The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
Simple
and
atom-economical
hydrosulfonylation
arylsulfonylation
of
alkenes
have
been
developed
using
sulfinic
acid
as
both
the
sulfonyl
group
source
hydrogen
atom
donor
under
light
irradiation.
These
reactions
feature
catalyst-,
oxidant-,
additive-free
conditions,
offering
a
highly
practical
approach
for
synthesis
diversely
functionalized
sulfones.
Preliminary
mechanistic
studies
indicate
that
these
proceed
via
photoactivation
to
generate
radical,
followed
by
radical
chain
process.
Chemical Reviews,
Год журнала:
2021,
Номер
122(2), С. 2017 - 2291
Опубликована: Ноя. 23, 2021
We
present
here
a
review
of
the
photochemical
and
electrochemical
applications
multi-site
proton-coupled
electron
transfer
(MS-PCET)
in
organic
synthesis.
MS-PCETs
are
redox
mechanisms
which
both
an
proton
exchanged
together,
often
concerted
elementary
step.
As
such,
MS-PCET
can
function
as
non-classical
mechanism
for
homolytic
bond
activation,
providing
opportunities
to
generate
synthetically
useful
free
radical
intermediates
directly
from
wide
variety
common
functional
groups.
introduction
practitioner’s
guide
reaction
design,
with
emphasis
on
unique
energetic
selectivity
features
that
characteristic
this
class.
then
chapters
oxidative
N–H,
O–H,
S–H,
C–H
homolysis
methods,
generation
corresponding
neutral
species.
Then,
reductive
PCET
activations
involving
carbonyl,
imine,
other
X═Y
π-systems,
heteroarenes,
where
ketyl,
α-amino,
heteroarene-derived
radicals
be
generated.
Finally,
we
asymmetric
catalysis
materials
device
applications.
Within
each
chapter,
subdivide
by
group
undergoing
homolysis,
thereafter
type
transformation
being
promoted.
Methods
published
prior
end
December
2020
presented.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(6), С. 2313 - 2382
Опубликована: Янв. 1, 2022
Visible-light
photoredox
catalysis
has
been
regarded
as
an
extremely
powerful
tool
in
organic
chemistry,
bringing
the
spotlight
back
to
radical
processes.
The
versatility
of
photocatalyzed
reactions
already
demonstrated
be
effective
providing
alternative
routes
for
cross-coupling
well
multicomponent
reactions.
photocatalyst
allows
generation
high-energy
intermediates
through
light
irradiation
rather
than
using
highly
reactive
reagents
or
harsh
reaction
conditions.
In
a
similar
vein,
electrochemistry
experienced
fruitful
renaissance
generating
without
need
any
catalyst.
Such
milder
approaches
pose
basis
toward
higher
selectivity
and
broader
applicability.
electrochemical
reactions,
species
acts
starter
cascade
events.
This
diverse
reactivity
use
is
usually
not
covered
by
classical
methods.
Owing
availability
cheaper
more
standardized
photo-
reactors,
easily
scalable
flow-setups,
it
surprising
that
these
two
fields
have
become
areas
increased
research
interest.
Keeping
view,
this
review
aimed
at
overview
synthetic
design
MCRs
involving
and/or
activation
crucial
step
with
particular
focus
on
choice
difunctionalized
reagent.
ChemistrySelect,
Год журнала:
2020,
Номер
5(42), С. 13103 - 13134
Опубликована: Ноя. 13, 2020
Abstract
Sodium
sulfinates,
sulfinic
acids,
sulfonyl
chlorides
and
hydrazides
as
readily
available
efficient
sulfonylation
reagents
have
been
extensively
explored
in
recent
years.
Sulfonyl
radical
can
be
generated
from
these
via
different
methods,
then
the
could
react
with
various
substrates
pathways
to
afford
corresponding
products.
In
this
review,
we
will
summarize
progress
reaction
using
sodium
three
terms
of
reagents,
classify
reactions
into
four
types:
1.
Sulfonylation
sulfinates.
2.
acid.
3.
chlorides.
4.
hydrazides.
Advanced Synthesis & Catalysis,
Год журнала:
2020,
Номер
362(21), С. 4579 - 4654
Опубликована: Авг. 3, 2020
Abstract
Oxidative
coupling
methodology
is
widely
applied
for
the
formation
of
carbon‐carbon
and
carbon‐heteroatom
bonds.
This
review
focuses
on
methods
oxidative
sulfonylation
multiple
bonds
involving
sulfonyl
hydrazides,
sulfinic
acids
their
salts
as
reagents.
Under
conditions,
they
generate
radicals,
trapped
by
resulting
in
a
variety
SO
2
‐containing
products:
mainly,
vinyl
alkynyl
sulfones,
hydroxy‐,
keto,
halo‐substituted
sulfonylated
derivatives
carbo‐
heterocycles.
exhaustive
summarizes
321
references
from
1996
to
2020
with
specialization
studies
last
five
years,
divided
into
chapters
according
classes
compounds
being
sulfonylated.
magnified
image
ChemSusChem,
Год журнала:
2021,
Номер
14(22), С. 4878 - 4902
Опубликована: Сен. 3, 2021
Sulfones
play
a
pivotal
role
in
modern
organic
chemistry.
They
are
highly
versatile
building
blocks
and
find
various
applications
as
drugs,
agrochemicals,
or
functional
materials.
Therefore,
sustainable
access
to
this
class
of
molecules
is
great
interest.
Herein,
the
goal
was
provide
summary
on
recent
developments
field
sulfone
synthesis.
Advances
existing
limitations
traditional
approaches
towards
sulfones
were
reviewed
selected
examples.
Furthermore,
novel
emerging
technologies
for
more
synthesis
future
directions
discussed.
Advanced Synthesis & Catalysis,
Год журнала:
2020,
Номер
362(11), С. 2143 - 2149
Опубликована: Янв. 8, 2020
Abstract
A
sustainable
and
cost‐effective
protocol
for
direct
aminomethylation
of
imidazo‐fused
heterocycles
by
decarboxylative
coupling
reaction
N
‐phenylglycines
with
in
the
presence
CsPbBr
3
under
irradiation
visible
light
has
been
developed.
This
is
first
example
‐catalyzed
heterocycles.
The
eminent
advantage
this
work
that,
easily
prepared
can
be
used
at
least
5
times
without
obvious
reduction
its
activity,
exhibiting
high
catalyst
economic
feature.
magnified
image
Organic & Biomolecular Chemistry,
Год журнала:
2021,
Номер
19(14), С. 3087 - 3118
Опубликована: Янв. 1, 2021
This
review
highlights
recent
developments
relating
to
the
preparation
of
β-keto
sulfones
and
thiosulfones.
And,
also
focused
on
widespread
synthetic
applications
for
assembling
many
valuable
carbo-
heterocycles.
Green Chemistry,
Год журнала:
2023,
Номер
25(21), С. 8459 - 8493
Опубликована: Янв. 1, 2023
This
review
comprehensively
summarizes
visible
light-induced
difunctionalization
strategies
for
alkene
and
alkyne
systems
in
metal-free
conditions
with
literature
coverage
up
to
July
2023.
