Diastereoselective construction of structurally diverse trifluoromethyl bispiro-[oxindole-pyrrolidine-chromanone]s through [3+2] cycloaddition reactions DOI
Zheng Li, Lu Yu,

You‐Ping Tian

et al.

Tetrahedron, Journal Year: 2021, Volume and Issue: 98, P. 132297 - 132297

Published: June 18, 2021

Language: Английский

Recent advances in the transition metal-free synthesis of heterocycles from α,β-unsaturated ketones DOI

K. T. Ashitha,

Ajay Krishna M. S.,

D Basavaraja

et al.

Organic Chemistry Frontiers, Journal Year: 2022, Volume and Issue: 9(19), P. 5306 - 5357

Published: Jan. 1, 2022

The review highlights the transition metal-free methodologies developed for synthesising various heterocyclic compounds by utilising α,β -unsaturated ketones as valuable synthons during period of 2009 to 2020.

Language: Английский

Citations

22
Spiro-Heterocycles: Recent Advances in Biological Applications and Synthetic Strategies DOI

D Basavaraja,

Sameer Kumar Devarakonda, A. S.

et al.

Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134468 - 134468

Published: Jan. 1, 2025

Language: Английский

Citations

0
Dual-acting β-Aminothiochromones: Design, synthesis, and evaluation as antimicrobial and anti-Angiogenic agents DOI
Mahesh S. Krishna,

K. T. Ashitha,

Meghashyama Prabhakara Bhat

et al.

Bioorganic & Medicinal Chemistry Letters, Journal Year: 2025, Volume and Issue: unknown, P. 130140 - 130140

Published: Feb. 1, 2025

Language: Английский

Citations

0
Anti-hyperlipidemic potential of natural product based labdane-pyrroles via inhibition of cholesterol and triglycerides synthesis DOI

Renjitha Jalaja,

Shyni G. Leela,

Sangeetha Mohan

et al.

Bioorganic Chemistry, Journal Year: 2021, Volume and Issue: 108, P. 104664 - 104664

Published: Jan. 27, 2021

Language: Английский

Citations

23
DBU-Catalyzed Diastereo/Regioselective Access to Highly Substituted Spiro-oxetane Oxindoles via Ring Annulation of Isatins and Allenoates DOI

D Basavaraja,

C. S. Athira,

Siddalingeshwar V. Doddamani

et al.

The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(13), P. 8882 - 8888

Published: June 26, 2023

A facile and efficient method for the diastereo/regioselective synthesis of highly functionalized spiro-oxetane oxindoles has been described. The 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)-catalyzed reaction proceeds via spiro-annulation isatins allenoates. is compatible with a wide range containing electron-donating groups (EDGs) electron-withdrawing (EWGs) various allenoates affording corresponding products in acceptable yields. It noteworthy that this first protocol constructing structurally diverse motifs pharmaceutical relevance.

Language: Английский

Citations

9
Synthesis of aziridines by electrochemical oxidative annulation of chalcones with primary amines DOI
Dongwen Zeng,

Lijun Gu,

Lizhu Zhang

et al.

Tetrahedron Letters, Journal Year: 2021, Volume and Issue: 87, P. 153413 - 153413

Published: Oct. 18, 2021

Language: Английский

Citations

17
I2/TBHP Reagent System: A Modern Paradigm for Organic Transformations** DOI
Nancy Slathia,

Annah Gupta,

Kamal K. Kapoor

et al.

European Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 2022(30)

Published: June 29, 2022

Abstract Molecular iodine in combination with TBHP offers an advanced concept for organic synthesis and catalysis by improving the selectivity sustainability of transformations. It leads to development metal free greener protocols under ambient conditions either as a catalytic duo or reagent system additive. The advent this indispensable tool led formation complex architectures empowering novel reaction pathways through C−H functionalization, cyclization, cycloaddition, rearrangement, sulfonylation/sulfenylation oxidation reactions synthesis.

Language: Английский

Citations

10
Annulations involving 1-indanones to access fused- and spiro frameworks DOI Creative Commons
Suven Das, Arpita Dutta

RSC Advances, Journal Year: 2022, Volume and Issue: 12(51), P. 33365 - 33402

Published: Jan. 1, 2022

This review highlights recent (2016–2022) annulations of 1-indanones for the construction various fused- and spiro carbo- heterocyclic frameworks.

Language: Английский

Citations

10
Multicomponent Synthesis of Spiro-dihydropyridine Oxindoles via Cascade Spiro-cyclization of Knoevenagel/Aza-Michael Adducts DOI

D Basavaraja,

C. S. Athira,

Siddalingeshwar V. D

et al.

The Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 87(21), P. 13556 - 13563

Published: Oct. 4, 2022

An efficient, straightforward, and one-pot synthesis of biologically relevant spiro-dihydropyridine oxindoles was described via readily available isatin, malononitrile, allenoate, amines. The metal/organocatalyst-free, Et3N-mediated reaction proceeds cascade spiro-cyclization in situ generated Knoevenagel/aza-Michael adducts. has great flexibility over electron-rich electron-poor substituents affording desired products good to excellent yields. We have also demonstrated the selected spiro-dihydropyridines for late-stage diversification into new hybrids pharmaceutical relevance.

Language: Английский

Citations

9
Base-enabled access to diastereoselective spirofuran oxindoles and γ-functionalized allenoates DOI

D Basavaraja,

Ajay Krishna M. S.,

Jagadeesh Krishnan

et al.

Chemical Communications, Journal Year: 2021, Volume and Issue: 57(14), P. 1746 - 1749

Published: Jan. 1, 2021

Base assisted divergent reactivity of isatins and allenoates has been achieved, which afforded diastereoselective spirofuran oxindoles γ-functionalized allenoates.

Language: Английский

Citations

11