Abstract
Electrosynthesis
has
recently
attracted
more
and
attention
due
to
its
great
potential
replace
chemical
oxidants
or
reductants
in
molecule‐electrode
electron
transfer.
Sulfonyl
compounds
such
as
sulfonyl
hydrazides,
sulfinic
acids
(and
their
salts),
halides
have
been
discovered
practical
precursors
of
several
radicals.
As
electrochemical
redox
reactions
can
provide
green
efficient
pathways
for
the
activation
compounds,
studies
electrosynthesis
rapidly
increased.
Several
types
radicals
be
generated
from
anodic
oxidation
cathodic
reduction
initiate
fluoroalkylation,
benzenesulfonylation,
cyclization
rearrangement.
In
this
Review,
we
summarize
developments
involving
mainly
last
decade.
Chemical Reviews,
Год журнала:
2021,
Номер
122(2), С. 2487 - 2649
Опубликована: Ноя. 9, 2021
Redox
processes
are
at
the
heart
of
synthetic
methods
that
rely
on
either
electrochemistry
or
photoredox
catalysis,
but
how
do
and
catalysis
compare?
Both
approaches
provide
access
to
high
energy
intermediates
(e.g.,
radicals)
enable
bond
formations
not
constrained
by
rules
ionic
2
electron
(e)
mechanisms.
Instead,
they
1e
mechanisms
capable
bypassing
electronic
steric
limitations
protecting
group
requirements,
thus
enabling
chemists
disconnect
molecules
in
new
different
ways.
However,
while
providing
similar
intermediates,
differ
several
physical
chemistry
principles.
Understanding
those
differences
can
be
key
designing
transformations
forging
disconnections.
This
review
aims
highlight
these
similarities
between
comparing
their
underlying
principles
describing
impact
electrochemical
photochemical
methods.
Green Chemistry,
Год журнала:
2020,
Номер
22(5), С. 1720 - 1725
Опубликована: Янв. 1, 2020
An
eco-friendly
visible-light-induced
decarboxylative
acylation
of
quinoxalin-2(1H)-ones
and
α-oxo
carboxylic
acids
with
air
as
the
oxidant
under
external-photocatalyst-free
conditions
was
established.
Chemical Communications,
Год журнала:
2022,
Номер
58(75), С. 10442 - 10468
Опубликована: Янв. 1, 2022
Fluorine
compounds
are
known
for
their
abundance
in
more
than
20%
of
pharmaceutical
and
agrochemical
products
mainly
due
to
the
enhanced
lipophilicity,
metabolic
stability
pharmacokinetic
properties
organofluorides.
Consequently,
last
decade
has
seen
enormous
growth
incorporation
a
trifluoromethyl
group
into
organic
motifs.
With
significance,
this
review
aims
provide
complete
picture
transition
metal-mediated
construction
C(sp3,
sp2,
sp)-CF3
bonds
via
C-H/X
bond
functionalization
or
addition
processes
both
aliphatic
aromatic
hydrocarbons.
Diversified
reagents
ranging
from
radical
electrophilic
nucleophilic
trifluoromethylating
agents
respective
mechanisms
have
been
further
deliberated
comprehensive
overview.
The
coverage
on
topic
is
expected
make
unique
beneficial
future
applications
enriching
community
towards
improvements
field
trifluoromethylation
reactions,
turn
improving
propensity
development
drugs.
Green Chemistry,
Год журнала:
2020,
Номер
23(1), С. 374 - 378
Опубликована: Окт. 23, 2020
Aryl
radicals
were
generated
for
the
first
time
from
aryl
acyl
peroxides
in
ethyl
acetate
under
ambient
conditions
and
visible-light
illumination
absence
of
any
additive,
metal
catalyst,
or
external
photosensitizer.
Green Chemistry,
Год журнала:
2019,
Номер
21(23), С. 6241 - 6245
Опубликована: Янв. 1, 2019
We
have
developed
a
metal-free
and
catalyst-free
visible-light-promoted
direct
C–H
sulfenylation
of
quinoxalin-2(1H)-ones
with
thiols
for
the
synthesis
diverse
3-sulfenylquinoxalin-2(1H)-ones.
Advanced Synthesis & Catalysis,
Год журнала:
2020,
Номер
362(23), С. 5219 - 5237
Опубликована: Окт. 13, 2020
Abstract
The
importance
of
fluorinated
organic
molecules
in
drugs
and
pharmaceuticals
led
to
the
development
several
synthetic
methods
for
introducing
fluorine
into
bioactive
trifluoromethylation
is
one
key
approaches
same.
Electrochemical
synthesis
has
emerged
as
most
sustainable,
green
strategies
recent
years
new
developments
electroorganic
also
focus
on
electrochemical
compounds.
A
considerable
number
reports
have
appeared
literature
this
review
surveys
all
reactions.
This
highly
sustainable
trifluoromethylating
protocol
will
emerge
further
soon
pave
way
more
energy‐efficient
protocols.
magnified
image
Chemical Communications,
Год журнала:
2019,
Номер
55(97), С. 14685 - 14688
Опубликована: Янв. 1, 2019
The
first
example
of
electrochemically
enabled,
NiCl2-catalyzed
reductive
decarboxylative
coupling
N-hydroxyphthalimide
esters
with
quinoxalinones
was
developed.
