Photoinduced, additive- and photosensitizer-free multi-component synthesis of naphthoselenazol-2-amines with air in water

Green Chemistry, Год журнала: 2023, Номер 25(20), С. 7983 - 7987

Опубликована: Янв. 1, 2023

An atom- and step-economical, efficient eco-friendly method for constructing naphthoselenazol-2-amines through a visible-light photocatalytic multi-component reaction under aqueous phase conditions is reported.

Язык: Английский

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EtOH-catalyzed electrosynthesis of imidazolidine-fused sulfamidates fromN-sulfonyl ketimines,N-arylglycines and formaldehyde

Green Chemistry, Год журнала: 2023, Номер 25(14), С. 5539 - 5542

Опубликована: Янв. 1, 2023

With formaldehyde as an atom-economical carbonyl synthon, the EtOH-catalyzed electrochemical multicomponent synthesis of various imidazolidine-fused sulfamidates under organic oxidant-free, energy-saving and mild conditions was developed.

Язык: Английский

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Captopril supported on magnetic graphene nitride, a sustainable and green catalyst for one-pot multicomponent synthesis of 2-amino-4H-chromene and 1,2,3,6-tetrahydropyrimidine

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Ноя. 23, 2023

Abstract Captopril (CAP) is a safe, cost-effective, and environmentally organic compound that can be used as an effective organo-catalyst. Functional groups of captopril make it capable to attach solid support acting promoters in transformations. In this work, was attached the surface magnetic graphene nitride by employing linker agent. The synthesized composite efficiently catalyzed two multicomponent reactions including synthesis 1,2,3,6-tetrahydropyrimidine 2-amino-4 H -chromene derivatives. A large library functional targeted products mild reaction conditions. More importantly, catalyst stable magnetically recycled reused for at least five runs without losing catalytic activity.

Язык: Английский

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Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(7), С. 6581 - 6581

Опубликована: Апрель 1, 2023

Multicomponent reactions (MCRs) have emerged as a powerful strategy in synthetic organic chemistry due to their widespread applications drug discovery and development. MCRs are flexible transformations which three or more substrates react form structurally complex products with high atomic efficiency. They being increasingly appreciated highly exploratory evolutionary tool by the medicinal community, opening door sustainable, cost-effective rapid synthesis of biologically active molecules. In recent years, MCR-based strategies found extensive application field discovery, several anticancer drugs been synthesized through MCRs. this review, we present an overview representative literature examples documenting different approaches development new drugs.

Язык: Английский

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Strain-release transformations of bicyclo[1.1.0]butanes and [1.1.1]propellanes

Tetrahedron Chem, Год журнала: 2024, Номер 9, С. 100070 - 100070

Опубликована: Фев. 28, 2024

Bicyclo[1.1.0]butanes (BCBs) and [1.1.1]propellanes (tricyclo[1.1.1.01,3]pentanes, TCPs) are structurally unique compounds with different chemical properties. Strain-release driven reactions have emerged as an atom- step-economic strategy for the organic synthesis. Using this strategy, a variety of functional ring molecules been efficiently synthesized, including various cyclobutane molecules, bicyclo[2.1.1]hexanes, bicyclo[1.1.1]pentanes, others. More specifically, these strain release-driven include aspects nucleophilic addition, radical electrophilic or transition metal catalysis. This review will discuss recent developments in strain-release transformations bicyclo[1.1.0]butanes [1.1.1]propellanes.

Язык: Английский

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Recent advances in photo- and electro-enabled radical silylation

Organic Chemistry Frontiers, Год журнала: 2022, Номер 9(22), С. 6400 - 6415

Опубликована: Янв. 1, 2022

This review aims to highlight the recent advances in area of radical type silylation reactions mediated by photo- and electrocatalysis.

Язык: Английский

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Synthesis of medium-sized benzo[b]azocines and benzo[b]azonines by photoinduced 8-/9-endo sulfonyl-cyclization

Science China Chemistry, Год журнала: 2023, Номер 66(8), С. 2309 - 2316

Опубликована: Июль 24, 2023

Язык: Английский

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The green chemistry paradigm in modern organic synthesis

Russian Chemical Reviews, Год журнала: 2023, Номер 92(12), С. RCR5104 - RCR5104

Опубликована: Дек. 1, 2023

After the appearance of green chemistry concept, which was introduced in vocabulary early 1990s, its main statements have been continuously developed and modified. Currently, there are 10–12 cornerstones that should form basis for an ideal chemical process. This review analyzes accumulated experience achievements towards design products processes reduce or eliminate use generation hazardous substances. The presents views leading Russian scientists specializing various fields this subject, including homogeneous heterogeneous catalysis, fine basic organic synthesis, electrochemistry, polymer chemistry, based on bio-renewable feedstocks energetic compounds materials. A new approach to quantitative evaluation environmental friendliness by authors is described. <br> bibliography includes 1761.

Язык: Английский

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Recent Advances in Multicomponent Electro‐Organic (Electrochemical) Synthesis of Heterocycles

Asian Journal of Organic Chemistry, Год журнала: 2023, Номер 12(8)

Опубликована: Июль 20, 2023

Abstract In terms of pharmaceuticals and biological applications, synthesis complex organic molecules is a significant fast‐developing area. this context, electrosynthesis an alternative way to the traditional methods for chemo‐, regio‐, stereoselective syntheses. Electro‐organic reactions occur at room temperature normal pressure, through transferring electrons. It has been found that mild approach preparing electrophilic substrates, bases, nucleophiles in situ , from highly stable low‐level reagents; which can be further applied make heterocycles more accessible. While several promising exist, multi‐component (MCRs) have drawn much attention both academia industry worldwide, since they are cost‐efficient environmentally friendly. Combining MCRs produced great strategy field research. This review focuses on recent advances electrochemical heterocyclic compounds via reactions, reported between 2015 March 2023.

Язык: Английский

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Enantioselective Multifunctionalization with Rh Carbynoids

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(48), С. 26403 - 26411

Опубликована: Ноя. 22, 2023

Multifunctionalization from the interception of active intermediates is an attractive synthetic strategy for efficient construction complex molecular scaffolds in atom and step economic fashion. However, design reactions involving metal carbynoids that exhibit carbene/carbocation behavior currently limited, developing catalyst-controlled highly enantioselective versions poses significant challenges. In this study, we present first asymmetric trifunctionalization with rhodium carbynoids. This reaction unveils distinctive reactivity carbynoid precursor, enabling it to react simultaneously two nucleophiles one electrophile. process involves formation distinct carbene ylides alcohol/carbamate trapping ylide imine, resulting three new bonds. Furthermore, allows divergent synthesis a wide array β-amino esters high yields exceptional enantioselectivity.

Язык: Английский

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