Nanomaterials,
Год журнала:
2025,
Номер
15(3), С. 202 - 202
Опубликована: Янв. 27, 2025
Silver
nanoparticles
(AgNPs)
have
gained
significant
attention
in
veterinary
medicine
due
to
their
antimicrobial
properties
and
potential
therapeutic
applications.
has
long
been
recognized
for
its
ability
combat
a
wide
range
of
pathogens,
when
engineered
at
the
nanoscale,
silver’s
surface
area
reactivity
are
greatly
enhanced,
making
it
highly
effective
against
bacteria,
viruses,
fungi.
This
narrative
review
aimed
summarize
evidence
on
AgNPs
current
clinical
applications
medicine.
The
action
involves
several
mechanisms,
including,
among
others,
release
silver
ions,
disruption
cell
membranes
envelopes,
induction
oxidative
stress,
inhibition
pathogens’
replication,
DNA
damage.
Their
size,
shape,
charge,
concentration
influence
efficacy
As
result,
use
explored
animals
infection
prevention
treatment
some
areas,
such
as
wound
care,
coating
surgical
implants,
animal
reproduction,
airway
infections.
They
also
shown
promise
preventing
biofilm
formation,
major
challenge
treating
chronic
bacterial
Additionally,
studied
feed
supplement
enhance
health
growth.
Research
suggested
that
could
stimulate
immune
responses
improve
gut
microbiota
livestock,
potentially
reducing
need
antibiotics
husbandry.
Despite
promising
applications,
further
research
is
necessary
fully
understand
safety,
efficacy,
long-term
effects
animals,
humans,
environment.
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Янв. 21, 2021
Abstract
Biofilms
contribute
to
bacterial
infection
and
drug
resistance
are
a
serious
threat
global
human
health.
Antibacterial
nanomaterials
have
attracted
considerable
attention,
but
the
inhibition
of
biofilms
remains
major
challenge.
Herein,
we
propose
nanohole-boosted
electron
transport
(NBET)
antibiofilm
concept.
Unlike
known
antibacterial
mechanisms
(e.g.,
reactive
oxygen
species
production
cell
membrane
damage),
nanoholes
with
atomic
vacancies
serve
as
electronic
donors
receptors,
respectively,
thus
boost
high
capacity
between
biofilms.
Electron
effectively
destroys
critical
components
(proteins,
intercellularly
adhered
polysaccharides
extracellular
DNA)
biofilms,
also
significantly
downregulate
expression
genes
related
biofilm
formation.
The
anti-infection
is
thoroughly
verified
both
in
vitro
(human
cells)
vivo
(rat
ocular
mouse
intestinal
models),
nanohole-enabled
found
be
highly
biocompatible.
Importantly,
compared
typical
antibiotics,
nonresistant
thereby
exhibit
potential
for
use
various
applications.
As
proof-of-principle
demonstration,
these
findings
hold
promise
NBET
treatments
pathogenic
antibiotic
resistance.
Antibiotics,
Год журнала:
2021,
Номер
10(5), С. 473 - 473
Опубликована: Апрель 21, 2021
Wounds
continue
to
be
a
serious
medical
concern
due
their
increasing
incidence
from
injuries,
surgery,
burns
and
chronic
diseases
such
as
diabetes.
Delays
in
the
healing
process
are
influenced
by
infectious
microbes,
especially
when
they
biofilm
form,
which
leads
persistent
infection.
Biofilms
well
known
for
increased
antibiotic
resistance.
Therefore,
development
of
novel
wound
dressing
drug
formulations
materials
with
combined
antibacterial,
antibiofilm
properties
required.
Nanomaterials
(NM)
have
unique
size
very
large
surface
area
that
wide
range
applications.
Several
NMs
antimicrobial
activity
regeneration
features
thus
give
them
promising
applicability
variety
types.
The
idea
NM-based
antibiotics
has
been
around
decade
at
least
there
many
recent
reviews
use
nanomaterials
antimicrobials.
However,
far
less
attention
given
exploring
if
these
actually
improve
outcomes.
In
this
review,
we
present
an
overview
different
types
explored
specifically
infection
control.
Biotechnology Reports,
Год журнала:
2022,
Номер
34, С. e00714 - e00714
Опубликована: Фев. 26, 2022
The
American
Cancer
Society
estimated
around
61,090
new
cases
of
leukemia
were
diagnosed,
and
23,660
people
died
from
this
disease
in
the
United
States
alone
2021.
Due
to
its
burden
on
society,
there
is
an
unmet
need
explore
innovative
approaches
overcome
leukemia.
Among
different
strategies
that
have
been
explored,
nanotechnology
appears
be
a
promising
effective
approach
for
therapeutics.
Specifically,
biogenic
silver
gold
nanoparticles
(NPs)
attracted
significant
attention
their
antineoplastic
activity
toward
cancer
cells
due
unique
physicochemical
properties.
Indeed,
these
nanostructures
emerged
as
useful
anti-leukemic
applications,
either
carriers
enhance
drug
bioavailability
targeted
delivery
specific
organ
or
novel
therapeutic
agent.
This
review
explores
recent
advances
green
synthesized
nanomaterials
potential
use
against
leukemia,
especially
focusing
(Ag)
(Au)
nanostructures.
In
detail,
we
reviewed
various
eco-friendly
methods
bio-synthesized
NPs,
analytical
properties,
toxicity
effects
leukemic
models.
overview
confirms
satisfactory
potency
NPs
desirable
safety
profiles
human
native
cells,
which
opens
door
commercializing
types
nontherapeutic
agents
if
challenges
involve
clinical
validations,
reproducibility,
scalability
could
resolved.
Biomaterials,
Год журнала:
2023,
Номер
295, С. 122029 - 122029
Опубликована: Янв. 28, 2023
Diabetic
wound
healing
has
attracted
widespread
attention
in
biomedical
engineering.
However,
the
harsh
hypoxic
microenvironment
(HME)
comprising
high
glucose
levels,
local
bleeding,
and
bacterial
infection
often
leads
to
formation
of
hyperplastic
scars,
increasing
clinical
demand
for
dressings.
Here,
we
report
a
comprehensive
strategy
using
near-infrared
NIR-assisted
oxygen
delivery
combined
with
bioactive
nature
biopolymers
remodeling
HME.
Black
phosphorus
(BP)
nanosheets
hemoglobin
(Hb)
were
self-assembled
layerwise
onto
electrospun
poly-l-lactide
(PLLA)
nanofibers
charged
quaternized
chitosan
(QCS)
hyaluronic
acid.
BP
converts
NIR
radiation
into
heat
stimulates
Hb
release
situ.
QCS
is
hemostatic
broad-spectrum
antibacterial
material.
Moderate
BP-derived
photothermal
therapy
can
increase
sensitivity
bacteria
QCS.
A
series
composite
dressings
(coded
as
PQBH-n)
different
numbers
layers
fabricated,
vivo
diabetic
potentials
tested.
The
molecular
mechanism
be
partly
attributed
cytokine-cytokine
receptor
interaction.
Notably,
this
based
on
properties
not
only
applicable
fabricating
multifunctional
but
also
great
potential
expanding
engineering
fields.
