Recent advances in the transition metal-free synthesis of heterocycles from α,β-unsaturated ketones

Organic Chemistry Frontiers, Год журнала: 2022, Номер 9(19), С. 5306 - 5357

Опубликована: Янв. 1, 2022

The review highlights the transition metal-free methodologies developed for synthesising various heterocyclic compounds by utilising α,β -unsaturated ketones as valuable synthons during period of 2009 to 2020.

Язык: Английский

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Spiro-Heterocycles: Recent Advances in Biological Applications and Synthetic Strategies

Tetrahedron, Год журнала: 2025, Номер unknown, С. 134468 - 134468

Опубликована: Янв. 1, 2025

Язык: Английский

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Dual-acting β-Aminothiochromones: Design, synthesis, and evaluation as antimicrobial and anti-Angiogenic agents

Bioorganic & Medicinal Chemistry Letters, Год журнала: 2025, Номер unknown, С. 130140 - 130140

Опубликована: Фев. 1, 2025

Язык: Английский

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Anti-hyperlipidemic potential of natural product based labdane-pyrroles via inhibition of cholesterol and triglycerides synthesis

Bioorganic Chemistry, Год журнала: 2021, Номер 108, С. 104664 - 104664

Опубликована: Янв. 27, 2021

Язык: Английский

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DBU-Catalyzed Diastereo/Regioselective Access to Highly Substituted Spiro-oxetane Oxindoles via Ring Annulation of Isatins and Allenoates

The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(13), С. 8882 - 8888

Опубликована: Июнь 26, 2023

A facile and efficient method for the diastereo/regioselective synthesis of highly functionalized spiro-oxetane oxindoles has been described. The 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)-catalyzed reaction proceeds via spiro-annulation isatins allenoates. is compatible with a wide range containing electron-donating groups (EDGs) electron-withdrawing (EWGs) various allenoates affording corresponding products in acceptable yields. It noteworthy that this first protocol constructing structurally diverse motifs pharmaceutical relevance.

Язык: Английский

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Synthesis of aziridines by electrochemical oxidative annulation of chalcones with primary amines

Tetrahedron Letters, Год журнала: 2021, Номер 87, С. 153413 - 153413

Опубликована: Окт. 18, 2021

Язык: Английский

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I₂/TBHP Reagent System: A Modern Paradigm for Organic Transformations**

European Journal of Organic Chemistry, Год журнала: 2022, Номер 2022(30)

Опубликована: Июнь 29, 2022

Abstract Molecular iodine in combination with TBHP offers an advanced concept for organic synthesis and catalysis by improving the selectivity sustainability of transformations. It leads to development metal free greener protocols under ambient conditions either as a catalytic duo or reagent system additive. The advent this indispensable tool led formation complex architectures empowering novel reaction pathways through C−H functionalization, cyclization, cycloaddition, rearrangement, sulfonylation/sulfenylation oxidation reactions synthesis.

Язык: Английский

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Annulations involving 1-indanones to access fused- and spiro frameworks

RSC Advances, Год журнала: 2022, Номер 12(51), С. 33365 - 33402

Опубликована: Янв. 1, 2022

This review highlights recent (2016–2022) annulations of 1-indanones for the construction various fused- and spiro carbo- heterocyclic frameworks.

Язык: Английский

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Multicomponent Synthesis of Spiro-dihydropyridine Oxindoles via Cascade Spiro-cyclization of Knoevenagel/Aza-Michael Adducts

The Journal of Organic Chemistry, Год журнала: 2022, Номер 87(21), С. 13556 - 13563

Опубликована: Окт. 4, 2022

An efficient, straightforward, and one-pot synthesis of biologically relevant spiro-dihydropyridine oxindoles was described via readily available isatin, malononitrile, allenoate, amines. The metal/organocatalyst-free, Et3N-mediated reaction proceeds cascade spiro-cyclization in situ generated Knoevenagel/aza-Michael adducts. has great flexibility over electron-rich electron-poor substituents affording desired products good to excellent yields. We have also demonstrated the selected spiro-dihydropyridines for late-stage diversification into new hybrids pharmaceutical relevance.

Язык: Английский

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Base-enabled access to diastereoselective spirofuran oxindoles and γ-functionalized allenoates

Chemical Communications, Год журнала: 2021, Номер 57(14), С. 1746 - 1749

Опубликована: Янв. 1, 2021

Base assisted divergent reactivity of isatins and allenoates has been achieved, which afforded diastereoselective spirofuran oxindoles γ-functionalized allenoates.

Язык: Английский

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