, Multimodal Self‐Healing, and Antibacterial Capability for Nonpressing Hemostasis and Promoted Wound Healing

Advanced Functional Materials, Год журнала: 2022, Номер 32(25)

Опубликована: Март 18, 2022

Abstract Massive bleeding and wound infection are the major problems often observed during severe trauma, achieving rapid hemostasis in cases of high‐dose arteries viscera remains an acute clinical demand. Herein, a mussel‐ barnacle cement proteins‐inspired dual‐bionic hydrogel is first proposed. Benefiting from abundant phenolic hydroxyl groups, tough dissipative matrix, removal interfacial water, as well dynamic redox balance phenol‐quinone, multinetwork achieves repeatable robust wet‐tissue adhesiveness (151.40 ± 1.50 kPa), fast multimodal self‐healing ability, excellent antibacterial property against both Gram‐positive/negative bacteria. For rabbit/pig models cardiac penetration holes femoral artery injuries, bioadhesive shows better hemostatic efficiency than commercial gauze due to synergistic effect strong sealing capability, red blood cell capturing property, activation barrier membrane. More interestingly, combined with sponge presents accelerated healing great potential for treating deep‐wound hemorrhage battlefield environment. Overall, owing these unique advantages, novel tissue‐adhesive hemostat opens up new avenue applications.

Язык: Английский

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Green nanotechnology-based zinc oxide (ZnO) nanomaterials for biomedical applications: a review

Journal of Physics Materials, Год журнала: 2020, Номер 3(3), С. 034005 - 034005

Опубликована: Март 19, 2020

Abstract The rise of nanotechnology has brought to the world a new potential and broader perspective what humanity can achieve through material manipulation at nanoscale. As consequence, use different nanomaterials revolutionized both industrial biomedical worlds. Metallic metal-oxide nanostructures have shown great due their high surface volume ratio reactivity. Among them, zinc oxide (ZnO) revealed wider applicability, including in nanomedicine, where ZnO leading effective interactions with biological membranes exhibiting antibacterial and/or anticancer behaviors. However, consistent several other nanostructures, synthesis is not devoid drawbacks, such as production harmful toxic byproducts, reagents, employment expensive instruments, lack biocompatibility, all which need be overcome before extensive use. solution, green allowed using environmentally friendly cost-effective methods, are based on living organisms, natural biomolecules waste materials. Once produced, green-synthesized nanoparticles enhancements terms cytocompatibility properties compared traditionally produced counterparts, becoming excellent or agents. These also proven valuable materials combination wound healing processes biosensing elements order trace small amounts biomarkers associated diseases. there synergy between nanomaterials, an exciting flourishment field, presenting wide variety applications for these nanostructures. This review compares contrasts recent approaches examples synthesized structures, demonstrating remarkable powerful agent.

Язык: Английский

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Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Фев. 21, 2024

Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management

Язык: Английский

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Silver nanoparticles: Advanced and promising technology in diabetic wound therapy

Materials Science and Engineering C, Год журнала: 2020, Номер 112, С. 110925 - 110925

Опубликована: Апрель 11, 2020

Язык: Английский

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Functional Hydrogels for Treatment of Chronic Wounds

Gels, Год журнала: 2022, Номер 8(2), С. 127 - 127

Опубликована: Фев. 17, 2022

Chronic wounds severely affect 1-2% of the population in developed countries. It has been reported that nearly 6.5 million people United States suffer from at least one chronic wound their lifetime. The treatment is critical for maintaining physical and mental well-being patients improving quality life. There are a host methods wounds, including debridement, hyperbaric oxygen therapy, ultrasound, electromagnetic therapies, negative pressure skin grafts, hydrogel dressings. Among these, dressings represent promising viable choice because tunable functional properties, such as biodegradability, adhesivity, antimicrobial, anti-inflammatory, pre-angiogenic bioactivities, can accelerate healing wounds. This review summarizes types phases process, key therapeutic approaches. Hydrogel-based reviewed multifunctional properties advantages Examples commercially available also provided to demonstrate effectiveness over other healing.

Язык: Английский

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Skin-inspired gelatin-based flexible bio-electronic hydrogel for wound healing promotion and motion sensing

Biomaterials, Год журнала: 2021, Номер 276, С. 121026 - 121026

Опубликована: Июль 15, 2021

Язык: Английский

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