Exploring recent advancements and future prospects on coordination self-assembly of the regulated lanthanide-doped luminescent supramolecular hydrogels

Coordination Chemistry Reviews, Год журнала: 2023, Номер 499, С. 215486 - 215486

Опубликована: Окт. 27, 2023

Язык: Английский

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Split and Use: Structural Isomers for Diagnosis and Therapy

Journal of the American Chemical Society, Год журнала: 2020, Номер 142(14), С. 6761 - 6768

Опубликована: Март 15, 2020

Diagnostics and therapeutics are generally separate entities in medicine. Theranostics, agents that provide for both modalities, being developed. However, they often require complex syntheses so as to incorporate within one molecular structure diagnostic therapeutic elements. Moreover, their use is complicated by the disparate dosage requirements diagnosis therapy. Herein, we report closely related porphyrinoid regioisomers produced from same 1,3-dipolar cycloaddition reaction give rise products corresponding ytterbium(III) complexes may be split used biological functions required theranostics. Specifically, cis isomer luminescent suitable NIR imaging, while trans produces singlet oxygen with a good quantum yield thus attractive photodynamic therapy (PDT). Both vitro vivo experiments support complementary of two regioisomers. The present study reveals how ostensibly switch between More broadly, it serves highlight new approach creating paired sets molecules combination effective

Язык: Английский

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Luminescence, chiroptical, magnetic andab initiocrystal-field characterizations of an enantiopure helicoidal Yb(iii) complex

Inorganic Chemistry Frontiers, Год журнала: 2020, Номер 8(4), С. 914 - 926

Опубликована: Окт. 30, 2020

The electronic structure of a chiral Yb(iii)-based complex is fully determined by taking advantage experimental magnetic, luminescence, and chiroptical (NIR-ECD CPL) characterizations in combination withab initiowavefunction calculations.

Язык: Английский

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A Two-Photon Excited Near-Infrared Iridium(III) Complex for Multi-signal Detection and Multimodal Imaging of Hypochlorite

Analytical Chemistry, Год журнала: 2021, Номер 93(10), С. 4628 - 4634

Опубликована: Март 3, 2021

Hypochlorite (ClO–), as a type of reactive oxygen species (ROS), plays crucial role in the process oxidative stress and is closely related to many diseases. Thus, developing method for detecting imaging ClO– with high sensitivity selectivity great significance. However, applications most luminescent probes are limited fact that excitation emission wavelengths them visible light region rather than near-infrared (NIR) region. Hence, an NIR iridium(III) complex (Mul-NIRIr) two-photon designed ClO–. In presence ClO–, intensity lifetime Mul-NIRIr remarkably enhanced. Interestingly, also exhibits excellent electrochemiluminescence (ECL) properties, ECL signal significantly enhanced addition What more, suitable detection analysis by flow cytometry. Therefore, developed detect multiple signals successfully applied exogenous endogenous living cells one-photon, two-photon, phosphorescence image microscopy (PLIM). addition, was used tissues inflammatory mouse models. All above results indicate highly effective systems.

Язык: Английский

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Recent advances of lanthanide nanomaterials in Tumor NIR fluorescence detection and treatment

Materials Today Bio, Год журнала: 2023, Номер 20, С. 100646 - 100646

Опубликована: Май 2, 2023

Lanthanide nanomaterials have garnered significant attention from researchers among the main near-infrared (NIR) fluorescent due to their excellent chemical and fluorescence stability, narrow emission band, adjustable luminescence color, long lifetime. In recent years, with preparation, functional modification, improvement of lanthanide materials, great progress has been made in application biomedical field. This review focuses on latest tumor diagnosis treatment, as well interaction mechanism between biological tissues. We introduce a set efficient strategies for improving properties discuss some representative in-depth research work detail, showcasing superiority early detection ultra-small tumors, phototherapy, real-time guidance surgical resection. However, only realized portion potential applications so far. Therefore, we promising methods further performance future development directions.

Язык: Английский

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Current Development of Lanthanide Complexes for Biomedical Applications

Chemistry - An Asian Journal, Год журнала: 2024, Номер 19(7)

Опубликована: Фев. 13, 2024

Luminescent molecule-based bioimaging system is widely used for precise localization and distinction of cancer/tumor cells. lanthanide (Ln(III)) complexes offer long-lived (sub-millisecond time scale) sharp (FWHM <10 nm) emission, arising from the forbidden 4f-4f electronic transitions. Ln(III) complex-based has emerged as a promising option both in vitro vivo visualizations. In this mini-review, historical development recent significant progress luminescent probes bioapplications are introduced. The studies mainly focused on three points: (i) structural modifications macrocyclic small ligands, (ii) acquirement high resolution luminescence images cells (iii) constructions ratiometric biosensors. Furthermore, our study explained new Cancer GPS (cancer grade probing determining tumor through photophysical property analyses intracellular Eu(III) complex.

Язык: Английский

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Real-time and visual sensing devices based on pH-control assembled lanthanide-barium nano-cluster

Journal of Hazardous Materials, Год журнала: 2021, Номер 413, С. 125291 - 125291

Опубликована: Фев. 5, 2021

Язык: Английский

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Bioorthogonal Lanthanide Molecular Probes for Near‐Infrared Fluorescence and Mass Spectrometry Imaging

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(43)

Опубликована: Авг. 22, 2022

Abstract We report here the development of clickable and highly near‐infrared (NIR) fluorescent lanthanide (Ln) complexes for bioorthogonal labeling biomolecules. These azide‐ or alkyne‐functionalized Ln are hydrophilic fluorogenic, exhibiting a strong increase NIR fluorescence upon conjugation with Metabolic biomolecules azide alkyne, followed by click complexes, enables (NIRF) imaging DNA, RNA, proteins, glycans in cells. Furthermore, multicolor is performed combining click‐labeling immunostaining. In addition, compatible click‐expansion microscopy (click‐ExM), which high‐resolution NIRF cellular glycoproteins. Finally, can be used time‐of‐flight secondary‐ion mass spectrometry (ToF‐SIMS) imaging, thus achieving first example dual‐modal SIMS microscopies.

Язык: Английский

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Singly and Triply Linked Magnetic Porphyrin Lanthanide Arrays

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(19), С. 8693 - 8706

Опубликована: Май 3, 2022

The introduction of paramagnetic metal centers into a conjugated π-system is promising approach toward engineering spintronic materials. Here, we report an investigation two types spin-bearing dysprosium(III) and gadolinium(III) porphyrin dimers: singly

Язык: Английский

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Widened and enhanced near-infrared luminescence of Y2-Sc GaSbO7:Cr3+ phosphors

Journal of Alloys and Compounds, Год журнала: 2023, Номер 956, С. 170377 - 170377

Опубликована: Май 1, 2023

Язык: Английский

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